专利号:US-9126995-B2 优先权日:2011-11-08 标题:Method for catalytic asymmetric synthesis of optically active isoxazoline compound and optically active isoxazoline compound 发明人:TOYAMA KEN-ICHI; MORIYAMA YUJI; MATOBA KAZUTAKA; YAOSAKA MANABU; IKEDA EITATSU 权利人:NISSAN CHEMICAL IND LTD 摘要:There is provided a method for catalytic asymmetric synthesis of optically active isoxazoline compound and an optically active isoxazoline compound. A method for catalytic asymmetric synthesis of optically active isoxazoline compound of a formula (6) including reacting an α,β-unsaturated carbonyl compound of a formula (1) and a hydroxylamine in a solvent in the presence of a base by adding a chiral phase transfer catalyst. An optically active isoxazoline compound of a formula (13) that can be synthesized by the method.
专利号:US-9879043-B1 优先权日:2013-06-06 标 题:Synthesis of non-natural cofactor analogs of S-adenosyl-L-methionine using methionine adenosyltransferase 发明人:THORSON JON; HUBER TYLER; ZHANG JIANJUN; Singh Shanteri 权利人:UNIV KENTUCKY RES FOUND 摘要:The present disclosure relates to the synthesis of non-natural analogs of S-adenosyl-L-methionine (SAM) and/or of Se-adenosyl-L-methionine (SeAM) by reacting a methionine analog and adenosine triphosphate (ATP) in the presence of at least one methionine adenosyltransferase (MAT), and to use thereof with downstream SAM and/or SeAM utilizing enzymes. The non-natural analogs of SAM and/or SeAM have the general formula: n nwhere X is S or Se, and R 1 is an alkyl group.
专利号:US-9249165-B2 优先权日:2013-08-30 标题 :Slurry phase direct synthesis of organohalosilanes from cyclone fines 发明人:LEWIS KENRICK MARTIN; ZHU YANJUN; MEREIGH ABELLARD T; RAZZANO JOHN; NEELY JOHN DAVID 权利人:MOMENTIVE PERFORMANCE MAT INC 摘要:The present invention is directed to a process for the synthesis of organohalosilane monomers, comprising the steps of (1) forming a slurry of cyclone fines, ultra fines and/or spent contact mass in a thermally stable solvent and reacting the agitated slurry with an organohalide of the formula R 1 X in the presence of an additive for a time and at a temperature sufficient to produce organohalosilane monomers having the formulae R 1 SiHX 2 , R 1 2 SiHX, R 1 3 SiX, R 1 SiX 3 , and R 1 2 SiX 2 ; wherein R 1 is a saturated or unsaturated aromatic group, a saturated or unsaturated aliphatic group, alkaryl group, or cycloaliphatic hydrocarbyl group, and X is a halogen; and (2) recovering said organohalosilane monomers.
专利号:US-2006079719-A1 优先权日:2002-04-16 标 题 :Aminated compounds bearing at least an allyl and a difluoromethyl and method used for synthesis thereof 发明人:BONNET-DELPON DANIELE; BEGUE JEAN-PIERRE; LEGROS JULIEN; CROUSSE BENOIT; MEYER FRANCK 权利人:BONNET-DELPON DANIELE; BEGUE JEAN-PIERRE; LEGROS JULIEN; CROUSSE BENOIT; MEYER FRANCK 摘要:The invention relates to aminated compounds bearing at least an allyl and a difluoromethyl and a method used for synthesis thereof. Said compounds comprise at least one carbon bearing: an amine function, an allyl or propargyl radical, a difluoromethylene group, and a hydrogen or a hydrocarbon radical, advantageously selected among those which are electron donors or hardly electroattractive (; 0. 1). The invention is useful for synthesis of fluorinated compounds.
专利号:US-6313068-B1 优先权日:1998-08-20 标 题:Synthesis methods, complexes and delivery methods for the safe and convenient storage, transport and application of compounds for inhibiting the ethylene response in plants 发明人:DALY JAMES; KOURELIS BOB 权利人:AGROFRESH INC 摘要:The present invention generally relates to the regulation of plant physiology, in particular to methods for inhibiting the ethylene response in plants or plant products, and has three embodiments. The first embodiment relates to methods of minimizing impurities capable of reversibly binding to plant ethylene receptor sites during the synthesis of cyclopropene and its derivatives such as methylcyclopropene, thereby avoiding the negative effects these impurities have on plants treated with cyclopropene and its derivatives. The second embodiment relates to complexes formed from molecular encapsulation agents such as cyclodextrin, and cyclopropene and its derivatives such as methylcyclopropene, in addition to cyclopentadiene and diazocyclopentadiene and their derivatives, thereby providing a convenient means for storing and transporting these compounds capable of inhibiting the ethylene response in plants, which are reactive gases and highly unstable because of oxidation and other potential reactions. The third embodiment relates to convenient methods of delivering to plants these compounds capable of inhibiting the ethylene response in the plants in order to extend their shelf life.
专利号:US-8309599-B2 优先权日:2006-09-08 标题 :Synthesis of FR901464 and analogs with antitumor activity 发明人:KOIDE KAZUNORI; ALBERT BRIAN J; SIVARAMAKRISHNAN ANANTHAPADMANABHAN 权利人:KOIDE KAZUNORI; ALBERT BRIAN J; SIVARAMAKRISHNAN ANANTHAPADMANABHAN; UNIV PITTSBURGH 摘要:The present invention provides novel analogs of FR901464, as well as an improved methodology for preparing FR901464 and its analogs. These compounds display an anti-cancer activity and are candidates for therapies against a number of disease states associated with dysfunctional RNA splicing.