CAS: 797762-11-9; 7-Ethyl-1,2,6,7-Tetrahydro-20-(S)-Camptothecin

英文名称7-Ethyl-1,2,6,7-Tetrahydro-20-(S)-Camptothecin
中文名称伊立替康杂质29
CAS编号797762-11-9
分子式:C22H24N2O4分子量:380.44
产品CID: 1791680
产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

相似结构搜索
InChIKey: ODRCYXFDOQLUMW-CVSRMHJLSA-N
1S/C22H24N2O4/c1-3-12-13-7-5-6-8-17(13)23-19-14(12)10-24-18(19)9-16-15(20(24)25)11-28-21(26)22(16,27)4-2/h5-9,12,14,19,23,27H,3-4,10-11H2,1-2H3/t12 ,14 ,19 ,22-/m0/s1
计算化学: 氢键受体数5.0氢键供体数2.0可旋转键数2.0

MSDS等安全信息

上下游产品

7-乙基喜树碱 7-Ethylcamptothecin 78287-27-1

合成工艺路线路线简述

📜7-乙基喜树碱置于platinum On Carbon 氢气,二甲基亚砜体系中,用溶剂黄146 作为反应溶剂,25.0~65.0 °C,500.01 Kpa 条件下,反应 43.5H,反应生成伊立替康杂质29
参考文献: The Method Of Manufacturing Of 7-Ethyl-10-Hydroxycamptothecin[fr] Procede De Fabrication De 7-Ethyl-10-Hydroxycamptothecine
标题: The Method Of Manufacturing Of 7-Ethyl-10-Hydroxycamptothecin[fr] Procede De Fabrication De 7-Ethyl-10-Hydroxycamptothecine
摘要:公式i的7-乙基-10-羟基喜树碱的制备方法的特征在于,使用从含有碘氧苯,碘氧苯酯,过碘酸钠,过碘酸钾,过硫酸钾和过硫酸铵的组合中选择的氧化剂,将公式iv的7-乙基-1,2,6,7-四氢喜树碱氧化,在由含有1至3个碳原子的饱和脂肪族一元羧酸和水组成的溶剂中进行.

海关参考信息

2902600000-乙苯
2902700000-异丙基苯
2905122000-异丙醇
2905310000-1,2-乙二醇
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供应商参考报价(招募中)

品牌试剂参考报价(招募中)

实用工具

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✅ COA系统入驻 | 共享模式

主要参考文献

参考标题:Method For The Synthesis Of Irinotecan
摘要:The Present Invention Relates To A Method For The Synthesis Of 7-Ethyl-10-[4-(1-Piperidino)-1-Piperidino]Carbonyloxy-Camptothecin (I.E. Iriniotecan), Comprising: (A) Preparing 10-[4-(1-Piperidino)-1-Piperidino]Carbonyloxycamptotecin; And (B) Selectively Ethylating The Compound Of Step (A) At The 7-Position, Thus Resulting In The Preparation Of 7-Ethyl-10-[4-(1-Piperidino)-1-Piperidino]Carbonyloxy-Camptothecin. The Present Invention Is Further Directed To A Method For The Synthesis Of 10-[4-(1-Piperidino)-1-Piperidino]Carbonyloxycamptothecin (I.E. 7-Des-Ethyl-Irinotecan) Which Is Used As An Intermediate In The Synthesis Of Irinotecan.