CAS: 214750-75-1; Fmoc-D-Lys(Aloc)-Oh

该化合物是一种受保护的氨酸衍生物,广泛用于固相合成(SPPS),该化合物的特点是N-终点的Fmoc(9-氟烯酰氧碳基)组,确保正向保护兼容性,以及Aloc(丙氧碳基)组保护赖氨链.这种双重保护允许在温和条件下有选择地取消保护,便利受控的浸泡链延长.碱的D配置可增强抗酶降解的稳定性,使其对设计peptiomimics和生物活性peptides具有价值.它与标准SPPS协议的高度纯度和兼容性确保了在复杂的peptide组件中的可靠性.Aloc组可以有选择地使用催化剂来清除,从而在高级peptide工程应用中能够精确的侧链修改.

结构式图片

相似化合物

146982-27-6 147529-99-5 6298-03-9

上下游产品

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Fmoc-L-色氨酸 Fmoc-L-Trp 35737-15-6

合成工艺路线路线简述

    📜二甲基丙二胺,5-溴氨基苯甲酸甲酯,1-碘丁烷,3-溴丙烯,3-甲氧基溴苄,对溴溴苄,间硝基苯酚,2-氨基对苯二甲酸二甲酯,5-硝基-2-甲基苯酚,溴甲苯,碘乙烷,溴乙烷,3-溴苄溴,4-溴甲基苯甲酸甲酯,邻氨基苯甲酸甲酯,3-溴戊烷,Fmoc-L-色氨酸,1-溴戊烷,2-碘乙酰胺,4-氯苄溴,Fmoc-L-苯丙氨酸,Fmoc-L-丙氨酸,3-溴-2-甲基丙烯,N,N-双(3-氨丙基)甲胺,乙二胺,溴丙烷,2-甲基苄溴,1,3-丙二胺,1,6-己二胺,1,5-二氨基戊烷,1-羟基苯并三唑,4-甲基苄溴,溴甲基环丙烷,Fmoc-甘氨酸,4-硝基间甲苯酚,1-溴-2-丁烯,3-甲基苄溴,2-苯氧乙基溴,3-氯苄溴,3-硝基溴苄,对硝基溴化苄,1-溴代异戊烷,氯乙酸叔丁酯,四亚甲基二胺,溴代异丁烷,4-溴-1-丁烯,1-溴-3-甲基-2-丁烯,2-氯苄溴,1,4-双(3-氨基丙基)哌嗪,1,4-苯二甲胺,3-氨基-5-苯基噻吩-2-甲酸甲酯,Di(1H-Imidazol-2-yl)Methanethione,3-氟溴苄,2-氟溴苄,4-氟溴苄,2-溴乙基膦酸二乙酯,Trans-1,4-Diaminocyclohexane,2-溴乙基乙基醚,1,8-二氨基-3,6-二氧杂辛烷,Fmoc-L-异亮氨酸,2-溴乙基甲基醚,1-溴-三氟对二甲苯,2-氰基溴苄,溴甲基环己烷,2-溴溴苄,4-叔丁基苄溴,3-氨基-2-噻吩甲酸甲酯,1-溴-2,2-二甲氧基丙烷,芴甲氧羰酰基-D-正亮氨酸,环氧溴丙烷,2-氨基-4,5-二甲氧基苯甲酸甲酯,2,4-二氟溴苄,1,3-环己烷二胺,3,5-二甲基溴苄,氨乙基硫醚,甲基2-胺-4-氯苯酚酯,3,4-二氟溴苄,Bromomethyl Resin,2-甲氧基-5-硝基苯酚,3-三氟甲基-4-硝基苯酚,3,4,5-三甲氧基氨基苯甲酸甲酯,2,5-二甲基-1,4-苯二胺,9-Fluorenyl-Methoxycarbonyl-Cyclohexyl Alanine,(1R,2R)-1,2-Diaminocyclohexane置于哌啶,Carbonyldiimidazole,Tin-2-Ethylhexanoate Dihydrate,Potassium Tert-Butylate,水,N,N-二异丙基乙胺,三氟乙酸,N,N'-二异丙基碳二亚胺,二溴三苯基膦体系中,用 Dmf (N,N-Dimethyl-Formamide),二氯甲烷,N,N-二甲基乙酰胺,1,2-二氯乙烷 用作溶剂,化学反应生成N-Fmoc-N'-烯丙氧基羰基-D-赖氨酸,N-Fmoc-N'-烯丙氧基羰基-D-赖氨酸,,,,,1-Hydroxy-3,6-Dimethylsulfonamido-8-Sulfonate-Pyrene,,,,,,,6-{[(2S)-Methyl-Pyrrolidin-2-Yl]Methyl}-1-(Tetrahydro-2H-Pyran-4-yl)Indoline,,,,,,3-Amino-N-(5-Tert-Butyl-3-Methanesulfonylamino-2-Methoxy-Phenyl)-4,5-Dimethyl-Benzamide,Decaborane,,,,
    参考文献:Thioquinazolinone Derivatives And Combinatorial Libraries Thereof
    标题:Thioquinazolinone Derivatives And Combinatorial Libraries Thereof
    摘要:本发明涉及一种新的噻喹唑酮衍生物化合物和以下公式的组合化学库:1其中r1到r4,X和y具有此处提供的含义.

