CAS: 1015474-32-4; 3-(5-Amino-2-Methyl-4-Oxoquinazolin-3(4H)-yl)Piperidine-2,6-Dione

相似化合物

1620018-93-0 2242744-48-3 2154341-75-8

上下游产品

3-(2-Methyl-5-Nitro-4-Oxo-4H-Quinazolin-3-yl)-Piperidine-2,6-Dione 1015474-86-8

📜3-氨基-2,6-哌啶二酮盐酸盐置于咪唑,10 Wt% Pd(Oh)2 On Carbon,氢气体系中,用 N,N-二甲基甲酰胺,乙腈 用作溶剂,化学反应 48.0H,反应生成3-(5-氨基-2-甲基-4-氧喹唑啉-3(4H)-基)哌啶-2,6-二酮
参考文献: Bromodomain Targeting Degronimers For Target Protein Degradation[fr] Dégronimères Ciblant Un Bromodomaine Pour La Dégradation De Protéines Cibles
标题: Bromodomain Targeting Degronimers For Target Protein Degradation[fr] Dégronimères Ciblant Un Bromodomaine Pour La Dégradation De Protéines Cibles
摘要:这项发明提供了一种degronimer,它具有可与靶向配体连接的e3泛素连接酶靶向部位(degron),该靶向配体选择用于体内降解溴结构域蛋白以实现治疗效果,并提供了使用方法,组合物以及它们的制备方法.

专利信息

专利号:US-12441733-B2
优先权日:2018-03-26
标题:Substituted 2,4-dioxotetrahydropyrimidines as intermediates in the synthesis of bruton's tyrosine kinase inhibitors
发明人：ARISTA LUCA; HEBACH CHRISTINA; HOLLINGWORTH GREGORY JOHN; HOLZER PHILIPP; IMBACH-WEESE PATRICIA; LORBER JULIEN; MACHAUER RAINER; SCHMIEDEBERG NIKO; VULPETTI ANNA; ZOLLER THOMAS
权利人:NOVARTIS AG
摘要:The invention relates to compounds of the formulae (I), (III), (IIIa), (XXIa), (XXIII), and/or (XLVI)or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to use of the compounds in the treatment of disease.

专利号:US-9303014-B2
优先权日:2013-05-01
标题:Synthesis of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione
发明人：RUCHELMAN ALEXANDER L; COHEN BENJAMIN M; CHOUDHURY ANUSUYA; KREILEIN MATTHEW M; LEONG WILLIAM W; MAN HON-WAH
权利人:CELGENE CORP
摘要:Provided herein are processes for the preparation of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione, or an enantiomer or a mixture of enantiomers thereof; or a pharmaceutically acceptable salt thereof.

专利号:US-11623929-B2
优先权日:2018-06-04
标 题 :Spirocyclic compounds
发明人：NASVESCHUK CHRISTOPHER G; DEY FABIAN; GOERGLER ANNICK; NORCROSS ROGER; SCHMID PHILIPP
权利人:C4 THERAPEUTICS INC
摘要:The present invention provides compounds and intermediates. The present invention also provides compounds which bind to the ubiquitously expressed E3 ligase protein cereblon (CRBN) and their use for the treatment of abnormal cellular proliferation. The present invention also provides compounds that may be used as synthetic intermediates in the synthesis of bifunctional compounds used for targeted protein degradation.

专利号:US-9067912-B2
优先权日:2013-05-01
标 题 :Synthesis of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,8-dione

专利号:CA-2910971-A1
优先权日:2013-05-01
标题:Synthesis of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4h)-yl)piperidine-2,6-dione

专利号:US-2016009685-A1
优先权日:2013-05-01
标 题 :Synthesis of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4h)-yl)piperidine-2,6-dione