CAS: 154471-65-5; 1-Methyl-3-(Trifluoromethyl)-1H-Pyrazole

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上下游产品

CAS号59938-06-6 (E)-4-乙氧基-1,1,1... | CAS号60-34-4 甲基肼 | CAS号20154-03-4 3-三氟甲基吡唑 | CAS号74-88-4 碘甲烷 | CAS号497832-99-2 1-甲基-3-三氟甲基-4-溴... | CAS号344591-91-9 (1-甲基-3-三氟甲基-1H... | CAS号128694-63-3 2-甲基-5三氟甲基-2H-吡... | CAS号113100-53-1 1-甲基-3-三氟甲基-1H-... | CAS号81769-69-9 1-methyl-4-(tri... | CAS号70631-94-6 1-methyl-2-(tri... | CAS号497833-05-3 4-Bromo-1-methy...

4-Butoxy-2,2,4-Trichloro-1,1,1-Trifluorobutane,甲基肼置于溶剂黄146体系中,用 水 用作溶剂,化学反应 1.0H,以85%的收率获得1-甲基-3-三氟甲基-1H-吡唑
参考文献:一种吡唑类化合物的制备方法
标题:一种吡唑类化合物的制备方法
摘要:本发明公开了一种吡唑类化合物的制备方法.该方法包括:方法a:溶剂中,将如式(Ii‑a)所示的化合物与如式(III)所示的化合物进行环合反应,制得如式(I)所示的化合物;方法b:溶剂中,将如式(Ii‑b)所示的化合物与如式(III)所示的化合物环合反应,制得如式(I)所示的化合物.本发明的制备方法原料廉价易得,生产成本低,反应条件温和,操作简单,目标化合物收率和纯度高,绿色环保,更适用于工业化生产.

专利信息

专利号:US-2013338369-A1
优先权日:2011-03-07
标 题 :Process for the Synthesis of Aminobiphenylene
发明人：HEINRICH MARKUS; PRATSCH GERALD
权利人:HEINRICH MARKUS; PRATSCH GERALD; BASF SE
摘要:The present invention relates to a process for the synthesis of 2-aminobiphenylene and derivatives thereof by reacting a benzene diazonium salt with an aniline compound under basic reaction conditions.

专利号:US-12336981-B2
优先权日:2010-09-03
标题 :Compounds and compositions for the inhibition of NAMPT
发明人：BAIR KENNETH W; BAUMEISTER TIMM R; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; DRAGOVICH Peter; GOSSELIN FRANCIS; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; ROTH BRUCE; SMITH CHASE C; WANG ZHONGGUO; YUEN PO-WAI; ZHENG XIAOZHANG
权利人:VALO HEALTH INC; GENENTECH INC
摘要:The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:

专利号:CN-107652242-B
优先权日:2017-10-09
标 题 :Synthesis of pyrimidine salicylic acid oxime ester and application of pyrimidine salicylic acid oxime ester as herbicide

专利号:WO-2012120003-A1
优先权日:2011-03-07
标 题 :Process for the synthesis of aminobiphenylene

专利号:EP-2683682-A1
优先权日:2011-03-07
标题 :Process for the synthesis of aminobiphenylene

专利号:US-9925177-B2
优先权日:2015-01-22
标题:4-methylsulfonyl-substituted piperidine urea compounds
发明人：OSLOB JOHAN; AUBELE DANIELLE; KIM JAE; MCDOWELL ROBERT; SONG YONGHONG; SRAN ARVINDER; ZHONG MIN
权利人:MYOKARDIA INC
摘要:The present invention provides novel 4-methylsulphone-substituted piperidine urea compounds that are useful for the treatment of dilated cardiomyopathy (DCM) and conditions associated with left and/or right ventricular systolic dysfunction or systolic reserve. The synthesis and characterization of the compounds is described, as well as methods for treating DCM and other forms of heart disease.