CAS: 7241-98-7; Aflatoxin G2

该化合物是一种属于二氟诺古马林级的甲状腺毒素,在结构上类似于亚弗罗波罗毒素 B2, 但其环球开球环则具有显著的区别. 黄曲霉毒素 G2 具有潜在的致癌性,并存在于诸如坚果,谷物和香料等受污染的食物商品中,因此对分析化学和毒理具有重大兴趣. 检测和量化对食品安全评估至关重要,需要高纯度标准,才能用作染色学和免疫学方面的参考材料. 妥善处理和储存由于其轻微的敏感性和稳定性,至关重要.

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CAS号1165-39-5 黄曲霉毒素G1

合成工艺路线路线简述

    📜黄曲霉素 G1置于盐酸,Sodium Hydroxide,乳酸体系中,化学反应生成 黄曲霉素g2
    参考文献:乳酸还原黄曲霉毒素的动力学和机理研究.
    标题:乳酸还原黄曲霉毒素的动力学和机理研究.
    摘要:已研究了在稀酸性水溶液(ph 3.35-4.50)中乳酸对afb(1)还原为afb(2)和afg(1)还原为afg(2)的动力学随乳酸浓度的变化,Afb(1),Afg(1)和37oc的氢离子.发现反应速率相对于乳酸和黄曲霉毒素的浓度为一阶,并且与氢离子浓度无关.用涉及初始形成的瞬态氧鎓中间体的机理解释了实验结果,该中间体倾向于极化烯烃(c = C)碳,这反过来导致速率确定步骤中从乳酸的α-碳原子提取氢化物.
    DOI:10.1016/s0960-894X(02)00533-4

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    专利信息


    专利号:US-2025147014-A1
    优先权日:2022-02-14
    标题:Plasmon-enhanced fluorescence biochemical sensors
    发明人:PINCHUK ANATOLI; SERGEYEVA TETYANA; YARYNKA DARIA; CHEGEL VLADIMIR; LOPATYNSKYI ANDRI
    权利人:UNIV COLORADO REGENTS; THE REGENTS OF THE UNIV OF COLORADO A BODY
    摘要:A highly sensitive technology enabling selective recognition of aflatoxins such as in contaminated cereal samples. Methods for the synthesis of AgNP-containing MIP membranes from the monomer mixtures containing both methacrylate monomers and oligomers as well as AgNOs solution in dimethylformamide enable the detection system. The AgNP were formed in the structure of the polymeric membranes during the pre-heating step followed by the UV-initiated polymerization. The highly selective sensor elements where MIP membranes are combined with the Ag nanostructures as signal amplifiers (LSPR-MIP nanochips) can be stored separately and used with a simple optical recognition system as selective elements of point-of-care sensor devices, even in in-field conditions. Composite plasmonic membranes provide both highly selective recognition of the target toxin and the generation of an enhanced optical signal, allowing aflatoxin B1 detection at ultralow concentrations.

    专利号:CN-113307302-A
    优先权日:2021-07-09
    标题 :A method for the controllable morphology-controlled synthesis of highly loaded zinc oxide nanomaterials for mycotoxins

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    主要参考文献


    1: Tessema M, De Groote H, Brouwer ID, De Boevre M, Vidal A, Stoecker BJ, Feskens EJM, Belachew T, Karakitsou A, Gunaratna NS. Exposure to aflatoxins and fumonisins and linear growth of children in rural Ethiopia: a longitudinal study. Public Health Nutr. 2021 Feb
    1:1-28. doi: 10.1017/S1368980021000422. Epub ahead of print.
    11:1916. doi: 10.3389/fmicb.2020.01916.

    合成参考文献


    摘要:Tabata S et al; J AOAC Internatl 76: 32-5 (1993)
    摘要:Full text:
    摘要:US EPA; Estimation Program Interface (EPI) Suite. Ver. 4.1. Nov, 2012. Available from, as of Jun 19, 2013:
    摘要:Franke C et al; Chemosphere 29: 1501-14 (1994)
    摘要:L1879: Aflatoxins: essential data http://www.cbwinfo.com/Biological/Toxins/aflatoxins.html
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