CAS: 933190-51-3; 8-Bromo-6-Chloroimidazo[1,2-B]Pyridazine

该化合物是一种混合循环化合物,其内有8个和6个位置分别含有溴和氯替代成分的聚二氮[1,2b]pyridazine核心,具有溴和氯的替代成分.这一结构具有重要的回活动性,使它成为制药和农用化学合成中有价值的中间体.卤素原子的存在增强了其在交叉反应中的效用,如Suzuki或Buchwald-Hartwig交织,使得目标分子的开发能够精确地实现功能化.在标准条件下,它的高纯度和稳定性确保了研究和工业应用的可靠性能.该化合物由于其模块性反应和与多种合成途径的兼容性,在药用化学设计生物活性分子方面特别有用.

英文名称8-Bromo-6-Chloroimidazo[1,2-B]Pyridazine
中文名称8-溴-6-氯咪唑并[1,2-B]哒嗪
IUPAC名称8-bromo-6-chloroimidazo[1,2-b]pyridazine
其它别名6-氯-8-溴咪唑并[1,2-B]哒嗪; 8-Bromo-6-Chloroimidazo[1
CAS编号933190-51-3
MFCD编号:MFCD11520890
EINECS号:183-280-8
分子式:C6H3BrClN3
分子量:232.47
产品CID: 1971440
产品分类有机原料→分子砌块→芳杂环类化合物→哒嗪类化合物

相似结构搜索
InChIKey: LZEJQXOCRMRVNP-UHFFFAOYSA-N
InChI=1S/C6H3BrClN3/c7-4-3-5(8)10-11-2-1-9-6(4)11/h1-3H…
计算化学: 氢键受体数3.0氢键供体数0.0可旋转键数0.0

相似化合物

933035-31-5 1298031-94-3 1263425-59-7

MSDS等安全信息

GHS符号GHS07
危险类别急性毒性类别4(经口)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
警示词Warning
危险描述H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
安全声明H303+H313+H333

欧盟法规

C&L通报

上下游产品

CAS号446273-59-2 3-氨基-4-溴-6-氯哒嗪 | CAS号621-62-5 氯乙醛缩二乙醇 | CAS号107-20-0 一氯乙醛

合成工艺路线路线简述

446273-59-2 = 933190-51-3
反应条件:1.1 Solvents: Ethanol; 22 H,50 °C; 50 °C -> Rt
标题:Binding To An Unusual Inactive Kinase Conformation By Highly Selective Inhibitors Of Inositol-Requiring Enzyme 1α Kinase-Endoribonuclease
作者:Colombano,Giampiero; Caldwell,John J.; Matthews,Thomas P.; Bhatia,Chitra; Joshi,Amar; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2019 卷标:62(5) 页码:2447-2465]

446273-59-2 = 933190-51-3
反应条件:1.1 Solvents: Ethanol,Water; 16 H,Rt -> 100 °C
标题:Biaryl Amide Compounds As Kinase Inhibitors And Their Preparation
参考文献:World Intellectual Property Organization]

446273-59-2 = 933190-51-3
反应条件:1.1 Solvents: Water; Overnight,95 °C; Cooled1.2 Reagents: Sodium Bicarbonate; Ph 7,Cooled
标题:Tricyclic Heterocyclic Compounds As Kinase Inhibitors And Their Preparation
参考文献:World Intellectual Property Organization]

446273-59-2 = 933190-51-3
反应条件:1.1 Solvents: Ethanol; 15 H,Reflux
标题:Bicyclic Piperazine Compounds As Btk Inhibitors And Their Preparation
参考文献:World Intellectual Property Organization]

446273-59-2 = 933190-51-3
反应条件:1.1 Solvents: Ethanol; Overnight,Reflux; Reflux -> Rt1.2 Reagents: Ammonia; Ph 8,0 - 5 °C
标题:Preparation Of Bicyclic Heterocyclic Compounds As Kinase Modulators
参考文献:World Intellectual Property Organization]

= 933190-51-3 [标题:Reaction Conditions
标题:Cyclic Di-Nucleotide Compounds As Sting Agonists
参考文献:World Intellectual Property Organization]

446273-59-2 = 933190-51-3 + 1161847-29-5
反应条件:1.1 Solvents: Ethanol,Water; Rt; 2 H,Reflux; Reflux -> Rt1.2 Reagents: Sodium Carbonate Solvents: Ethyl Acetate,Water; Basified,Cooled
标题:Imidazo[1,2-B]Pyridazine Derivatives As Pde10 Inhibitors And Their Preparation,Pharmaceutical Compositions And Use In The Treatment Of Cns Diseases
参考文献:United States]

446273-59-2 + 621-62-5 = 933190-51-3
反应条件:1.1 Reagents: P-Toluenesulfonic Acid Solvents: Isopropanol; 20 H,Rt -> 80 °C; 80 °C -> Rt1.2 Reagents: Sodium Bicarbonate Solvents: Water
标题:Imidazopyridazine Compounds As Syk Inhibitors And Their Preparation And Use In The Treatment Of Autoimmune And Inflammatory Diseases
参考文献:United States]

