CAS: 5407-87-4; 2-Amino-4,6-Dimethylpyridine

该化合物是三环有机化合物,在2个位置和4个和6个位置的甲状腺组和甲基组中以氨基氨基中以芯替换.这种结构具有独特的反应性,使其成为制药和农用化学合成中有价值的中间体.其富电芳香系统和核生殖性氨基组促进了选择性功能化,使得在离子体设计和催化中能够应用.该化合物的稳定性和明确界定的晶体形式确保合成工作流程的一致性能.它对于制作基于的复合体和作为生物活性分子的建筑块特别有用.建议在对空气和湿度的敏感度下妥善处理.

结构式图片

相似化合物

1824-81-3 1805960-63-7 848472-36-6

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

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合成工艺路线路线简述

    2,4-二甲基吡啶置于sodium Amide,Xylene体系中,化学反应生成 2-氨基-4,6-二甲基吡啶
    参考文献:Lecocq,Bulletin De La Societe Chimique De France,1950,P. 188,190
    标题:Lecocq,Bulletin De La Societe Chimique De France,1950,P. 188,190

    海关参考信息

    专利信息


    专利号:US-9758507-B2
    优先权日:2010-07-01
    标 题:Chiral synthesis of pyrrolidine core compounds en route to neuronal nitric oxide synthase inhibitors
    发明人:SILVERMAN RICHARD B; XUE FENGTIAN
    权利人:UNIV NORTHWESTERN
    摘要:A chiral synthesis of pyrrolidine compounds en route to selective neuronal nitric oxide synthase inhibitors, and representative inhibitor compounds heretofore unattainable.

    专利号:US-5424432-A
    优先权日:1994-05-26
    标题:Process for the preparation of imidazolutidine
    发明人:FREDENBURGH LAURA E; LARSEN ROBERT D; LIU JI; REAMER ROBERT A; SENANAYAKE CHRIS H; VERHOEVEN THOMAS R
    权利人:MERCK & CO INC
    摘要:This invention relates to a method for the preparation of a compound of formula I: I a key intermediate in the synthesis of a series of Angiotensin II receptor antagonists. The invention also relates to a selective reagent for conducting the Hofmann rearrangement, particularly in the formation of a pyridinoimidazolone, which is a percursor to the formation of an imidazopyfidine of formula I. This invention also relates to a method for the preparation of imidazolutidine, a key intermediate in the synthesis of 3-(2'-(N-benzoyl)sulfonamidobiphen-4-yl)-methyl-5,7 -dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridine, using pyridinoimidazolone, an unreactive urea.

    专利号:US-8729257-B2
    优先权日:2009-07-17
    标题 :Hybrid lipid compounds based on pentaerythritol, intermediates, preparation methods and use thereof
    发明人:DAI ZHIFEI; LIANG XIAOLONG; YUE XIULI
    权利人:DAI ZHIFEI; LIANG XIAOLONG; YUE XIULI; HARBIN INST OF TECHNOLOGY
    摘要:This invention relates to a novel class of hybrid lipid compound based on pentaerythritol, their intermediates, preparation methods and uses thereof. Different kinds of functional groups such as alkyl chain, siloxane group, azobenzene, porphyrins, cholesterol, benzene ring and carboxyl were introduced into the four hydroxyl groups of pentaerythritol through chemical reaction to obtain the final hybrid lipid compounds based on pentaerythritol. Cerasomes prepared from such lipids have uniform size, silicate network surface, good stability and biocompatibility, and the leakage of drugs is not easy. The present liposome can be used as functional materials such as drugs or drug carriers, or used for optical storage and molecular devices, simulation, design and synthesis of artificial systems, nano-composite membrane materials and the removal of organic pollutants, etc., in addition, the preparation method of the present invention is simple, and it is easy for industrial production.

    专利号:US-6531470-B1
    优先权日:1998-01-23
    标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
    发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
    权利人:UPJOHN CO
    摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

    专利号:US-5880294-A
    优先权日:1996-05-16
    标 题 :D-pentofuranose derivatives and process for preparing the same
    发明人:NOMURA MAKOTO; KAZUNO HIDEKI; SATO TSUTOMU; WASHINOSU MASATO; TANAKA MOTOAKI; MATSUDA AKIRA; ASAO TETSUJI
    权利人:TAIHO PHARMACEUTICAL CO LTD
    摘要:The present invention relates to D-pentofuranose derivatives represented by the following formulas (1) through (4): ##STR1## (wherein A represents a chlorobenzoyl group; R 1 represents a hydrogen atom, an aliphatic lower acyl group, a substituted or unsubstituted benzoyl group; each of X and Y represents a lower alkyl group; Z represents an ethynyl group or tri-lower alkyl silylethynyl group; the sugar moiety in formula (1) represents xylose; and the sugar moiety of each of formulas (3) and (4) represents ribose). The present invention also relates to a process for preparing the compound (2) characterized by oxidizing the compound of formula (1) with a hypochlorite in the presence of a catalytic amount of 2,2,6,6-tetramethylpiperidinoxy compound, and these compounds are useful as intermediates in the synthesis of 3'-C-substituted ribonucleoside derivatives having excellent antitumor activities.

    专利号:US-5290797-A
    优先权日:1991-03-08
    标 题:Benzopyran compounds
    发明人:LE BAUT GUILLAUME; BABINGUI JEAN-PAUL; ROBERT JEAN-MICHEL; RENARD PIERRE; RENAUD DE LA FAVERIE JEAN-FRAN; ADAM GERARD
    权利人:ADIR
    摘要:A compound selected from those of the formula I: I in which: R1 represents hydrogen or alkyl having 1 to 3 inclusive carbon atoms, R represents hydrogen, alkyl having 1 to 4 inclusive carbon atoms, or acyl -CO-R' in which R' represents alkyl having 1 to 4 inclusive carbon atoms, X represents O or H2, an isomer, and an addition salt thereof with a pharmaceutically-acceptable acid or base, and medicinal products containing the same which are useful in treating or in preventing disorder resulting from or associated with phenomena of peroxidation and disturbance of the synthesis of eicosanoids.
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    合成参考文献


    摘要:Schafer, E. W., Jr., and W. A. Bowles Jr. 1985. Acute oral toxicity and repellency of 933 chemicals to house and deer mice. Archives of Environmental Contamination and Toxicology 14:111-129.
    参考文献:10.1107/s1600536810034811
    摘要:Asaruddin MR, Wahab HA, Mohamed N, Rosli MM, Fun HK. 2-Amino-4,6-dimethyl-pyridinium benzoate. Acta Crystallogr Sect E Struct Rep Online. 2010 Sep 04;66(Pt 10):o2496.
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