CAS: 130848-06-5; (S)-8,8-Dimethyl-2-Oxo-7,8-Dihydro-2H,6H-Pyrano[3,2-G]Chromen-7-Yl (Z)-2-Methylbut-2-Enoate

该化合物是一种化学化合物,被归类为自然产品,具体而言,是一种古草素衍生物,主要来自阿皮亚塞家族的植物,特别是安杰利卡吉达的根部;该化合物的特点是独特的结构,包括一种非古素和天使酯类;Decursinol 天使展示了各种生物活动,包括抗食性,抗氧化剂和潜在的抗癌特性,这使得它对药理学研究感兴趣.其溶液一般在有机溶剂中比较中,水溶性可能有限.该化合物的稳定性可能受到光和温度等环境因素的影响.与许多天然产品一样,其提取和净化可能很复杂,往往需要特定的方法将其与植物基体隔开.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

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上下游产品

日本前胡醇 Decursinol 23458-02-8

合成工艺路线路线简述

    📜3,3-二甲基丙烯酸置于jacobsen'S Catalyst 吡啶,4-二甲氨基吡啶,Lithium Aluminium Tetrahydride,Oxone,甲烷磺酸,四丁基硫酸氢铵,Phosphorus Pentoxide,碳酸氢钠,对甲苯磺酸,N,N'-二环己基碳二亚胺,Zinc(II) Chloride体系中,用 四氢呋喃,二氯甲烷,乙腈 用作溶剂,化学反应 5.0H,反应生成紫花前胡醇当归酸酯
    参考文献:Enantioselective Syntheses Of Decursinol Angelate And Decursin
    标题:Enantioselective Syntheses Of Decursinol Angelate And Decursin
    摘要:The Practical Enantioselective Syntheses Of Decursinol Angelate And Decursin Were Achieved In Eight Steps From Resorcinol. The Stereochemistry Was Addressed Using The Catalytic Asymmetric Epoxidation Of 7-Acetoxy-2,2-Dimethylchromene By Chiral (Salen)Mn Complexes As The Key Step. (C) 2001 Elsevier Science Ltd. All Rights Reserved.
    Doi:10.1016/s0040-4039(01)00642-6

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    主要参考文献


    1: Kim S, Kim JE, Kim N, Joo M, Lee MW, Jeon HJ, Ryu H, Song IC, Song GY, Lee HJ. Decursin inhibits tumor growth, migration, and invasion in gastric cancer by down-regulating CXCR7 expression. Am J Cancer Res. 2019 Sep 1;9(9):2007-2018. eCollection 2019.
    2: Chang SN, Khan I, Dey DK, Cho KH, Hwang BS, Bae KB, Kang SC, Park JG. Decursinol angelate ameliorates 12-O-tetradecanoyl phorbol-13-acetate (TPA) -induced NF-κB activation on mice ears by inhibiting exaggerated inflammatory cell infiltration, oxidative stress and pro-inflammatory cytokine production. Food Chem Toxicol. 2019 Oct;132:110699. doi: 10.1016/j.fct.2019.110699. Epub 2019 Jul 24. pii: E272. doi: 10.3390/biom9070272.
    4: Kiyonga AN, An JH, Lee KY, Lim C, Suh YG, Chin YW, Jung K. Rapid and Efficient Separation of Decursin and Decursinol Angelate from Angelica gigas Nakai using Ionic Liquid, (BMIm)BF(4), Combined with Crystallization. Molecules. 2019 Jun 28;24(13). pii: E2390. doi: 10.3390/molecules24132390.

    合成参考文献


    摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
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