CAS: 65-82-7; Ac-Met-Oh

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CAS号60-35-5 乙酰胺 | CAS号3268-49-3 3-甲硫基丙醛 | CAS号201230-82-2 carbon monoxide | CAS号79-20-9 乙酸甲酯 | CAS号59-51-8 DL-蛋氨酸 | CAS号63-68-3 L-蛋氨酸 | CAS号108-24-7 乙酸酐 | CAS号74-93-1 甲硫醇 | CAS号51524-71-1 乙酰基-L-高丝氨酸内酯 | CAS号17351-39-2 N-acetyl-Met-Ala | CAS号35671-83-1 N-乙酰-L-蛋氨酸甲酯 | CAS号63-68-3 L-蛋氨酸 | CAS号1115-47-5 N-乙酰-DL-蛋氨酸

N-Acetylated L-Methionylglycine置于c14H36N6O2Pt2(4+),水体系中,化学反应 24.0H,反应生成 N-乙酰-L-蛋氨酸
参考文献:各种吡嗪桥联的铂(II)配合物的合成,光谱和x射线表征:1 H NMR比较研究其催化甲硫氨酸和组氨酸二肽水解的能力
标题:各种吡嗪桥联的铂(II)配合物的合成,光谱和x射线表征:1 H NMR比较研究其催化甲硫氨酸和组氨酸二肽水解的能力
摘要:摘要四种吡嗪(pz)桥连的pt(II)配合物[{pt(1,3-Pd)cl} 2(μ-Pz)] Cl 2.licl(1)(1,3-Pd = 1,3-丙二胺),[{pt(2,2-Dime-1,3-Pd)cl} 2(μ-Pz)] Cl 2.2 [li(H2O)4] Cl.2H2O(2) (2,2-Dime-1,3-Pd = 2,2-二甲基-1,3-丙二胺),[{pt(1,3-Pnd)cl} 2(μ-Pz)](clo 4)2 .H2O(3)(1,3-Pnd =(+/-)-1,3-戊二胺)和[{pt(1,3-Pnd)cl} 2(μ-Pz)] Cl 2.2 [pt合成了(1,3-Pnd)cl 2].2H2O(4).已经对化合物1-3进行了NMR和uv-Vis光谱表征,对配合物2和4进行了单晶x射线分析.4晶体中的原子分布表明存在一种无序现象,这可能归因于[{pt(1,3-Pnd)cl} 2(μ-Pz)]
DOI:10.1016/j.Poly.2016.06.011

专利信息

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:US-2006287520-A1
优先权日:2005-05-16
标 题 :Synthesis of salinosporamide A and analogues thereof
发明人：DANISHEFSKY SAMUEL J; ENDO ATSUSHI
权利人:DANISHEFSKY SAMUEL J; ENDO ATSUSHI
摘要:A novel synthesis of salinosporamide A is provided. Salinospoamide A as well as structurally related natural products, omuralide and lactacystin, have been shown to be proteasome inhibitors. Therefore, these compounds as well as analogues of these natural products may be useful in the treatment of proliferative diseases such as cancer, autoimmune diseases, diabetic retinopathy, etc. The invention provides for the synthesis of salinosporamide A as well as analogs thereof using a convenient point for derivatization of the bicyclic core. Pharmaceutical compositions and method of using the inventive compounds are also provided.

专利号:US-7910623-B2
优先权日:2005-07-22
标 题 :Synthesis of scabronines and analogues thereof
发明人：DANISHEFSKY SAMUEL J; WATERS STEPHEN P
权利人:SLOAN KETTERING INST CANCER
摘要:A novel synthesis of scabronines, which are related to a broader class of angularly fused tricyclic diterpenoids known as cyathanes, is provided. Scabronine G, its methyl ester derivative, and other analogs have been shown to have neurotrophic activity. Therefore, these compounds are particularly useful in treating neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's diseases, etc. The invention provides for the synthesis of scabronines as well as analogs thereof. Pharmaceutical compositions and method of using the inventive compounds are also provided.

专利号:WO-2012047907-A9
优先权日:2010-10-04
标题 :Synthesis of c5-substituted tetracyclines, uses thereof, and intermediates thereto
发明人：MYERS ANDREW G; WRIGHT PETER M; HECKER EVAN
权利人:HARVARD COLLEGE; MYERS ANDREW G; WRIGHT PETER M; HECKER EVAN
摘要:The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. The present invention provides more efficient routes for preparing the enone intermediate and allows for a wide variety of substituents at position 5 of the tetracycline ring system.

专利号:US-11220513-B2
优先权日:2015-04-30
标题:Chromium-mediated coupling and application to the synthesis of halichondrins
发明人：KISHI YOSHITO; YAN WUMING; LI JINGWEI; LI ZHANJIE; YAHATA KENZO
权利人:HARVARD COLLEGE
摘要:The present invention provides unified synthesis of the C1-C19 building blocks of halichondrins and analogs thereof using selective coupling of poly-halogenated nucleophiles in chromium-mediated coupling reactions. The present invention also provides a practical and efficient synthesis of C20-C38 building blocks of halichondrins and analogs thereof. Also provided herein are general methods of selective activation and coupling of poly-halogenated analogs with an aldehyde. The provided coupling reactions are selective for halo-enone and halo-acetylenic ketal over vinyl halide and halide attached to a sp hybridized carbon. The provided efficient selective coupling reactions can allow easy access to the C1-C19 building blocks and C20-C38 building blocks of halichondrins and analogs thereof with limited or no purification or separation of the intermediates.

专利号:US-9688644-B2
优先权日:2009-04-30
标 题 :Synthesis of Tetracyclines and intermediates thereto
发明人：MYERS ANDREW G; KUMMER DAVID A; LI DERUN; HECKER EVAN; DION AMELIE; WRIGHT PETER M
权利人:HARVARD COLLEGE
摘要:The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. The present invention provides more efficient routes for preparing the enone intermediate and allows for substituents at positions 4a, 5, 5a, and 12a of the tetracycline ring system.