CAS: 112898-00-7; Fmoc-D-Glutamine

该化合物是一种受保护的氨基酸衍生物,通常用于丙化物合成.该化合物在α-氨基功能中具有氟化物(9-氟化烃-2-碳基碳基)保护组的特点,确保在温和基本条件下有选择地减少保护.碳基汞的侧链会提高溶性,并为进一步功能化提供把手.它的立体化学纯度(R-configation)对于手淫化物设计的应用至关重要. Fmoc 组的正态性允许与酸液保护策略兼容,使其在固相聚物合成(SPS)中具有价值. 这种化合物在药用化学和生物合成中特别有用,因为受控的再活性和高产量是必不可少的.

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71989-20-3 102747-84-2 132327-80-1

物理性质

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C&L通报

上下游产品

N-Fm°C-glutamine4-Carbamoyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)-butyric acid 2,4,5-trichloro-phenyl ester 88H134N12O16SC88H134N12O16S 44H77N9O9C44H77N9O9

合成工艺路线路线简述

    📜N-Fmoc-Glutamine置于chiral Column Based On 3,5-Dimethylphenylcarbamoylated β-Cyclodextrin Combining Cinchona Alkaloid Immobilized On Silica Gel体系中,用 甲醇,甲酸,三乙胺,乙腈 用作溶剂,化学反应生成Fmoc-L-谷氨酰胺,Fmoc-L-谷氨酰胺
    参考文献:基于3,5-二甲基苯基氨基甲酰基化的β-环糊精结合金鸡纳生物碱部分的新型手性固定相.
    标题:基于3,5-二甲基苯基氨基甲酰基化的β-环糊精结合金鸡纳生物碱部分的新型手性固定相.
    摘要:合成了基于3,5-二甲基苯基氨基甲酰基化的β-环糊精连接奎宁(qn)或奎尼丁(qd)部分的新型手性选择剂,并将其固定在硅胶上.通过与3,5-二甲基苯基氨基甲酰基化的β-环糊精(β-Cd)手性固定相(csp)和9-O-(叔)进行比较,研究了它们的色谱性能.-丁基氨基甲酰基)-基于qn的csp(qn-Ax).在csp上评估了fmoc保护的氨基酸,手性药物cloprostenol(已成功用于兽医学)和中性手性分析物,结果表明,这种新型csp既具有cd基csp的对映体分离能力,又具有qn /与基于β-Cd的csp或基于qn / Qd的csp相比,基于qd的csp具有更广泛的应用范围.发现qn / Qd部分在fmoc-氨基酸的整个对映体分离过程中起主导作用,并伴随有β-Cd部分的协同作用,从而导致基于β-Cd-Qn的csp和β的不同对映体分离基于cd-Qd的csp.此外,
    Doi:10.1002/chir.23237

    海关参考信息

    专利信息


    专利号:US-8598089-B2
    优先权日:2003-12-17
    标题 :Methods for synthesis of encoded libraries
    发明人：MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A
    权利人:MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A; GLAXOSMITHKLINE LLC
    摘要:The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.

    专利号:US-8410028-B2
    优先权日:2003-12-17
    标 题:Methods for synthesis of encoded libraries
    发明人：MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A
    权利人:MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A; GLAXOSMITHKLINE LLC
    摘要:The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.

    专利号:US-2007042401-A1
    优先权日:2003-12-17
    标题 :Methods for synthesis of encoded libraries

    专利号:US-2012245040-A1
    优先权日:2003-12-17
    标题 :Methods for synthesis of encoded libraries

    专利号:US-2009062147-A1
    优先权日:2003-12-17
    标 题:Methods for synthesis of encoded libraries

    专利号:US-7972994-B2
    优先权日:2003-12-17
    标 题 :Methods for synthesis of encoded libraries

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    主要参考文献

    参考标题:Rational Design And Synthesis Of Modified Teixobactin Analogues: In Vitro Antibacterial Activity Against Staphylococcus Aureus , Propionibacterium Acnes And Pseudomonas Aeruginosa
    作者:Vivian Ng,Sarah A. Kuehne,Weng C. Chan |发布日期:2018.6.26
    摘要:Extensive Antimicrobial Susceptibility Assessment Against A Panel Of Clinically Relevant Staphylococcus Aureus And Propionibacterium Acnes Strains Led To The Identification Of The New Lead Compound, [arg(Me)10,Nle11]Teixobactin, With An Excellent Bactericidal Activity (Minimum Inhibitory Concentration (Mic)=2-4 μg Ml−1). Significantly, The Antimicrobial Activity Of Several Of The Teixobactin Analogues Against

    合成参考文献


    参考文献:10.1023/a:1008349424452
    摘要:Groth M, Malicka J, Czaplewski C, Ołdziej S, Łankiewicz L, Wiczk W, Liwo A. Maximum entropy approach to the determination of solution conformation of flexible polypeptides by global conformational analysis and NMR spectroscopy – Application to DNS1-c-[d-A2bu2, Trp4,Leu5]- enkephalin and DNS1-c-[d-A2bu2, Trp4, d-Leu5]enkephalin. Journal of Biomolecular NMR. 1999 Dec;15(4):315–30. doi: 10.1023/a:1008349424452.
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