CAS: 767-69-1; 6-Bromo-7H-Purine

相似化合物

408328-12-1 2732786-60-4 1146697-80-4

次黄嘌呤置于三溴氧磷体系中,用 乙腈 作为反应溶剂,化学反应 4.0H,以68.4%的收率获得产物6-溴嘌呤
参考文献:一种6‑溴嘌呤的合成方法
标题:一种6‑溴嘌呤的合成方法
摘要:本发明公开了一种6‑溴嘌呤的合成方法,所述方法以次黄嘌呤与三溴氧磷为原料,在有机溶剂与季铵盐的作用下加热回流,反应完成后,真空抽滤除去液体得到6‑溴嘌呤.本发明的合成方法减少了三溴氧磷的使用量,降低了反应温度,缩短了反应时间,降低了6‑溴嘌呤的生产成本.

专利信息

专利号:US-2009318476-A1
优先权日:2006-08-09
标 题 :Azacycloalkane Derivatives as Inhibitors of Stearoyl-Coenzyme a Delta-9 Desaturase
发明人：RAMTOHUL YEEMAM K
权利人:MERCK FROSST CANADA LTD
摘要:Azacycloalkane derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis. Formula (I).

专利号:US-2008032288-A1
优先权日:2004-03-26
标题:Labeling Reagents, Methods for the Synthesis of Such Reagents and Methods for the Detection of Biological Molecules

专利号:US-5576427-A
优先权日:1993-03-30
标 题 :Acyclic nucleoside analogs and oligonucleotide sequences containing them
发明人：COOK PHILIP D; DELECKI DANIEL J; GUINOSSO CHARLES
权利人:STERLING WINTHROP INC
摘要:Compounds of formula I; I wherein R1 is hydrogen, or a blocking group that is compatible with oligonucleotide synthesis; R2 is hydrogen, nitro, lower alkyl amino, diloweralkyl amino or methyl; R3 is hydrogen or -P(R4)OR5; R4 is chlorine, 4-nitroimidazole, imidazole, tetrazole, triazole or di(lower-alkyl)amino-; R5 is methyl, 2-cyanoethyl or 2,2,2-trichloroethyl; n is from 0 to 2 X is oxygen, sulfur, or -NR6; R6 is hydrogen or lower alkyl; Q is chosen from the group consisting of and R7 is lower-alkyl or loweralkyloxy methylene; and R8 is hydrogen, benzoyl, anisoyl, or lower-alkyl carbonyl and its pharmaceutically acceptable addition salts are nucleotide analogs. Modified oligonucleotides containing the nucleoside analogs of formula I are stable to nuclease degradation and are useful in inhibiting gene expression, in sequencing, and in mutagenesis.