专利号:US-5525325-A 优先权日:1989-03-06 标 题 :Expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles 发明人:SESSLER JONATHAN L; HEMMI GREGORY W; MURAI TOSHIAKI 权利人:REGENTS UNIVERSITY OF TEXAS BO 摘要:The present invention involves a novel tripyrrole dimethine-derived 'expanded porphyrin' (texaphyrin), the synthesis of such compounds, their analogs or derivatives and their uses. These expanded porphyrin-like macrocycles are efficient chelators of divalent and trivalent metal ions. Metal complexes of these compounds are active as photosensitizers for the generation of singlet oxygen and thus potentially for inactivation or destruction of human immunodeficiency virus (HIV-1), mononuclear or other cells infected with such virus and tumor cells as well. A variety of texaphyrin derivatives have been produced and many more are readily obtainable. Various metal (e.g., transition, main group, and lanthanide) complexes with the texaphyrin and texaphyrin derivatives of the present invention have unusual water solubility and stability which render them particularly useful. These metallotexaphyrin complexes have optical properties making them unique as compared to existing porphyrin-like or other macrocycles. For example, they absorb light strongly in a physiologically important region (i.e. 690-880 nm). These complexes also form long-lived triplet states in high yield and act as efficient photosensitizers for the formation of singlet oxygen. These properties, coupled with their high chemical stability and appreciable solubility in polar media such as water, add to their usefulness.
专利号:US-8871926-B1 优先权日:2010-09-28 标题:Synthesis of porphyrin nanostructures 发明人:FAN HONGYOU; BAI FENG 权利人:FAN HONGYOU; BAI FENG; SANDIA CORP 摘要:The present disclosure generally relates to self-assembly methods for generating porphyrin nanostructures. For example, in one embodiment a method is provided that includes preparing a porphyrin solution and a surfactant solution. The porphyrin solution is then mixed with the surfactant solution at a concentration sufficient for confinement of the porphyrin molecules by the surfactant molecules. In some embodiments, the concentration of the surfactant is at or above its critical micelle concentration (CMC), which allows the surfactant to template the growth of the nanostructure over time. The size and morphology of the nanostructures may be affected by the type of porphyrin molecules used, the type of surfactant used, the concentration of the porphyrin and surfactant the pH of the mixture of the solutions, and the order of adding the reagents to the mixture, to name a few variables.
专利号:US-2005250765-A1 优先权日:2000-08-16 标题 :Diazepinones as antiviral agents 发明人:CHO HIDETSURA; GOGLIOTTI ROCCO D; HAMILTON HARRIET W; KRASUTSKY ALEXEI; NAKAMURA TAKESHI; TADA HIROKI; WEBER PETER C 权利人:CHO HIDETSURA; GOGLIOTTI ROCCO D; HAMILTON HARRIET W; KRASUTSKY ALEXEI; NAKAMURA TAKESHI; TADA HIROKI; WEBER PETER C 摘要:The invention is novel compounds of formula n nwhich exhibit an improved therapeutic index and improved metabolic stability which are useful in the treatment and/or prevention of herpes viral infections. Novel intermediates useful in the synthesis of the final compounds are also part of the invention.
专利号:US-5256399-A 优先权日:1989-03-06 标题:Aromatic pentadentate expanded porphyrins in magnetic resonance imaging 发明人:SESSLER JONATHAN L; HEMMI GREGORY W; MURAI TOSHIAKI 权利人:UNIV TEXAS 摘要:The present invention involves a novel tripyrrole dimethine-derived 'expanded porphyrin' (texaphyrin), the synthesis of such compounds, their analogs or derivatives and their uses. These expanded porphyrin-like macrocycles are efficient chelators of divalent and trivalent metal ions. Metal complexes of these compounds are active as photosensitizers for the generation of singlet oxygen and thus potentially for inactivation or destruction of human immunodeficiency virus (HIV-1), mononuclear or other cells infected with such virus and tumor cells as well. A variety of texaphyrin derivatives have been produced and many more are readily obtainable. Various metal (e.g., transition, main group, and lanthanide) complexes with the texaphyrin and texaphyrin derivatives of the present invention have unusual water solubility and stability which render them particularly useful. These metallotexaphyrin complexes have optical properties making them unique as compared to existing porphyrin-like or other macrocycles. For example, they absorb light strongly in a physiol n This invention was made in part with government support under the National Science Foundation Presidential Young Investigator Award (1986) to J. L. Sessler, grant CHE-8552768. The government has certain rights in the invention.
