CAS: 17397-89-6; (2R,3S)-3-((4E,7E)-Nona-4,7-Dienoyl)Oxirane-2-Carboxamide

上下游产品

(2R,3R,4S)-2,3-epoxy-4-hydroxy-7,10-(E,E)-dodecadienamide (2R,3R)-3-[(1R,4E,7E)-1-hydroxy-4,7-nonadienyl]-2-oxiranecarboxamide (1R,4S,5S)-4-Ethoxy-4-((3E,6E)-°Cta-3,6-dienyl)-3,6-dioxa-bicyclo[3.1.0]hexan-2-one (S)-5-But-3-enyl-5-ethoxy-5H-furan-2-one

📜(5S)-5-Ethoxy-5-[(E)-4-Iodobut-3-Enyl]Furan-2-One置于sodium Hypochlorite,氨体系中,用 乙醚,N,N-二甲基甲酰胺 用作溶剂,化学反应 3.5H,反应生成浅蓝菌素
参考文献:通过铬碳烯络合物光化学合成具有不饱和侧链的4-烷基-4-烷氧基丁烯内酯:(+)-Cerulenin.
标题:通过铬碳烯络合物光化学合成具有不饱和侧链的4-烷基-4-烷氧基丁烯内酯:(+)-Cerulenin.
摘要:进一步发展了光学活性烯氨基甲酸酯与含不饱和脂族侧链的铬烷氧基卡宾配合物之间的光化学反应.尽管容忍了包括共轭二烯在内的远端烯烃基团,但均烯丙基侧链发生了分子内反应,从而得到了应变的环丁酮.利用炔基卡宾配合物与旋光性氨基甲酸酯的光化学反应和乙烯基溴的双(β-巴豆基)卤化镍烷基化反应为关键步骤合成了(+)-Cerulenin.
Doi:10.1021/jo960664K

专利信息

专利号:US-7306938-B2
优先权日:1999-12-29
标 题:High throughput screen for inhibitors of fatty acid biosynthesis in bacteria
发明人：MURPHY CHRISTOPHER; YOUNGMAN PHILIP
权利人:MILLENNIUM PHARM INC
摘要:Methods for identifying compounds that are inhibitors of bacterial fatty acid biosynthesis are disclosed. Such compounds can be used as lead compounds in methods for preparing antibacterial agents for treating bacterial infections (e.g., in humans, animals, and plants). Inhibitors of bacterial fatty acid synthesis can also be tested for their ability to inhibit synthesis of acylated homoserine lactones. Compounds that inhibit synthesis of acylated homoserine lactones can be used as inhibitors of bacterial virulence. The disclosed methods allow for high throughput screening of libraries of test compounds.

专利号:US-7579167-B2
优先权日:2002-10-08
标题:Polypeptides involved in the biosynthesis of spiramycins, nucleotide sequences encoding these polypeptides and applications thereof
发明人：BLONDELET-ROUAULT MARIE-HELENE; DOMINGUEZ HELENE; DARBON-RONGERE EMMANUELLE; GERBAUD CLAUDE; GONDRAN ANNE; KARRAY FATMA; LACROIX PATRICIA; OESTREICHER-MERMET-BOUVIER NATHALIE; JEAN-LUC PERNODET; TUPHILE KARINE
权利人:AVENTIS PHARMA S; CENTRE NAT RECH SCIENT
摘要:The present invention relates to the isolation and identification of novel genes of the biosynthetic pathway for spiramycins and to novel polypeptides involved in this biosynthesis. The invention also relates to a method for producing these polypeptides. It also relates to the use of these genes for the purpose of increasing the levels of production and the purity of the spiramycin produced. The invention relates in particular to a microorganism which produces spiramycin I but which does not produce spiramycin II and III, and to the use of such a microorganism. The invention also relates to the use of the genes of the biosynthetic pathway for spiramycins for constructing mutants which can lead to the synthesis of novel antibiotics or to derived forms of spiramycins. The invention also relates to the molecules produced through the expression of these genes and to pharmacologically active compositions of a molecule produced through the expression of such genes.

专利号:US-8124794-B2
优先权日:2002-04-17
标题:Method for the asymmetric synthesis of beta-lactone compounds
发明人：SMITH JEFFREY W; AXELROD FUMIKO; KRIDEL STEVEN J; ROMO DANIEL; PUROHIT VIKRAM; MA GIL
权利人:SMITH JEFFREY W; AXELROD FUMIKO; KRIDEL STEVEN J; ROMO DANIEL; PUROHIT VIKRAM; MA GIL; SANFORD BURNHAM MED RES INST
摘要:The present invention features methods of treating a cancer in a subject by administering an effective amount of a beta-lactone to the subject. The invention also features methods of inhibiting angiogenesis in a subject by administering an effective amount of an inhibitor of fatty acid synthase to the subject. These methods can be used to treat a variety of cancers and other diseases and conditions. The invention also features methods of identifying beta-lactones and other compounds that can be used in the methods of the invention for the treatment of tumors, inhibition of angiogenesis, and the treatment of diseases and conditions that involve pathological angiogenesis. The invention also features methods of synthesizing beta-lactones and features novel beta-lactone compounds.

专利号:US-6051383-A
优先权日:1995-06-26
标题:Sequences for production of 2,4-diacetylphloroglucinol and methods
发明人：THOMASHOW LINDA S; BANGERA MAHALAXMI; WELLER DAVID M; COOK R JAMES
权利人:US AGRICULTURE; UNIV WASHINGTON
摘要:DNA sequences which function specifically in the synthesis of 2,4-diacetylphloroglucinol (Phl) are described. The sequences include phl genes which encode phl gene proteins and coding and regulatory sequences for production of Phl as well as sequences containing phl genes, which sequences have the capability of conferring or enhancing Phl biosynthetic capability in bacterial strains. The transformed strains are useful as biocontrol agents against fungal pathogens.

专利号:US-7994222-B2
优先权日:2006-09-05
标 题:Monitoring of the inhibition of fatty acid synthesis by iodo-nitrobenzamide compounds
发明人：OSSOVSKAYA VALERIA S; SHERMAN BARRY M
权利人:BIPAR SCIENCES INC
摘要:The present invention relates to a method of treating a fatty acid synthesis related disease comprising administering to a patient in need thereof an effective amount of a PARP inhibitor or metabolite thereof to inhibit fatty acid synthesis, wherein the fatty acid synthesis related disease is obesity, diabetes, or cardiovascular disease. The present invention also relates to a method of treating a cancer in a subject comprising: (i) identifying a level of fatty acid in a sample from the subject, and (ii) administering an effective amount of a PARP inhibitor or metabolite thereof to inhibit fatty acid synthesis in the subject, wherein the administration is based on the level of fatty acid, thereby treating the cancer in the subject. The present invention further relates to a method of treating Her-2 related cancers by administering to a patient in need thereof an effective amount of a PARP inhibitor or metabolite thereof to inhibit fatty acid synthesis.

专利号:US-5614551-A
优先权日:1994-01-24
标题:Inhibitors of fatty acid synthesis as antimicrobial agents
发明人：DICK JAMES D; KUHAJDA FRANCIS P
权利人:UNIV JOHNS HOPKINS
摘要:Fatty acid synthase (FAS) is overexpressed by certain infectious organisms that are resistant to most currently available antibiotics. Contrarywise, little FAS expression is identified in patient tissues. Inhibition of fatty acid synthesis is thus selectively toxic to invasive cells, while patient cells with low FAS activity are resistant. This invention provides a method of treating septic patients where fatty acid synthesis by invading cells is inhibited with resultant interruption of the disease process.