CAS: 1012341-48-8; (R,E)-5-([1,1'-Biphenyl]-4-yl)-4-((Tert-Butoxycarbonyl)Amino)-2-Methylpent-2-Enoic Acid

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1015037-46-3 2131788-25-3 149709-59-1

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CAS号149709-59-1 (R,E)-5-((1,1-联...

N-叔丁基氧基羰基-氨基-4,4-联苯-R-丙氨酸甲酯置于甲醇,Sodium Hypochlorite,Sodium Tetrahydroborate,乙醇,Lithium Hydroxide体系中,用 四氢呋喃 用作溶剂,化学反应 9.5H,反应生成(R,E)-5-([1,1'-联苯]-4-基)-4-[(叔丁氧羰基)氨基]-2-甲基-2-戊烯酸
参考文献:一种ahu377钙盐的合成方法
标题:一种ahu377钙盐的合成方法
摘要:本发明公开了一种ahu377钙盐的合成方法,将4‑溴‑d‑苯丙氨酸与氯化亚砜反应,所得的4‑溴‑d‑苯丙氨酸甲酯盐酸盐与boc酸酐反应后,再与苯基溴化镁反应得到的 N‑叔丁基氧基羰基‑氨基‑4,4‑联苯‑r‑丙氨酸甲酯,其与硼氢化钠反应后,再与乙氧甲酰基亚乙基三苯基膦反应得 (4R)‑5‑[1,1'‑联苯]‑4‑基‑4‑[[叔丁氧羰基]氨基]‑2‑甲基‑2‑戊烯酸乙酯,再与氢氧化锂反应,加氢催化后与氯化亚砜反应得到(2R,4S)‑5‑([1,1‑联苯基)‑4‑氨基‑2‑甲基戊酸乙酯盐酸盐,再将其与氯化钙和丁二酸酐搅拌反应得到本产品.步骤相对简单,反应条件比较温和,纯度高,收率高.

专利信息

专利号:US-11161803-B2
优先权日:2017-04-28
标题:Ammonium carboxylate compound, crystalline form, amorphous form and preparation method thereof
发明人：ZHANG BO; DING XIAOHUA; DAI DONGCHENG; LEI SIJUN; LIU XUEMING; DUAN PANPAN; CHEN YONGKAI; WANG CHAODONG
权利人:WUHAN LL SCIENCE & TECHNOLOGY DEVELOPMENT CO LTD
摘要:The present disclosure belongs to the field of chemical synthesis, and in particular relates to an ammonium carboxylate compound, a crystalline form and an amorphous form, and a preparation method thereof. The present disclosure prepares the compound and the crystalline form I and its single crystal, amorphous form and crystalline form II thereof. The compound, the crystalline forms, the single crystal and the amorphous form can stably exist and exhibit good solid forms, suitable for medicine-making. Furthermore, these products possess high purity and less single impurity. Moreover, the preparation methods of the present disclosure are easy to implement due to the simple processes with mild reaction conditions, and could produce products of high yield and high purity without complex purification steps. Furthermore, the preparation methods may facilitate safety, environmental protection, and industrial production.

专利号:CN-118291560-A
优先权日:2024-04-10
标 题:Synthesis method of sabatier intermediate (2R, 4S) -5- ([ 1,1' -biphenyl ] -4-yl) -4- ((tert-butoxycarbonyl) amino) -2-methyl ethyl valerate