专利号:CN-112028900-A 优先权日:2020-09-10 标 题:Synthesis of Star-shaped Polymers and Unimolecular Micelles by Photo-Controlled In-situ Bromine-Iodine Conversion RDRP Method
专利号:US-5587463-A 优先权日:1989-03-06 标 题 :Texaphyrin macrocycles and metal complexes thereof 发明人:SESSLER JONATHAN L; HEMMI GREGORY W; MURAI TOSHIAKI 权利人:UNIV TEXAS 摘要:The present invention involves a novel tripyrrole dimethine-derived 'expanded porphyrin' (texaphyrin), the synthesis of such compounds, their analogs or derivatives and their uses. These expanded porphyrin-like macrocycles are efficient chelators of divalent and trivalent metal ions. Metal complexes of these compounds are active as photosensitizers for the generation of singlet oxygen and thus potentially for inactivation or destruction of human immunodeficiency virus (HIV-1), mononuclear or other cells infected with such virus and tumor cells as well. A variety of texaphyrin derivatives have been produced and many more are readily obtainable. Various metal (e.g., transition, main group, and lanthanide) complexes with the texaphyrin and texaphyrin derivatives of the present invention have unusual water solubility and stability which render them particularly useful. These metallotexaphyrin complexes have optical properties making them unique as compared to existing porphyrin-like or other macrocycles. For example, they absorb light strongly in a physiologically important region (i.e. 690-880 nm). These complexes also form long-lived triplet states in high yield and act as efficient photosensitizers for the formation of singlet oxygen. These properties, coupled with their high chemical stability and appreciable solubility in polar media such as water, add to their usefulness.
1.) Berenbaum, M.C., Akande, S.L., Bonnett, R., Kaur, H., Ioannou, S., White, R.D., Winfield, U.J.; Meso-Tetra(hydroxyphenyl)porphyrins, a new class of potent tumor photosensitisers with favorable selectivity. British Journal of Cancer 1986, 54, 717-725. https://doi.org/10.1038/bjc.1986.232 2.) Berenbaum, M.C., Bonnett, R., Chevretton, E.B., Akande-Adebakin, S.L, Ruston, M.; Selectivity of meso-tetra(hydroxyphenyl)porphyrins and chlorins and of photofrin II in causing photodamage in tumour, skin, muscle, and bladder. The concept of cost-benefit in analysing the results. Lasers in Medical Science 1993,8, 235-243. https://doi.org/10.1007/BF02547845 3.) Wikene, K.O., Bruzell, E., Tonnesen, H.H; Improved antibacterial phototoxicity of a neutral porphyrin in natural deep eutectic solvents. Journal of Photochemistry and Photobiology B: Biology 2015, 148, 188-196. https://doi.org/10.1016/j.jphotobiol.2015.04.022 4.) Nicosia, A., Abbadessa, A., Vento, F., Mazzaglia, A., Mineo, P.G.; Silver Nanoparticles Decorated with PEGylated Porphyrins as Potential Theranostic and Sensing Agents. Materials 2021, 14, 2764. https://doi.org/10.3390/ma14112764 5.) Sajjad, M., Lu, W.; Covalent organic frameworks based nanomaterials: Design, synthesis, and current status for supercapacitor applications: A review. Journal of Energy Storage, 2021, 39, 102618. https://doi.org/10.1016/j.est.2021.102618
合成参考文献
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