月桂酰胺置于盐酸,Disodium Hydrogenphosphate体系中,用 水,乙腈 用作溶剂,化学反应 4.0H,反应生成月桂酸甲酯 参考文献:The Conversion Of Amides To Esters With Meerwein'S Reagent. Application To The Synthesis Of A Carfentanil Precursor. 标题:The Conversion Of Amides To Esters With Meerwein'S Reagent. Application To The Synthesis Of A Carfentanil Precursor. 摘要:An Efficient Two Step Transformation Of 1 Degrees And 2 Degrees Amides To Methyl And Ethyl Esters Has Been Developed Using Trimethyl-And Triethyloxonium Tetrafluoroborates,And Dilute Acid. This Methodology Was Applied To 1-Benzyl-4-Phenylamino-4-Piperidinecarboxamide Precursor In The Synthesis Of Carfentanil,To Produce The Methyl Ester In 60% Yield And The Ethyl Ester In 80% Yield. Doi:10.1080/00397919708004212
专利号:EP-1641812-B1 优先权日:2003-06-30 标题 :PURE d-(17alpha)-13-ETHYL-17-HYDROXY-18,19-DINORPREGN-4-ENE-20-YNE-3-ONE-3E- AND -3Z-OXIME ISOMERS, AS WELL AS PROCESS FOR THE SYNTHESIS OF THE MIXTURE OF ISOMERS AND THE PURE ISOMERS 发明人:TUBA ZOLTAN; MAHO SANDOR; KESERU GYOERGY; KOZMA JOZSEF; HORVATH JANOS; BALOGH GABOR 权利人:RICHTER GEDEON NYRT 摘要:The invention relates to the pure d-(17alpha)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-Â20-yne-3-one-3E-oxime isomer of formula (IA), the pure d-(17alpha)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yne-3-one-3Z-oxime isomer of formula (IB), which are of gestagen activity, as well as the process for the synthesis of the mixture of the above isomers and the pure isomers. The invention also relates to the pharmaceutical compositions - and the process for their synthesis - which contain either the pure isomer of formula (IA) or the pure isomer of formula (IB) as active ingredient as such or in combination with other active ingredients (for example an oestrogen agent) together with pharmaceutical auxiliary materials commonly used in practice.
专利号:US-2004249114-A1 优先权日:2001-02-06 标题 :Methods of synthesis of polysuccinimide or polyaspartate by end capping polymerization 发明人:SWIFT GRAHAM; REDLICH GEORGE H; WEHBY JOHN NOLAN 摘要:Disclosed are methods of synthesis of homopolymers or copolymers containing succinimide or aspartate moieties formed in the presence of an end capping initiator. Also disclosed are methods of isolating, compounding, stabilizing and processing the homopolymers and copolymers.
专利号:US-2006211843-A1 优先权日:2001-02-06 标题:Methods of synthesis of poly(succinimide-aspartate) polysuccinimide or polyaspartate by end capping polymerization 发明人:SWIFT GRAHAM; REDLICH GEORGE H 权利人:SWIFT GRAHAM; REDLICH GEORGE H 摘要:Disclosed are methods of synthesis of homopolymers or copolymers containing succinimide or aspartate moieties formed in the presence of an end capping initiator. Also disclosed are methods of isolating, compounding, stabilizing and processing the homopolymers and copolymers.
专利号:US-5872245-A 优先权日:1992-09-30 标题 :Continuous process for the synthesis of sucrose fatty acid esters 发明人:WILSON DONALD C 权利人:OPTIMA TECHNOLOGIES GROUP 摘要:This present invention pertains to a process for the synthesis of sucrose fatty acid esters by reacting sucrose and a purified specific fatty acid ester under substantially solvent free conditions in the presence of a transesterification stationary catalyst and mechanical emulsification. The process is continuous, yielding selected individual products of separated simple sucrose fatty acid esters of mono-, di-, tri- and polyesters while recycling the unwanted ester fractions, the unreacted sucrose and fatty acid ester.
专利号:US-2004249115-A1 优先权日:2001-02-06 标题 :Methods of synthesis of poly(succinimide-aspartate) copolymer by end-capping polymerization 发明人:SWIFT GRAHAM; REDLICH GEORGE H 摘要:Disclosed are methods of synthesis of copoly(succinimide-aspartate), copolymers and derivatives thereof, prepared in a thermal or supercritical fluid method in the presence of an end capping initiator. Also disclosed are methods of isolating, compounding, stabilizing and processing the copoly(succinimide-aspartate), and its derivatives.
专利号:US-8647848-B2 优先权日:2008-06-13 标题:Enzymatic synthesis of sphingolipids 发明人:HOLLMANN FRANK; THUM OLIVER; TOELLE CHRISTOPH; PROVINZANO ANGELO; KOREVAAR CORNELIS GERRIT NIJS 权利人:HOLLMANN FRANK; THUM OLIVER; TOELLE CHRISTOPH; PROVINZANO ANGELO; KOREVAAR CORNELIS GERRIT NIJS; EVONIK GOLDSCHMIDT GMBH 摘要:The invention relates to the enzymatic synthesis of sphingolipids and compositions that contain sphingolipids from lysosphingolipids and carbonic esters, and to cosmetic, dermatological or pharmaceutical formulations containing said sphingolipids or compositions.
[参考文献]: Yongwang, Et Al. Comparison Of Two Different Processes To Synthesize Biodiesel By Waste Cooking Oil. Journal Of Molecular Catalysis A: Chemical. Volume 252, Issues 1–2, 1 June 2006, Pages 107-112 [参考文献]: Brian D Fitz, Et Al. Evaluation Of Injection Methods For Fast, High Peak Capacity Separations With Low Thermal Mass Gas Chromatography. J Chromatogr A. 2015 May 1:1392:82-90. [参考文献]: Dong-Kyu Lee, Et Al. Non-Invasive Characterization Of The Adipogenic Differentiation Of Human Bone Marrow-Derived Mesenchymal Stromal Cells By Hs-Spme/gc-Ms. Sci Rep. 2014 Oct 9:4:6550. [参考文献]: Jitender Sharma, Et Al. Enzymatic Chemoselective Synthesis Of Secondary-Amide Surfactant From N-Methylethanol Amine. J Biosci Bioeng. 2005 Dec;100(6):662-6. [参考文献]: Matthias Onghena, Et Al. Development And Application Of A Non-Targeted Extraction Method For The Analysis Of Migrating Compounds From Plastic Baby Bottles By Gc-Ms. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2014;31(12):2090-102.