CAS: 2576-47-8; 2-Bromoethylamine Hydrobromide

相似化合物

53844-02-3 340187-12-4 683-57-8

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CAS号141-43-5 2-氨基乙醇 | CAS号21841-57-6 aziridine borane | CAS号7726-95-6 溴素 | CAS号574-98-1 N-(2-溴乙基)邻苯二甲酰亚胺 | CAS号151-56-4 氮丙啶 | CAS号35060-08-3 5-二甲基氨基萘-1-(n-(... | CAS号53356-51-7 2-(3,4-二氢异喹啉-2(... | CAS号53844-02-3 N-苄氧羰基-3-溴乙胺 | CAS号497-25-6 2-恶唑烷酮 | CAS号36155-35-8 2-[(4-CHLOROPHE... | CAS号557-66-4 乙胺盐酸盐 | CAS号39684-80-5 2-(B°C-氨基)乙基溴 | CAS号46006-95-5 2,3-二氢-1H-吲哚-1-乙胺 | CAS号14088-81-4 N'-(3-bromophen... | CAS号14088-84-7 N-(2-氨基乙基)-n-(4...

C.I.酸性橙108置于氢溴酸体系中,用 5,5-Dimethyl-1,3-Cyclohexadiene 用作溶剂,化学反应 12.0H,以99%的收率获得2-溴乙胺氢溴酸盐
参考文献:新化合物吗拉贝胺,其制备方法及用途
标题:新化合物吗拉贝胺,其制备方法及用途
摘要:本发明公开一种分子式如式h的新化合物吗拉贝胺(Malabemide),还涉及其制备方法及在药学上的应用.该新化合物以乙醇胺和5‑氯‑2‑吡啶羧酸为起始原料,分别合成相应的中间体2‑溴乙胺氢溴酸盐和5‑氯‑2‑吡啶甲酰氯,再将这两种中间体反应生成5‑氯‑n‑(2‑溴乙基)‑2‑吡啶甲酰胺,最后与吗啉缩合生成吗拉贝胺h.采用本方法制备吗拉贝胺,原料易得,操作简单,产品纯度较好,收率较高,适用于工业化生产.

专利信息

专利号:US-11370736-B2
优先权日:2019-04-01
标 题:Synthesis of fluoro hemiacetals via transition metal-catalyzed fluoro ester and carboxamide hydrogenation
发明人：DUB PAVEL A; BATRICE RAMI J; GORDON JOHN C
权利人:TRIAD NAT SECURITY LLC
摘要:This application is directed to use of transition metal-ligand complexes to hydrogenate fluorinated esters and carboxamides into fluorinated hemiacetals. Methods for synthesis of certain ligands are also provided.

专利号:US-2025011348-A1
优先权日:2023-06-13
标题:Synthesis Process of X-IPM, Stable Crystal Form and Application Thereof
发明人：DUAN JIANXIN; LU ZHAOQIANG; CAI XIAOHONG; FAN JINWEI; QIN WEI; HUANG QUNHUI; ZHANG YANJUN; CHEN WEISU
权利人:ASCENTAWITS PHARMACEUTICALS LTD
摘要:The present application relates to a new method for synthesizing isophosphoramide nitrogen mustard (X-IPM) that is suitable for industrialized production, involves fewer types of solvents, and leads to stable products with high yield. This method is charazterized mainly by the batchwise addition of M (e.g., M is R3N with R being ethyl; i.e., M is triethylamine) and the specific post-reaction treatment, which make it possible for the reaction to fully proceed, lead to products with less impurities, high yield and relatively stable properties, and can lead to stable crystallized substances with specific crystal structures. The present application also relates to stable crystal forms of the isophosphoramide nitrogen mustard (X-IPM) prepared by the aforementioned method, and use of the same as reactants for the synthesis of aziridine structure-containing compounds.

