CAS: 185116-43-2; Fmoc-4-Abz-Oh

该化合物是一种芳香化合物,其特点是在准位置上有一个苯并二甲酸基碱基,代之以9-氟二氧碳氢化合物(Fmoc),该化合物主要用于peptide合成,作为氨酸的保护组,允许有选择地反应,而不会干扰其他功能组别;Fmoc组因其在基本条件下的稳定性而著称,可以在温和酸条件下去除,使其在合成协议中具有优势;carboxylic酸功能组的存在有助于其在极地溶剂中的溶性,而芳香结构则为欧元的叠叠合相互作用提供了硬性和潜力;此外,4-(Foc-amino)苯甲酸可以参与各种化学反应,包括组合反应,使其在有机合成和药化学中成为有价值的中间体;其特性,例如熔点和溶性,根据化合物的具体条件和纯度而变化.

结构式图片

欧盟法规

C&L通报

上下游产品

CAS号28920-43-6 芴甲氧羰酰氯(Fm°C-Cl) | CAS号150-13-0 对氨基苯甲酸 | CAS号82911-69-1 9-芴甲基-N-琥珀酰亚胺碳酸酯

合成工艺路线路线简述

  • 合成目标产物 Fmoc-4-Aminobenzoic Acid 主要起始原料 9-Fluorenylmethyl Chloroformate And 4-Aminobenzoic Acid
  • (文献来源)合成步骤主要原料 9-Fluorenylmethyl Chloroformate 和 4-Aminobenzoic Acid
📜氯甲酸-9-芴基甲酯,对氨基苯甲酸置于sodium Carbonate,盐酸体系中,用 1,4-二氧六环,水 用作溶剂,以87%的收率获得fmoc-4-氨基苯甲酸
参考文献:一种基于重氮化学的稳定氧化还原调节的一氧化氮自旋标记表面的简便方法.
标题:一种基于重氮化学的稳定氧化还原调节的一氧化氮自旋标记表面的简便方法.
摘要:Tempo衍生物通过重氮化学共价接枝到碳和金表面.硝氧基的酸依赖性氧化还原性质被用来精制电可开关的磁性表面.Esr表征证明了该材料具有可逆和永久磁性.
Doi:10.1039/c3Cc40768C

海关参考信息

专利信息


专利号:US-6525061-B1
优先权日:1999-11-16
标题 :Methods for the solid phase synthesis of 2-amino-4(H)-quinazolinone derivatives
发明人:GOPALSAMY ARIAMALA; YANG HUI Y
权利人:WYETH CORP
摘要:The present invention relates to solid phase synthesis of substituted 2-amino-4(H)-quinazolinone compounds of formula (I):having pharmacological activity, to processes for their preparation, to a combinatorial library and solid phase methods for preparing libraries of the compounds, to utilizing libraries of the compounds for drug discovery, and to pharmaceutical compositions thereof.

专利号:US-8598089-B2
优先权日:2003-12-17
标题 :Methods for synthesis of encoded libraries
发明人:MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A
权利人:MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A; GLAXOSMITHKLINE LLC
摘要:The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.

专利号:US-8410028-B2
优先权日:2003-12-17
标 题:Methods for synthesis of encoded libraries
发明人:MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A
权利人:MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A; GLAXOSMITHKLINE LLC
摘要:The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.

专利号:US-2002049320-A1
优先权日:2000-04-27
标 题:6-amino-2,4-dioxo-3,4-dihydro-1,3,5-triazine derivatives and methods for the solid phase synthesis thereof
发明人:GOPALSAMY ARIAMALA; YANG HUI Y
权利人:AMERICAN CYANAMID CO
摘要:The present invention relates to substituted 6-amino-2,4-dioxo-3,4-dihydro-1,3,5-triazine compounds of formula (I) n n n having pharmacological activity, to solid phase synthesis methods for their preparation, to combinatorial libraries thereof, utilizing libraries of the compounds for drug discovery, and to pharmaceutical compositions thereof.

专利号:US-7247701-B2
优先权日:2002-04-01
标题:Amino amides, peptides and peptidomimetics
发明人:PETASIS NICOS A; YAO XIN
权利人:UNIV SOUTHERN CALIFORNIA
摘要:Synthetic methods and compounds involving amino amides, peptides and peptidomimetics. Amino amide derivatives are prepared via the one-step three-component reaction of a glyoxamide, an amine, and an organoboron derivative. Conversion of the product to another glyoxamide intermediate allows the iterative use of this chemistry for the synthesis of peptides and peptidomimetics.

专利号:US-2007042401-A1
优先权日:2003-12-17
标题 :Methods for synthesis of encoded libraries

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献

参考标题:New And Simple Synthesis Of Acid Azides, Ureas And Carbamates From Carboxylic Acids: Application Of Peptide Coupling Agents Edc And Hbtu
作者:Vommina V. Sureshbabu,H. S. Lalithamba,N. Narendra,H. P. Hemantha
摘要:Conversion Of Carboxylic Acids Into Acid Azides Using Peptide Coupling Agents, Edc And Hbtu Is Described. The Procedure Is Efficient, Practical And Applicable To A Diverse Range Of Carboxylic Acids Including N-Protected Amino Acids. Using The Same Reagents, One-Pot Synthesis Of Ureas, Dipeptidyl Urea Esters And Carbamates From Acids Has Also Been Achieved.

合成参考文献


参考文献:10.1021/jm00010a009
摘要:Hamilton GS, Mewshaw RE, Bryant CM, Feng Y, Endemann G, Madden KS, Janczak JE, Perumattam J, Stanton LW, Yang X. Fluorenylalkanoic and benzoic acids as novel inhibitors of cell adhesion processes in leukocytes. J Med Chem. 1995 May 12;38(10):1650–6. doi: 10.1021/jm00010a009.
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