专利号:US-2020308557-A1 优先权日:2017-12-22 标题:Fusion proteins 发明人:MUSSAI FRANCIS JAY; DE SANTO CARMELA; LEE STEVEN 权利人:CANCER RESEARCH TECH LTD 摘要:Provided are fusion target-binding proteins comprising a target binding moiety, an intracellular signalling region and a domain that promotes synthesis of arginine or an arginine precursor. The domain may be an enzyme domain such as an argininosuccinate synthase (ASS-1) enzyme domain, or an ornithine transcarbamylase (OTC) enzyme domain. Also provided are cells comprising such a fusion target-binding protein (for example cells that express the fusion target-binding protein), and nucleic acids encoding such fusion target-binding proteins. The invention also provides fusion target-binding proteins comprising a target binding moiety, an intracellular signalling region and a domain that promotes synthesis of tryptophan or a tryptophan precursor. Pharmaceutical compositions, medical uses, and methods of treatment, all using the fusion target-binding proteins, cells, or nucleic acids are disclosed. The proteins, cells, nucleic acids and pharmaceutical compositions may be used in the prevention and/or treatment of cancer, such as neuroblastoma or acute myeloid leukaemia.
专利号:EP-1099957-A1 优先权日:1998-08-12 标 题:Synthesis of overlapping chirp waveforms
专利号:AU-742977-B2 优先权日:1998-08-12 标 题 :Synthesis of overlapping chirp waveforms
专利号:AU-5932999-A 优先权日:1998-08-12 标题:Synthesis of overlapping chirp waveforms
专利号:CA-2288472-C 优先权日:1998-08-12 标 题:Synthesis of overlapping chirp waveforms
专利号:US-6988071-B1 优先权日:1999-06-10 标 题:Smart elevator system and method 发明人:GAZDZINSKI ROBERT F 权利人:GAZDZINSKI ROBERT F 摘要:An information and control system for personnel transport devices. In one embodiment, the information and control system is coupled to the elevator system of a building, and includes a touch panel input device, a flat panel display having a touch sensitive screen, and speech recognition and synthesis systems serving each elevator car. The speech recognition and synthesis systems and input device(s) are operatively coupled to a processor and storage devices having a plurality of different types of data stored thereon. Each elevator car is also a client connected to a LAN, WAN, intranet, or Internet, and capable of exchanging data with and retrieving data therefrom. Functions performed by the information and control system include a voice-actuated building directory, download of selected data to personal electronic devices (PEDs), monitoring of areas adjacent to the elevator car on destination floors, and control of lighting and security monitoring in selectable areas of destination floors. The system is also optionally fitted with an RFID interrogator/reader capable of recognizing RFID tags carried by passengers on the elevator, thereby granting access to various controlled locations automatically after password authentication. The RFID system also allows the authenticated passenger(s) to control utilities such as lighting and HVAC within specific zones on their destination floors. The information and control system is also optionally equipped with an occupancy estimating sub-system which allows elevator cars to bypass calling floors when their capacity is reached or exceeded.
1: Höbel M, Bender G. Separation and quantitative determination of acecarbromal, carbromal, and bromisoval as well as their main metabolites by means of high-pressure liquid chromatographic analysis. Arch Toxicol. 1977 Aug 9;37(4):307-12. German.
合成参考文献
摘要:Psychotropic Drugs and Related Compounds, 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972, -(423), 1972