CAS: 881-07-2; 2-Methyl-8-Nitroquinoline

该化合物是一种有机化合物,其特征是其基质结构,包括一个引信苯和环.一个甲基组位于第二位置,一个硝基罗组位于第八位置,这有其独特的化学特性.该化合物一般是黄色至橙色晶状固体,以其在包括制药和材料科学在内的各个领域的潜在用途而著称.它显示有机溶剂中具有中等溶解性,而水溶解度较低.硝基罗组引入了重要的电子提取特性,影响化合物的再活动性和稳定性.2-Mecy-8-nitoroquiline可以参与各种化学反应,包括电子替代和减少,使其成为合成有机化学中有价值的中间体.此外,其衍生物可能展示出生物活动,从而引起对医药化学的兴趣.与许多硝基化合物一样,必须处理2-Myjy-8-nitroquiline,同时顾及潜在的毒性和环境因素.

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18978-78-4 607-35-2 61854-62-4

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上下游产品

CAS号91-63-4 2-甲基喹啉 | CAS号123-73-9 2-丁烯醛 | CAS号88-74-4 2-硝基苯胺 | CAS号75-07-0 乙醛 | CAS号111-34-2 乙烯基正丁醚 | CAS号27337-58-2 1,10-Phenanthro... | CAS号18978-78-4 8-氨基喹哪啶 | CAS号15733-85-4 8-nitroquinolin... | CAS号3002-77-5 2-甲基-1,10-菲咯啉 | CAS号61388-89-4 N-(2-methylquin... | CAS号380153-78-6 tert-butyl N-(2...

合成工艺路线路线简述

    📜2-甲基-8-硝基喹啉-1-氧化物置于氯仿,三氯化磷体系中,化学反应生成 2-甲基-8-硝基喹啉
    参考文献:ochiai; Satake,Yakugaku Zasshi/journal Of The Pharmaceutical Society Of Japan,1951,Vol. 71,P. 1078,1079,1081
    标题:ochiai; Satake,Yakugaku Zasshi/journal Of The Pharmaceutical Society Of Japan,1951,Vol. 71,P. 1078,1079,1081

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    专利信息


    专利号:US-8735586-B2
    优先权日:2007-06-26
    标 题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles
    发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR
    权利人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR; SANOFI SA
    摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct copper catalyzed regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.

    专利号:EP-2173747-B1
    优先权日:2007-06-26
    标 题:A regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles
    发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARE MARC; R KYEN OMAR; URMANN MATHIAS; HALLAND NIS
    权利人:SANOFI SA
    摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, wherein R1; R2; R3; R4; J1; J2; J3; J4 and G have the meanings indicated in the claims. The present invention provides a direct metal, e.g. palladium or copper, catalyzed, regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.

    专利号:US-2010261909-A1
    优先权日:2007-06-26
    标题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles

    专利号:WO-2009000413-A1
    优先权日:2007-06-26
    标题:A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles

    专利号:CA-2693142-A1
    优先权日:2007-06-26
    标题:A regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles

    专利号:AU-2008267444-A1
    优先权日:2007-06-26
    标 题 :A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles

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    合成参考文献


    摘要:Sharma, U.; Parmar, D.; Sumit; Manisha, Science of Synthesis: Knowledge Updates, (2024) 2, 34.
    摘要:Sharma, U.; Parmar, D.; Sumit; Manisha, Science of Synthesis: Knowledge Updates, (2024) 2, 16.
    摘要:Sharma, U.; Parmar, D.; Sumit; Manisha, Science of Synthesis: Knowledge Updates, (2024) 2, 58.
    摘要:Sharma, U.; Parmar, D.; Sumit; Manisha, Science of Synthesis: Knowledge Updates, (2024) 2, 99.
    摘要:Sharma, U.; Parmar, D.; Sumit; Manisha, Science of Synthesis: Knowledge Updates, (2024) 2, 78.
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