CAS: 14165-27-6; N1,N1-Dibenzylethane-1,2-Diamine

相似化合物

945218-50-8 84425-29-6 3984-76-7

上下游产品

N,N-dibenzyl-2-chloroethanamine 2-(2-bromoethyl)isoindoline-1,3-dione dibenzylamine N,N-dibenzylamino-acetonitrile4-(1,3-dibenzyl-imidazolidin-2-yl)-phenol -guanidin2-Dibenzylamino-aethyl-guanidin ethyl>benzamide4-(1H-imidazol-1-yl)-N-2-ethylbenzamide N-[2-(N',N'-dibenzylamino)ethyl]-4-amino-5-chloro-2-methoxy-benzamide

📜N,N-Dibenzylaminoacetonitrile置于lithium Aluminium Tetrahydride体系中,用 乙醚 用作溶剂,化学反应 1.0H,反应生成N,N'-二苄基乙二胺
参考文献:Synthesis And Neuroleptic Activity Of Benzamides. Cis-N-(1-Benzyl-2-Methylpyrrolidin-3-yl)-5-Chloro-2-Methoxy-4-(Methylamino)Benzamide And Related Compounds
标题:Synthesis And Neuroleptic Activity Of Benzamides. Cis-N-(1-Benzyl-2-Methylpyrrolidin-3-yl)-5-Chloro-2-Methoxy-4-(Methylamino)Benzamide And Related Compounds
摘要:Three Series Of Benzamides Of N,N-Disubstituted Ethylenediamines (Linear Alkane-1,2-Diamines),1-Substituted 2-(Aminomethyl)Pyrrolidines,And 1-Substituted 3-Aminopyrrolidines (Cyclic Alkane-1,2-Diamines) Were Designed And Synthesized As Potential Neuroleptics. All Target Compounds Were Evaluated For Their Inhibitory Effects On Apomorphine-Induced Stereotyped Behavior In Rats,And A Good Correlation Between Structure And Activity Was Found Throughout The Series. In The Linear Series (Analogues Of Metoclopramide),Introduction Of A Benzyl Group On The Terminal Nitrogen,Rather Than An Ethyl Group,And A Methyl Group On The P-Amino Group Of Metoclopramide Both Enhanced The Activity. The Resulting N-[2-(N-Benzyl-N-Methylamino)Ethyl]-5-Chloro-2-Methoxy-4-(Methylamino) Benzamide(23) Was About 15 Times More Active Than Metoclopramide. In The Cyclic Series,Particularly Among The Benzamides Of 1-Benzyl-3-Aminopyrrolidine,Most Of The Compounds Tested Were More Active Than The Corresponding Linear Benzamides. Cis-N-(1-Benzyl-2-Methylpyrrolidin-3-yl)-5-Chloro-2-Methoxy-4-(Methylamino) Benzamide (Ym-09151-2,55) Was The Most Active Among All Of The Compounds Tested,Being 13 And 408 Times More Potent Than Haloperidol And Metoclopramide,Respectively. Moreover,Compound 55 Exhibited A Fairly High Ratio Of Antistereotypic Activity To Cataleptogenicity Compared With Haloperidol And Metoclopramide. It Is Expected That Compound 55 May Be Used As A Potent Drug With Few Side Effects In The Treatment Of Psychosis.
Doi:10.1021/jm00142A019

专利信息

专利号:WO-9740025-A1
优先权日:1996-04-19
标 题 :Solid phase and combinatorial synthesis of substituted 1,2,3-triazoles and of arrays of substituted 1,2,3-triazoles
发明人：DOERWALD FLORENCIO ZARAGOZA
权利人:NOVO NORDISK AS; DOERWALD FLORENCIO ZARAGOZA
摘要:A solid phase method for the synthesis of a plurality of differently substituted 1,2,3-triazoles with a wide variety of side-chain substituents as compounds of potential therapeutic interest. The 1,2,3-triazoles are prepared by acylation of a substrate-bound primary or secondary amine with a 3-oxoalkanoic acid and reaction of the resulting amide with a primary amine under dehydrating conditions to give an enamine. Treatment of this substrate-bound enamine with a sulfonyl azide in the presence of a base gives the corresponding 1,2,3-triazoles. These may be screened on the substrate or cleaved from the substrate and then screened in solution. The efficient synthesis of a wide variety of 1,2,3-triazoles using automated synthesis technology of the present method makes these compounds attractive candidates for the generation and rapid screening of diverse triazole-based libraries. The method disclosed here provides an easy and fast access to highly diverse heterocyclic compounds of therapeutic interest, amenable to automatization.

专利号:WO-2025119975-A1
优先权日:2023-12-04
标 题:A method for synthesis of harmine
发明人：HETT ROBERT; GRAB HANUSCH; LAGOUTTE ROMAN
权利人:RECONNECT LABS AG
摘要:The invention relates to a method of synthesis of a compound of formula (I), harmine, according to the method comprising a step of transforming the compound of formula (II), into the compound of formula (I). The invention further relates to a compound of formula (II), which is an intermediate in synthesis of harmine according to the present invention.

专利号:WO-2024068853-A1
优先权日:2022-09-30
标题 :Improved synthesis of otviciclib
发明人：HUBER LUKAS A; GSTACH HUBERT; MASTALIR MATTHIAS; LEBAN JOHANN
权利人:MEDIZINISCHE UNIV INNSBRUCK
摘要:The present invention relates to an improved synthesis of Otviciclib (N-{4-[l-(2,6-Dichloro-4- sulfamoyl-phenyl)-3-dimethylamino-4-oxo-4,5-dihydro-lH-pyrazolo[3,4-d]pyrimidin-6- ylmethyl]-phenyl}-2-diethylamino-acetamide) and its derivatives, and furthermore relates to intermediates useful in this synthesis.

专利号:US-2024336586-A1
优先权日:2021-07-29
标题:Methods for synthesis of racemic, scalemic, and chiral alpha-tocotrienol quinone
发明人：GIANNOUSIS PETER; MOLLARD PAUL; GOUDEDRANCHE SEBASTIEN; KARASAWA TOMOYA
权利人:PTC THERAPEUTICS INC
摘要:The application discloses methods useful for the synthesis of racemic, scalemic, and chiral alpha-tocotrienol quinone, including synthetic intermediates and methods for making said synthetic intermediates.

专利号:US-2023002312-A1
优先权日:2019-11-20
标题:A continuous flow process for the synthesis of hydroxamic acid
发明人：PIMPALE MILIND JAGANNATH; KINI PRASHANT VASANT
权利人:UPL LTD
摘要:The present invention relates to a process for the synthesis of hydroxamic acids by continuous flow process wherein said process comprising reacting alkyl ester with hydroxyl amine salt in presence of base in a microreactor system and continuously producing hydroxamic acid.

专利号:US-10793495-B2
优先权日:2015-08-14
标 题:Synthesis of polyaryl substituted aryl compounds
发明人：BOULOS RAMIZ; FEUTRILL JOHN
权利人:BOULOS & COOPER PHARMACEUTICALS PTY LTD
摘要:A method for the synthesis of a aryl compound of Formula (1).n nU T-W—R 1 ) n    (1)