CAS: 5323-57-9; Quinoline-2,4-Dicarboxylic Acid

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60506-24-3 7170-24-3 7170-27-6

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📜Alpha-酮戊二酸置于氯化亚砜,2-甲基苯磺酸,Hydroxide,溴体系中,用 四氢呋喃,二氯甲烷 作为反应溶剂,化学反应 27.5H,反应生成 喹啉-2,4-二羧酸
参考文献:Synthesis And In Vitro Pharmacology Of Substituted Quinoline-2,4-Dicarboxylic Acids As Inhibitors Of Vesicular Glutamate Transport
标题:Synthesis And In Vitro Pharmacology Of Substituted Quinoline-2,4-Dicarboxylic Acids As Inhibitors Of Vesicular Glutamate Transport
摘要:The Vesicular Glutamate Transport (Vglut) System Selectively Mediates The Uptake Of L-Glutamate Into Synaptic Vesicles. Uptake Is Linked To An H+-Atpase That Provides Coupling Among Atp Hydrolysis,An Electrochemical Proton Gradient,And Glutamate Transport. Substituted Quinoline-2,4-Dicarboxylic Acids (Qdcs),Prepared By Condensation Of Dimethyl Keto-Glutaconate (Dkg) With Substituted Anilines And Subsequent Hydrolysis,Were Investigated As Potential Vglut Inhibitors In Synaptic Vesicles. A Brief Panel Of Substituted Qdcs Was Previously Reported (Carrigan Et Al. Bioorg. Med. Chem. Lett. 1999,9,2607-2612),And Showed That Certain Substituents Led To More Potent Competitive Inhibitors Of Vglut. Using These Compounds As Leads,An Expanded Series Of Qdc Analogues Were Prepared Either By Condensation Of Dkg With Novel Anilines Or Via Aryl-Coupling (Suzuki Or Heck) To Dimethyl 6-Bromoquino-Linedicarboxylate. From The Panel Of Almost 50 Substituted Qdcs Tested As Inhibitors Of The Vglut System,The 6-Phch=ch-Qdc (K-I = 167 Mum),6-Phch2Ch2-Qdc (K-I = 143 Mum),6-(4'-Phenylstyryl)-Qdc (K-I = 64 Am),And 6-Biphenyl-4-Yl-Qdc (K-I = 41 Mum) Were Found To Be The Most Potent Blockers. A Preliminary Assessment Of The Key Elements Needed For Binding To The Vglut Protein Based On The Structure-Activity Relationships For The Panel Of Substituted Qdcs Is Discussed Herein. The Substituted Qdcs Represent The First Synthetically Derived Vglut Inhibitors And Are Promising Templates For The Development Of Selective Transporter Inhibitors.
DOI:10.1021/jm010261Z

专利信息

专利号:US-12263464-B2
优先权日:2018-03-14
标题 :Method for in-situ synthesis of metal organic frameworks (MOFs), covalent organic frameworks (COFs) and zeolite imidazolate frameworks (ZIFs), and applications thereof
发明人：PAHWA DEEPAK; PAHWA VARUN; CHOUDHARY ANIL KUMAR; SONIA; JHA VIVEK KUMAR; CHAUHAN ANJALI; YADAV ANNU
权利人:DESICCANT ROTORS INTERNATIONAL PRIVATE LTD
摘要:The present invention relates to a method for the in situ synthesis of of MOFs (metal organic frameworks), COFs (covalent organic frameworks), and ZIFs (Zeolitic imidazolate framework), onto and within different types of porous substrates, and their applications. The present invention provides a unique and easy to utilize method by which a number of MOFs, COFs and ZIFs can be synthesized directly onto and within a porous substrate with high performance efficiency ensuring higher grammage in formation of adsorbent product onto and within the substrate.

专利号:US-2022089618-A1
优先权日:2019-01-29
标题:Solid-State Synthesis Of Precursors Of Metal-Organic Frameworks
发明人：MAJANO GERARDO J; FALKOWSKI JOSEPH M
权利人:EXXONMOBIL RES & ENG CO
摘要:Metal-organic frameworks (MOFs) are highly porous entities comprising a multidentate ligand coordinated to multiple metal atoms, typically as a coordination polymer. MOFs are usually produced from a solvent in powder form under hydrothermal or solvothermal synthesis conditions. Alternately, powder-form precursors of MOFs may be formed by milling or mulling a substantially solid mixture of a metal salt and a multidentate organic ligand, optionally in the presence of a small amount of a solvent. The powder-form precursors may then undergo heating, typically in the absence of applied shear, to produce the corresponding MOF. Mulling may be differentiated from milling at least in that mulling applies to the substantially solid mixture at a non-constant pressure and milling applies a constant pressure while forming the powder-form precursor. In some cases, mulling may promote more effective formation of the powder-form precursor compared to milling.

专利号:US-10737239-B2
优先权日:2015-11-27
标题 :Ultrafast high space-time-yield synthesis of metal-organic frameworks
发明人：BURCKHART JULIA; MARX STEFAN; ARNOLD LENA; HOFMANN CLAUS; Müller Ulrich
权利人:BASF SE
摘要:The invention relates to a process for the preparation of metal-organic frameworks (MOFs) in form of a homogenous powder, and a process wherein the metal-organic framework is molded into shaped bodies.

专利号:US-9951095-B2
优先权日:2014-05-16
标 题:Chromium metal organic frameworks and synthesis of metal organic frameworks
发明人：ZHOU HONG-CAI; Liu tian-fu; LIAN XIZHEN; ZOU LANFANG; FENG DAWEI
权利人:TEXAS A & M UNIV SYS
摘要:The present invention relates to monocrystalline metal organic frameworks comprising chromium ions and carboxylate ligands and the use of the same, for example their use for storing a gas. The invention also relates to methods for preparing metal organic frameworks comprising chromium, titanium or iron ions and carboxylate ligands. The methods of the invention allow such metal organic frameworks to be prepared in monocrystalline or polycrystalline forms.

专利号:US-11891406-B2
优先权日:2019-03-14
标题:Conductivity enhancement of MOFs via development of MOFpolymer composite material
发明人：PEEDIKAKKAL ABDUL MALIK P; AL-BETAR ABDUL-RAHMAN; AL-MOUSA AMMAR HUSSAIN
权利人:UNIV KING FAHD PET & MINERALS
摘要:A method for enhancing the conductivity of MOF-5 by the development of an MOF-5 polymer composite material. The composite material incorporates a conductive polymer, preferably polyaniline, in the solvo-thermal synthesis pathway of MOF-5. The electrically conductive MOF-5 composite exhibits electric conductivity three orders of magnitude higher than that of MOF-5 while maintaining the crystallinity, robustness, and thermal stability of MOF-5.

专利号:US-2018333696-A1
优先权日:2015-11-27
标题:Ultrafast high space-time-yield synthesis of metal-organic frameworks