CAS: 578-58-5; 1-Methoxy-2-Methylbenzene

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CAS号612-16-8 2-甲氧基苯甲醇 | CAS号95-48-7 邻甲酚 | CAS号77-78-1 硫酸二甲酯 | CAS号823-96-1 三甲基环三硼氧烷 | CAS号766-51-8 邻氯苯甲醚 | CAS号529-28-2 邻碘苯甲醚 | CAS号74-88-4 碘甲烷 | CAS号578-57-4 邻溴苯甲醚 | CAS号544-97-8 二甲基锌 | CAS号137203-34-0 DABAL-三甲基铝 | CAS号4223-84-1 1-(2-羟基-5-甲氧基-4... | CAS号41295-28-7 甲氧苯酮 | CAS号576-55-6 3,4,5,6-四溴邻甲酚 | CAS号50741-92-9 2-甲氧基-5-硝基苯甲醚 | CAS号18102-29-9 2-甲基-6-硝基苯甲醚 | CAS号108088-85-3 2-methyl-4-(tri... | CAS号82280-91-9 2,3'-dinitro-4,... | CAS号534-52-1 4,6-二硝基邻甲酚 | CAS号42298-41-9 5-碘-2-甲氧基苯甲醛 | CAS号95-87-4 2,5-二甲基苯酚

邻甲氧基苯乙腈置于15-冠醚-5,Sodium,水体系中,用 四氢呋喃,正己烷 作为反应溶剂,化学反应 1.33H,以98%的收率获得产物2-甲基苯甲醚
参考文献:无氨桦木条件下未活化的碳-氰基键的还原裂解.
标题:无氨桦木条件下未活化的碳-氰基键的还原裂解.
摘要:在单电子转移条件下,使用na / 15-Crown-5 / H2O,已实现了脂族腈中未活化的碳-氰基键的还原性裂解的通用方案.电子由稳定的钠分散液和可回收的15-Cro-5衍生的驻极体提供.H2O提供质子源并抑制芳族部分的还原.与在传统的桦木条件下反应生成的na / Nh3驻极体系统相比,这种无氨的驻极体系统更实用,并且对于多种脂族腈的脱氰反应具有更好的反应性和化学选择性.
DOI:10.1021/acs.Joc.9B02028

专利信息

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:WO-9312076-A1
优先权日:1991-12-13
标题:Reagents for automated synthesis of peptide analogs
发明人：WEBB THOMAS ROY
权利人:CORVAS INT INC
摘要:Reagents suitable for synthesis of peptide analogs using automated peptide synthesis and procedures for synthesis of peptide analogs are provided.

专利号:WO-2012047907-A9
优先权日:2010-10-04
标题 :Synthesis of c5-substituted tetracyclines, uses thereof, and intermediates thereto
发明人：MYERS ANDREW G; WRIGHT PETER M; HECKER EVAN
权利人:HARVARD COLLEGE; MYERS ANDREW G; WRIGHT PETER M; HECKER EVAN
摘要:The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. The present invention provides more efficient routes for preparing the enone intermediate and allows for a wide variety of substituents at position 5 of the tetracycline ring system.

专利号:WO-0058264-A1
优先权日:1999-03-26
标 题:Method for the synthesis of non-symmetrical dtpa compounds
发明人：ACHILEFU SAMUEL I; SRINIVASAN ANANTHACHARI
权利人:MALLINCKRODT INC; ACHILEFU SAMUEL I; SRINIVASAN ANANTHACHARI
摘要:The synthesis of compounds of formula (XIV) wherein each R4 is an alkyl group having 1 to 15 carbon atoms, and R6 is a linking moiety having 1 to 10 carbon atoms, is disclosed. These compounds are useful intermediates in the synthesis of compounds of formula (X). These compounds are useful in the preparation of nuclear pharmaceuticals such as those used for tumor imaging or tumor therapy.

专利号:WO-0140193-A1
优先权日:1999-12-03
标题:Method for the synthesis of pyrazolines
发明人：BOLDI ARMEN M
权利人:CHEMRX ADVANCED TECHNOLOGIES I; BOLDI ARMEN M
摘要:The present invention provides a method for the synthesis of compounds of Formula (I). Also claimed are novel intermediates and their methods of synthesis.

专利号:US-2002103381-A1
优先权日:2000-11-30
标 题 :Method for the synthesis of pyrazolines
发明人：BOLDI ARMEN M
摘要:The present invention provides a method for the synthesis of compounds of Formula I: n n n Also claimed are novel intermediates and their methods of synthesis.