CAS: 204255-06-1; 5-Azido Oseltamivir

上下游产品

CAS号1149345-89-0 ethyl (3R,4R,5R... | CAS号75-36-5 乙酰氯 | CAS号204255-04-9 N-Desacetyl 5-A... | CAS号1001085-29-5 ethyl (3R,4S,5R... | CAS号1132659-99-4 (3R,4S,5R)-4-ac... | CAS号1163128-59-3 (3R,4R,5S)-ethy... | CAS号108-24-7 乙酸酐 | CAS号196618-13-0 奥司他韦 | CAS号204255-11-8 磷酸奥司他韦

📜D-甘露糖置于吡啶,咪唑,盐酸,4-二甲氨基吡啶,Sodium Periodate,Sodium Azide,硼烷四氢呋喃络合物,草酰氯,硫酸,10% Pd/c,四丁基氟化铵,水,氢气,四氯化钛,Copper(II) Bis(Trifluoromethanesulfonate),Sodium Hydride,二甲基亚砜,三乙胺,三苯基膦体系中,用 四氢呋喃,甲醇,乙醇,二氯甲烷,水,N,N-二甲基甲酰胺 用作溶剂,化学反应 187.92H,反应生成5-叠氮奥塞米韦
参考文献:Org/10.1016/j.Tetlet.2012.08.143
标题:Org/10.1016/j.Tetlet.2012.08.143
摘要:
Doi:Org/10.1016/j.Tetlet.2012.08.143

专利信息

专利号:US-7888337-B2
优先权日:2007-08-31
标 题 :Synthesis of oseltamivir containing phosphonate congeners with anti-influenza activity
发明人：WONG CHI-HUEY; FANG JIM-MIN; SHIE JIUN-JIE; CHENG YIH-SHYUN EDMOND; JAN JIA-TSRONG
权利人:ACADEMIA SINICA
摘要:Novel phosphonate compounds are described. The compounds have activity as neuraminidase inhibitors against wild-type and H274Y mutant of H1N1 and H5N1 viruses. The present disclosure also provides an enantioselective synthetic route to known neuraminidase inhibitors oseltamivir and the anti-flu drug Tamiflu®, as well as novel phosphonate compounds, via D-xylose. Another efficient and flexible synthesis of Tamiflu and the highly potent neuraminidase inhibitor Tamiphosphor was also achieved in 11 steps and >20% overall yields from the readily available fermentation product (1S-cis)-3-bromo-3,5 -cyclohexadiene-1,2-diol. Most of the reaction intermediates were obtained as crystals without tedious purification procedures. The key transformations include an initial regio- and stereoselective bromoamidation of a bromoarene cis-dihydrodiol, as well as the final palladium-catalyzed carbonylation and phosphonylation.

专利号:WO-9955664-A1
优先权日:1998-04-24
标 题 :Preparation of carbocyclic compounds
发明人：BECKER MARK W; CHAPMAN HARLAN H; KELLY DAPHNE E; KENT KENNETH M; LEW WILLARD; LOUIE MICHAEL S; MCGEE LAWRENCE R; PRISBE ERNEST J; POSTICH MICHAEL J; ROHLOFF JOHN C; SCHULTZE LISA M; YU RICHARD H; ZHANG LIJUN
权利人:GILEAD SCIENCES INC; BECKER MARK W; CHAPMAN HARLAN H; KELLY DAPHNE E; KENT KENNETH M; LEW WILLARD; LOUIE MICHAEL S; MCGEE LAWRENCE R; PRISBE ERNEST J; POSTICH MICHAEL J; ROHLOFF JOHN C; SCHULTZE LISA M; YU RICHARD H; ZHANG LIJUN
摘要:The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates useful in the synthesis of neuraminidase inhibitors and compositions useful as intermediates that are themselves useful in the synthesis of neuraminidase inhibitors are provided.

专利号:US-8304553-B2
优先权日:2007-12-19
标题:Method of forming oseltamivir and derivatives thereof
发明人：LIU XUEWEI; MA JIMEI
权利人:LIU XUEWEI; MA JIMEI; UNIV NANYANG TECH
摘要:A process is provided for the synthesis of 4,5-diamino cyclohexene carboxylate ester (1): or a pharmaceutically acceptable salt thereof. R 1 -R 3 are a silyl-, an aliphatic, alicyclic, aromatic, arylaliphatic, or an arylalicyclic group. R 4 , R 11 and R 12 are H, a silyl-group, an aliphatic, alicyclic, aromatic, arylaliphatic, or an arylalicyclic group. 3,4-Dihydropyran compound (9): with R 5 and R 6 being suitable protecting groups, is reacted to form aldehyde (4): which is oxidized and converted to N-substituted carbamate (3): with R 7 being a suitable protecting group. (3) is, via oxazolinidone (13): converted to azido carboxylate ester (2): and then to 4,5-diamino cyclohexene carboxylate ester (1).

专利号:WO-2009029888-A2
优先权日:2007-08-31
标题:Synthesis of oseltamivir containing phosphonate congeners with anti-influenza activity

专利号:US-2010113397-A1
优先权日:2007-08-31
标 题 :Synthesis of oseltamivir containing phosphonate congeners with anti-influenza activity

专利号:AU-2008292859-B2
优先权日:2007-08-31
标题 :Synthesis of oseltamivir containing phosphonate congeners with anti-influenza activity