    海关参考信息

    专利信息


    专利号:US-2024190924-A1
    优先权日:2021-03-01
    标 题 :Synthesis of Gamma Peptide Nucleic Acid Monomers and Oligomers, and Applications Therefor
    发明人:LY DANITH H; THADKE SHIVAJI A; DHAMI ISHA
    权利人:UNIV CARNEGIE MELLON
    摘要:Provided herein are methods of preparing gamma-peptide nucleic acid monomers, and methods of synthesizing gamma-peptide nucleic acid oligomers.

    专利号:US-8147799-B2
    优先权日:2007-01-11
    标题:Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules
    发明人:MCBRIDE WILLIAM J; GOLDENBERG DAVID M
    权利人:MCBRIDE WILLIAM J; GOLDENBERG DAVID M; IMMUNOMEDICS INC
    摘要:The present application discloses compositions and methods of synthesis and use of F-18 labeled molecules of use, for example, in PET imaging techniques. In particular embodiments, the labeled molecules may be peptides or proteins, although other types of molecules including but not limited to aptamers, oligonucleotides and nucleic acids may be labeled and utilized for such imaging studies. In preferred embodiments, the F-18 label may be conjugated to a targeting molecule by formation of a metal complex and binding of the F-18-metal complex to a chelating moiety, such as DOTA, NOTA, DTPA, TETA or NETA. In other embodiments, the metal may first be conjugated to the chelating group and subsequently the F-18 bound to the metal. In other preferred embodiments, the F-18 labeled moiety may comprise a targetable conjugate that may be used in combination with a bispecific or multispecific antibody to target the F-18 to an antigen expressed on a cell or tissue associated with a disease, medical condition, or pathogen. Exemplary results show that F-18 labeled targetable conjugate peptides are stable in human serum at 37° C. for several hours, sufficient time to perform PET imaging analysis.

    专利号:US-8153100-B2
    优先权日:2007-01-11
    标题 :Methods and compositions for F-18 labeling of proteins, peptides and other molecules
    发明人:MCBRIDE WILLIAM J; D SOUZA CHRISTOPHER A; GOLDENBERG DAVID M
    权利人:MCBRIDE WILLIAM J; D SOUZA CHRISTOPHER A; GOLDENBERG DAVID M; IMMUNOMEDICS INC
    摘要:The present application discloses compositions and methods of synthesis and use of 18 F or 19 F labeled molecules of use in PET or MRI imaging. The labeled molecules may be peptides or proteins, although other types of molecules may be labeled. Preferably, the 18 F or 19 F is conjugated to a targeting molecule by formation of a metal complex and binding of the 18 F- or 19 F-metal complex to a chelating moiety. Alternatively, the metal may first be conjugated to the chelating group and subsequently the 18 F or 19 F bound to the metal. In other embodiments, the 18 F or 19 F labeled moiety may comprise a targetable construct used in combination with a bispecific antibody to target a disease-associated antigen. The 18 F or 19 F labeled targetable construct peptides are stable in serum at 37° C. for a sufficient time to perform PET or MRI imaging.

    专利号:WO-2022187216-A1
    优先权日:2021-03-01
    标题:Synthesis of gamma peptide nucleic acid monomers and oligomers, and applications therefor

    专利号:US-8147800-B2
    优先权日:2007-01-11
    标 题 :Methods and compositions for F-18 labeling of proteins, peptides and other molecules
    发明人:MCBRIDE WILLIAM J; D SOUZA CHRISTOPHER A; GOLDENBERG DAVID M
    权利人:MCBRIDE WILLIAM J; D SOUZA CHRISTOPHER A; GOLDENBERG DAVID M; IMMUNOMEDICS INC
    摘要:The present application discloses compositions and methods of synthesis and use of F-18 labeled molecules of use, for example, in PET imaging techniques. The labeled molecules may be peptides or proteins, although other types of molecules may be labeled by the described methods. Preferably, the F-18 may be conjugated to a targeting molecule by formation of a metal complex and binding of the F-18-metal complex to a chelating moiety. Alternatively, the metal may first be conjugated to the chelating group and subsequently the F-18 bound to the metal. In other embodiments, the F-18 labeled moiety may comprise a targetable construct used in combination with a bispecific or multispecific antibody to target F-18 to a disease-associated antigen, such as a tumor-associated antigen. The F-18 labeled targetable construct peptides are stable in serum at 37° C. for a sufficient time to perform PET imaging analysis.

    专利号:CN-107056894-B
    优先权日:2017-05-26
    标 题:A kind of method for fragment method solid-phase synthesis of ganirelix acetate

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    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: Luckose F, Et Al. Effects Of Amino Acid Derivatives On Physical, Mental, And Physiological Activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.

    合成参考文献


    摘要:Kleemann A., Kutscher B., Reichert D., Bossart M., Pharmaceutical Substances, Thieme [Online], Stuttgart, (2025).
    摘要:Li, Y.; Fang, X.; Wang, Y., Science of Synthesis: DNA-Encoded Libraries, (2024) nan, 53.
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