专利号:US-6423871-B1
优先权日:1999-02-26
标题 :Efficient synthesis of secondary amines by selective alkylation of primary amines
发明人：JUNG KYUNG WOON
权利人:UNIV SOUTH FLORIDA
摘要:A method for selective mono-N-alkylation of primary amines to produce secondary amines that are substantially free of overalkylated tertiary amines and quaternary ammonium salts, under mild reaction conditions without the necessity of protecting groups. Compounds of the class of secondary amines are produced by reacting an alkyl halide with an alkyl amine in anhydrous solvent, preferably dimethyl sulfoxide or N,N-dimethylformamide, in the presence of 0.1 to 3 molar equivalents of a cesium base. Optionally, the extent and selectivity of mono-N-alkylation is enhanced by addition to the reaction mixture of a powdered molecular sieve material for removal of water produced by the reaction, and/or tetrabutylammonium iodide to promote halide exchange. The invention permits selective and efficient mono-N-alkylation of a wide variety of substrates at 23° C.; does not cause racemization when used with enantiomerically-pure chiral substrates such as L-α-aminoesters; and is applied to solid phase synthesis whereby either the alkyl amine or alkyl halide is immobilized. The method is additionally used to produce polyamines, such as N-(2-(2-aminoethylthio)ethyl)ethylenediamine in 73% yield.

专利号:WO-0050377-A1
优先权日:1999-02-26
标 题:Efficient synthesis of secondary amines by selective alkylation of primary amines
发明人：JUNG KYUNG WOON
权利人:UNIV SOUTH FLORIDA
摘要:A method for selective mono-N-alkylation of primary amines to produce secondary amines that are substantially free of overalkylated tertiary amines and quaternary ammonium salts, under mild reaction conditions without the necessity of protecting groups. Compounds of the class of secondary amines are produced by reacting an alkyl halide with an alkyl amine in anhydrous solvent, preferably dimethyl sulfoxide or N,N-dimethylformamide, in the presence of 0.1 to 3 molar equivalents of a cesium base. Optionally, the extent and selectivity of mono-N-alkylation is enhanced by addition to the reaction mixture of a powdered molecular sieve material for removal of water produced by the reaction, and/or tetrabutylammonium iodide to promote halide exchange. The invention permits selective and efficient mono-N-alkylation of a wide variety of substrates at 23 °C; does not cause racemization when used with enantiomerically-pure chiral substrates such as L-α-aminoesters; and is applied to solid phase synthesis whereby either the alkyl amine or alkyl halide is immobilized. The method is additionally used to produce polyamines, such as N-(2-(2-aminoethylthio)ethyl)ethylenediamine in 73 % yield.

专利号:US-2025026871-A1
优先权日:2021-04-06
标 题:Cyclic ruthenium benzylidene initiators for enhanced ring expansion metathesis polymerization
发明人：GOLDER MATTHEW; WANG TENG-WEI; JOHNSON JEREMIAH A
权利人:UNIV WASHINGTON; MASSACHUSETTS INSTITUTE OF TECH M I T; MASSACHUSETTS INST TECHNOLOGY
摘要:Cyclic ruthenium benzylidene initiators useful for the controlled synthesis of functionalized cyclic macromolecules via ring-expansion metathesis polymerization.

专利号:US-10266503-B1
优先权日:2016-05-24
标 题 :Sulfoxide ligand metal catalyzed oxidation of olefins
发明人：WHITE M CHRISTINA; AMMANN STEPHEN E; LIU WEI; MA RULIN
权利人:UNIV ILLINOIS
摘要:The enantioselective synthesis of isochroman motifs has been accomplished via Pd(II)-catalyzed allylic C—H oxidation from terminal olefin precursors. Critical to the success of this goal was the development and utilization of a novel chiral aryl sulfoxide-oxazoline (ArSOX) ligand. The allylic C—H oxidation reaction proceeds with the broadest scope and highest levels asymmetric induction reported to date (avg. 92% ee, 13 examples ≥90% ee). Additionally, C(sp 3 )-N fragment coupling reaction between abundant terminal olefins and N-triflyl protected aliphatic and aromatic amines via Pd(II)/sulfoxide (SOX) catalyzed intermolecular allylic C—H amination is disclosed. A range of 52 allylic amines are furnished in good yields (avg. 76%) and excellent regio- and stereoselectivity (avg. >20:1 linear:branched, >20:1 E:Z). For the first time, a variety of singly activated aromatic and aliphatic nitrogen nucleophiles, including ones with stereochemical elements, can be used in fragment coupling stiochiometries for intermolecular C—H amination reactions.