专利号:US-2024116890-A1 优先权日:2022-09-28 标 题 :Large scale synthesis of cannabinol 发明人:COLLINS ARIANNA C; CRUCES IVAN; RAY KYLE; CRUCES WESTLEY 权利人:COLORADO CHROMATOGRAPY LLC 摘要:Methods for producing cannabinol, cannabivarin, or derivatives thereof are disclosed. The methods disclosed herein can be employed for large scale synthesis or semi-synthesis of the compounds, including multi-kilogram quantities of the compounds.
专利号:US-9518047-B2 优先权日:2013-10-17 标题 :Process for the industrial synthesis of lurasidone 发明人:ANGELINI TOMMASO; BETTONI PIERGIORGIO; ROLETTO JACOPO; PAISSONI PAOLO 权利人:PROCOS SPA 摘要:Disclosed is a process for the industrial synthesis of Lurasidone from (1R,2R)-cyclohexane-1,2-diyldimethanol (1), 3-(piperazin-1-yl)benzo[d]isothiazole (3) and (3aR,4R,7R,7aS)-3a,4,7,7a-tetrahydro-4,7-methanoisobenzofuran-1,3-dione (6).). Said process is optimised to obtain Lurasidone with high yields and high purities by preparing highly pure synthesis intermediates, using critical raw materials and reagents in amounts close to the stoichiometric amounts, increasing productivity and reducing the costs and environmental impact of the process.
专利号:WO-2025134140-A1 优先权日:2023-12-19 标题:A method for the synthesis of substituted anthranilic amide compounds, intermediates and salts thereof 发明人:MALVIYA NITIN JAIKANT; SINGH VIPENDER; SHAH JIGARKUMAR HARKISHANDAS; KALE MANOJ GANPAT; KAVITAKE SANTOSH GIRIDHAR; BORHADE AJIT SAHEBRAO; KLAUSENER ALEXANDER G M 权利人:PI INDUSTRIES LTD 摘要:The present invention discloses a method for the synthesis of compounds of formula (I) or a salt thereof, wherein, R is selected from hydrogen, halogen, cyano, C1-C12 alkyl, C1-C12 haloalkyl, C1-C12 alkoxy, C1-C12 haloalkoxy, or C3-C8 cycloalkyl; R4 is selected from hydrogen, C1-C12 alkyl, C2-C12 alkenyl, C2-C12 alkynyl, C1-C12 haloalkyl, C2-C12 haloalkenyl, C2-C12 haloalkynyl, C1-C12 alkoxy, C1-C12 haloalkoxy, C3-C8 cycloalkyl, or C3-C8 cycloalkyl-C1-C10 alkyl; and n represents an integer selected from 0-4. The method further comprises the synthesis of an anthranilic diamide compound of formula (A).
专利号:WO-2025057193-A1 优先权日:2023-09-13 标题:A method for the synthesis of substituted anthranilic amide compounds, intermediates and salts thereof 发明人:MALVIYA NITIN JAIKANT; SINGH VIPENDER; KALE MANOJ GANPAT; SHAH JIGARKUMAR HARKISHANDAS; GAVHANE KISHOR BAPU; KAVITAKE SANTOSH GIRIDHAR; BORHADE AJIT SAHEBRAO; KLAUSENER ALEXANDER G M 权利人:PI INDUSTRIES LTD 摘要:The present invention provides a method for the synthesis of compounds of formula (I), intermediates, and salts thereof, formula (I) wherein, R, R1 and n are as described in the description. The method further comprises the synthesis of anthranilic diamide compounds of formula (E), wherein the formula (E) is described in the description.
专利号:WO-2025134143-A1 优先权日:2023-12-19 标题 :A method for the synthesis of substituted anthranilic amide compounds, intermediates and salts thereof 发明人:MALVIYA NITIN JAIKANT; SINGH VIPENDER; MAL SANJIB; YADAV SANTOSH; SHAH JIGARKUMAR HARKISHANDAS; KAVITAKE SANTOSH GIRIDHAR; BORHADE AJIT SAHEBRAO; KLAUSENER ALEXANDER G M 权利人:PI INDUSTRIES LTD 摘要:The present invention discloses a method for the synthesis of compounds of formula (I) or a salt thereof, wherein R is selected from hydrogen, halogen, cyano, C1-C12 alkyl, C1-C12 haloalkyl, C1-C12 alkoxy, C1-C12 haloalkoxy, or C3-C8 cycloalkyl; R4 is selected from hydrogen, C1-C12 alkyl, C2-C12 alkenyl, C2-C12 alkynyl, C1-C12 haloalkyl, C2- C12 haloalkenyl, C2-C12 haloalkynyl, C1-C12 alkoxy, C1-C12 haloalkoxy, C3-C8 cycloalkyl, or C3-C8 cycloalkyl-C1-C10 alkyl; and n represents an integer selected from 0-4. The process further comprises the synthesis of an anthranilic diamide compound of formula (A).
专利号:US-12240808-B2 优先权日:2021-05-28 标 题 :Process for the synthesis of calebin-a and its intermediates 发明人:MAJEED MUHAMMED; NAGABHUSHANAM KALYANAM; MUTHUKAMAN NAGARAJAN; NAIDU PENTAKOTA PARADESI 权利人:MAJEED MUHAMMED; NAGABHUSHANAM KALYANAM; MUTHUKAMAN NAGARAJAN; NAIDU PENTAKOTA PARADESI 摘要:The invention discloses novel intermediates in the synthesis of Calebin A represented by formula 3. The invention also covers processes for the synthesis of Calebin-A and its analogs using compounds of formula 3.
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