CAS: 104721-52-0; 4-[6-Carboxy-9-Fluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-De]-1,4-Benzoxazin-10-Yl]-1-Methylpiperazine 1-Oxide

上下游产品

ofloxacin

📜氧氟沙星置于双氧水体系中,用 水 用作溶剂,化学反应生成9-氟-3-甲基-10-(4-甲基-4-氧代-1-哌嗪基)-7-氧代-2,3-二氢-7H-[1,4]恶嗪并[2,3,4-Ij]喹啉-6-羧酸乙酸盐(1:1)
参考文献:N-Oxides As Antibacterial Agents
标题:N-Oxides As Antibacterial Agents
摘要:这项发明涉及基于被喹诺酮羧酸或萘喹啉酮羧酸取代的饱和氮杂环的n-氧化物的新抗菌组合物,特别是口服组合物,以及新的活性化合物及其制备方法.

专利信息

专利号:US-2006111369-A1
优先权日:2004-11-10
标 题:Synthesis, characterization and biological action of optically active isomers of floxacins
发明人：SOMBERG JOHN C; RANADE VASANT V
权利人:SOMBERG JOHN C; RANADE VASANT V
摘要:Disclosed herein is the method for synthesis and separation of enantiospecific isomers of floxacins. These isomers can be used to study the antibacterial action, as well as cardiac effects, such as arrhythmogenic activity, QT internal prolongation and dispersion, and Ikr inhibition in humans. A method for the identification of chiral isolates of the floxacins that are devoid or possess less QT prolonging action and thus cause less arthropathy especially of the Torsades de pointes variety. Also disclosed are methods for assaying these isomeric compounds present in the biological fluids.

专利号:WO-2006052264-A2
优先权日:2004-11-10
标 题:Synthesis, characterization and biological action of optically active isomers of floxacins