446273-59-2 + 621-62-5 = 933190-51-3
反应条件:1.1 Reagents: P-Toluenesulfonic Acid Solvents: Isopropanol; 20 H,Rt -> 80 °C
标题:Rational Design Of Highly Selective Spleen Tyrosine Kinase Inhibitors
作者:Lucas,Matthew C.; Goldstein,David M.; Hermann,Johannes C.; Kuglstatter,Andreas; Liu,Wenjian; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2012 卷标:55(23) 页码:10414-10423]

5469-69-2 = 933190-51-3
反应条件:1.1 Reagents: Sodium Bicarbonate,Bromine Solvents: Dichloromethane,1,4-Dioxane; 15 H,40 °C1.2 Solvents: Water; 15 H,45 °C
标题:Prpearation Of 6-Chloro-8-Bromoimidazo[1,2-B]Pyridazine
参考文献:China]

446273-59-2 = 933190-51-3
反应条件:1.1 Solvents: Ethyl Acetate; 24 H,Reflux
标题:Preparation Of 6-Aryl-Imidazo[1,2-B]Pyridazine Derivatives As Antitumor Agents
参考文献:China]

446273-59-2 = 933190-51-3
反应条件:1.1 Solvents: Water; Overnight,50 °C
标题:Preparation Of Imidazopyridazinyl Compounds As Cyp17 Inhibitors Useful In Treating Cancer
参考文献:World Intellectual Property Organization]

446273-59-2 + 621-62-5 = 933190-51-3
反应条件:1.1 Reagents: P-Toluenesulfonic Acid Solvents: Isopropanol; 20 H,Reflux
标题:Preparation Of Imidazopyridazine And Imidazopyrazine Compounds As Inhibitors Of Cdk7
参考文献:World Intellectual Property Organization]

446273-59-2 = 933190-51-3
反应条件:1.1 Solvents: Isopropanol,Water; 15 H,110 °C1.2 Reagents: Sodium Carbonate Solvents: Water; Ph 8
标题:Macrocyclic Urea Orexin Receptor Agonists
参考文献:World Intellectual Property Organization]

446273-59-2 = 933190-51-3
反应条件:1.1 Solvents: Ethanol; 24 - 48 H,Reflux
标题:Design,Synthesis,And Biological Evaluation Of Imidazo[1,2-B]Pyridazine Derivatives As Mtor Inhibitors
作者:Mao,Beibei; Gao,Shanyun; Weng,Yiran; Zhang,Liangren; Zhang,Lihe
参考文献:European Journal Of Medicinal Chemistry 日期:2017 卷标:129 页码:135-150]

= 933190-51-3 [标题:Reaction Conditions
标题:Preparation Of Substituted Pyrrolopyridinones As Hpk1 Antagonists And Uses Thereof
参考文献:World Intellectual Property Organization]

= 933190-51-3 [标题:Reaction Conditions
标题:Imidazopyridazinyl Compounds
参考文献:United States

氯乙醛,3-氨基-4-溴-6-氯哒嗪置于乙醇,丙酮,乙酸乙酯,Brine,Sodium Sulfate-Iii体系中,用乙醇作为反应溶剂,化学反应 16.0H,以to Afford The Product,8-Bromo-6-Chloroimidazo[1,2-B]Pyridazine (D-3)的收率获得产物8-溴-6-氯咪唑并[1,2-B]哒嗪
参考文献:Heterocyclic Compounds And Uses Thereof
标题:Heterocyclic Compounds And Uses Thereof
摘要:本文描述了调节激酶活性(包括pi3激酶活性)的化合物和制药组合物,以及治疗与激酶活性(包括pi3激酶活性)相关的疾病和病症的化合物,制药组合物和治疗方法.

专利信息

专利号:US-9370515-B2
优先权日:2013-03-07
标题 :Mixed lineage kinase inhibitors and method of treatments
发明人：GOODFELLOW VAL S; NGUYEN THONG X; RAVULA SATHEESH B; GELBARD HARRIS A
权利人:CALIFIA BIO INC; UNIV ROCHESTER
摘要:Provided herein are imidazopyridine compounds having an inhibitory effect on mixed lineage kinases (MLKs), methods of their synthesis, and methods of their therapeutic. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and pharmaceutical compositions.

专利号:US-11685761-B2
优先权日:2017-12-20
标题:Cyclic di-nucleotide compounds as sting agonists
发明人：ANDRESEN BRIAN M; BENNETT FRANK; CHANG WONSUK; CHILDERS MATTHEW LLOYD; CUMMING JARED N; LIM JONGWON; LU MIN; TROTTER BENJAMIN WESLEY; WU WEN-LIAN
权利人:MERCK SHARP & DOHME; ANDRESEN BRIAN M; BENNETT FRANK; CHANG WONSUK; CHILDERS MATTHEW LLOYD; CUMMING JARED N; LIM JONGWON; LU MIN; TROTTER BENJAMIN WESLEY; WU WEN LIAN; MERCK SHARP & DOHME LLC
摘要:A class of polycyclic compounds of general formula (I), wherein Base1, Base2, Y, Za, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, R8a, and R9 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.

专利号:CN-105237541-A
优先权日:2015-09-29
标题 :Synthesis method of 6-cholro-8-bromoimidazole[1,2-b]pyridazine