CAS: 25796-04-7; 2-Amino-3-(4-Bromo-1H-Indol-3-yl)Propanoic Acid

上下游产品

2-(4-Bromo-1H-indol-3-ylmethyl)-2-formylamino-malonic acid diethyl ester 3-(Dimethylaminomethyl)indole 1-(4-bromo-1H-indol-3-yl)-N,N-dimethylmethanamine 1-(N-triisopropylsilyl-1H-indol-3-yl)-N,N-dimethylmethanamine

📜4-溴芦竹碱置于盐酸,Sodium Hydroxide,溶剂黄146体系中,用 甲苯 用作溶剂,化学反应 96.0H,反应生成2-氨基-3-(4-溴-1H-吲哚-3-基)丙酸
参考文献:对映体合成的(R)-4-氨基-5-氧代-1,3,4,5-四氢苯并[cd]吲哚,一种含有麦角三环核的高级中间体.
标题:对映体合成的(R)-4-氨基-5-氧代-1,3,4,5-四氢苯并[cd]吲哚,一种含有麦角三环核的高级中间体.
摘要:我们报告了(R)-4-氨基-5-氧代-1,3,4,5-四氢苯并[cd]吲哚的对映体特异性合成的新策略.该化合物是高级中间体,其中包含许多四环麦角生物碱的三环核心.我们的方法涉及从吲哚基锂物种与掩蔽的丝氨酸的偶联初始合成d-4-溴色氨酸.α-氨基位置被n-三苯甲基保护,确保在随后的有机金属环化反应中该位置的对映体完整性.通过用boc基团保护吲哚氮或将α-氨基酮还原为相应的β-氨基醇,可实现三环的稳定.
Doi:10.1021/jo981723S

专利信息

专利号:US-10752927-B2
优先权日:2018-03-01
标 题 :Method for the synthesis of tryptophan analogs in aqueous solvents at reduced temperatures
发明人：BOVILLE CHRISTINA E; ROMNEY DAVID K; ALMHJELL PATRICK J; SIEBEN MICHAELA M
权利人:CALIFORNIA INST OF TECHN
摘要:The present disclosure provides methods for preparing tryptophans and tryptophan derivatives. The methods include: combining i) an indole substrate or azulene substrate, ii) a serine substrate, and iii) an engineered tryptophan synthase β-subunit (TrpB); and maintaining the resulting mixture under conditions sufficient to form the product compound. The engineered TrpB comprises a PLP binding loop mutation, a helix 1 mutation, a strand 7-8 mutation, or a combination thereof. New TrpB variants are also described.

专利号:US-2019271016-A1
优先权日:2018-03-01
标题:Method for the synthesis of tryptophan analogs in aqueous solvents at reduced temperatures

专利号:EP-3759227-A1
优先权日:2018-03-01
标题:Improved method for the synthesis of tryptophan analogs in aqueous solvents at reduced temperatures