专利号:US-6525061-B1 优先权日:1999-11-16 标题 :Methods for the solid phase synthesis of 2-amino-4(H)-quinazolinone derivatives 发明人:GOPALSAMY ARIAMALA; YANG HUI Y 权利人:WYETH CORP 摘要:The present invention relates to solid phase synthesis of substituted 2-amino-4(H)-quinazolinone compounds of formula (I):having pharmacological activity, to processes for their preparation, to a combinatorial library and solid phase methods for preparing libraries of the compounds, to utilizing libraries of the compounds for drug discovery, and to pharmaceutical compositions thereof.
专利号:US-8598089-B2 优先权日:2003-12-17 标题 :Methods for synthesis of encoded libraries 发明人:MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A 权利人:MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A; GLAXOSMITHKLINE LLC 摘要:The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.
专利号:US-8410028-B2 优先权日:2003-12-17 标 题:Methods for synthesis of encoded libraries 发明人:MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A 权利人:MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A; GLAXOSMITHKLINE LLC 摘要:The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.
专利号:US-2002049320-A1 优先权日:2000-04-27 标 题:6-amino-2,4-dioxo-3,4-dihydro-1,3,5-triazine derivatives and methods for the solid phase synthesis thereof 发明人:GOPALSAMY ARIAMALA; YANG HUI Y 权利人:AMERICAN CYANAMID CO 摘要:The present invention relates to substituted 6-amino-2,4-dioxo-3,4-dihydro-1,3,5-triazine compounds of formula (I) n n n having pharmacological activity, to solid phase synthesis methods for their preparation, to combinatorial libraries thereof, utilizing libraries of the compounds for drug discovery, and to pharmaceutical compositions thereof.
专利号:US-7247701-B2 优先权日:2002-04-01 标题:Amino amides, peptides and peptidomimetics 发明人:PETASIS NICOS A; YAO XIN 权利人:UNIV SOUTHERN CALIFORNIA 摘要:Synthetic methods and compounds involving amino amides, peptides and peptidomimetics. Amino amide derivatives are prepared via the one-step three-component reaction of a glyoxamide, an amine, and an organoboron derivative. Conversion of the product to another glyoxamide intermediate allows the iterative use of this chemistry for the synthesis of peptides and peptidomimetics.
专利号:US-2007042401-A1 优先权日:2003-12-17 标题 :Methods for synthesis of encoded libraries
参考标题:New And Simple Synthesis Of Acid Azides, Ureas And Carbamates From Carboxylic Acids: Application Of Peptide Coupling Agents Edc And Hbtu 作者:Vommina V. Sureshbabu,H. S. Lalithamba,N. Narendra,H. P. Hemantha 摘要:Conversion Of Carboxylic Acids Into Acid Azides Using Peptide Coupling Agents, Edc And Hbtu Is Described. The Procedure Is Efficient, Practical And Applicable To A Diverse Range Of Carboxylic Acids Including N-Protected Amino Acids. Using The Same Reagents, One-Pot Synthesis Of Ureas, Dipeptidyl Urea Esters And Carbamates From Acids Has Also Been Achieved.
合成参考文献
参考文献:10.1021/jm00010a009 摘要:Hamilton GS, Mewshaw RE, Bryant CM, Feng Y, Endemann G, Madden KS, Janczak JE, Perumattam J, Stanton LW, Yang X. Fluorenylalkanoic and benzoic acids as novel inhibitors of cell adhesion processes in leukocytes. J Med Chem. 1995 May 12;38(10):1650–6. doi: 10.1021/jm00010a009.