CAS: 3638-73-1; 2,5-Dibromobenzenamine

该化合物是一种有机化合物,其特点是存在两个溴原子和一个附于苯环的氨基组,其分子式为C6H4BR2N,表明含有六碳原子,四个氢原子,两个溴原子和一个氮原子.该化合物一般在室温时呈现为固体,以其黄色黄色至棕色为名. 2.5-二溴乙烷在有机溶剂中溶解,但由于其水分疏漏芳香结构,其溶解性在水中有限.该分子式主要用于染料,药品和农用化学合成.溴亚化物的存在增强了其再活性,使其在各种化学反应中成为有价值的中间体.此外,它与许多溴化化合物一样,可能对环境和健康造成危害,需要小心地处理和处置.在具体处理准则中,应参考安全数据表,因为吸入或浸泡水时可能会造成伤害,并可能导致皮肤和眼刺激.

⚠️危险化学品目录(2015年版) 急性毒性-经口,类别3
英文名称2,5-Dibromobenzenamine
中文名称2,5-二溴苯胺
IUPAC名称2,5-dibromoaniline
其它别名2,5-Dibromobenzenamine
CAS编号3638-73-1
MFCD编号:MFCD00007636
EINECS号:222-865-5
FDA UNII编号:C54DZ85Z8H
分子式:C6H5Br2N
分子量:250.92
产品CID: 1373156
产品分类有机原料 → 氨基化合物 → 环烷胺、芳香单胺、芳香多胺及其衍生物和盐

相似结构搜索
InChIKey: WRTAZRGRFBCKBU-UHFFFAOYSA-N
InChI=1S/C6H5Br2N/c7-4-1-2-5(8)6(9)3-4/h1-3H,9H2…
计算化学: 氢键受体数1.0氢键供体数1.0可旋转键数0.0

物理性质

熔点51-53 °C(文献)
沸点281.4±20.0 °C at 760 mmHg
闪点124.0±21.8 °C
密度2.0±0.1 g/cm3
pKa:1.46±0.10(预测)
PSA:26.02
LogP:3.38
折射率1.661
蒸汽压0.0±0.6 mmHg at 25°C
溶解性Soluble In Ethanol,Methanol
敏感性常温常压下稳定，黄色棱柱状结晶。易溶于乙醇，溶于乙醚，不溶于水。熔点51～52°C。闪点＞112°C 。有毒。对眼睛、呼吸系统、皮肤有刺激性。
外观形态米色至深灰色结晶粉末
储存条件避光，通风干燥环境处，密封保存保存
产品应用用于有机合成.
性质描述熔点51-52°C,易溶于醇和醚.

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别急性毒性类别4(吸入)
急性毒性类别4(经皮)
急性毒性类别4(经口)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
皮肤致敏类别1
急性毒性类别3(经皮)
严重眼刺激类别2A
警示词Warning(警告)
危险描述H332 |吸入有害.
H312 |皮肤接触有害.
H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H317 |可能引起皮肤过敏反应.
H311 |皮肤接触会中毒.
防范说明P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338
危险等级6.1
UN编号2811
危险品标志Xn,Xi
风险等级Irritant
包装等级III
安全声明26-36-36/37/39
危险类别码20/21/22-36/37/38-33
WGK Germany3

欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

合成工艺路线路线简述

合成目标产物 2,5-Dibromobenzenamine 主要起始原料 2,5-Dibromonitrobenzene
(文献来源)合成步骤主要原料 2,5-Dibromonitrobenzene

2,5-二溴硝基苯置于盐酸,铁粉体系中,用乙醇,水用作溶剂,化学反应 4.0H,以100%的收率获得2,5-二溴苯胺
参考文献:双环苯基-乙炔基结构:1,4-双(苯基丁-1,3-二炔-1-基)苯banister的合成
标题:双环苯基-乙炔基结构:1,4-双(苯基丁-1,3-二炔-1-基)苯banister的合成
摘要:在旋转限制的"geländer"低聚物的背景下,介绍并讨论了新型二乙炔桥连三联苯大环1 .丁二炔1的 1,4-双(苯基丁-1,3-二炔-1-基)苯桥明显长于其三联苯主链,迫使桥绕中心塔弯曲.分子1的合成在很大程度上基于乙炔支架策略,利用正交炔保护基团通过氧化乙炔偶联顺序封闭两个大环亚基.分析了双环目标结构1的空间排列和动态对映过程.深入的核磁共振研究不仅揭示了两条低聚物链沿着主链弯曲的意想不到的空间排列,而且还显示了模型化合物在分子氧存在下的有限稳定性.
Doi:10.1002/chem.202005207

专利信息

专利号:US-6096853-A
优先权日:1998-12-21
标题 :Synthesis of phenolic monomers containing imide or diimide moieties and high heat carbonate polymers prepared therefrom
发明人：AMERIK VALENTINA; HOEKS THEODORUS L; LIKIBI PARFAIT JEAN MARIE; NELSON MARK
权利人:GEN ELECTRIC
摘要:A process has been surprisingly discovered that can produce a high heat carbonate polymer (i.e., one with a Tg greater that 150Â° C.), without the drawbacks encountered in attempts to produce a high heat carbonate polymer. The process of the instant invention comprises the steps of: n (1) reacting an aromatic amine with a dihydric phenol to prepare an aminophenol; n (2) reacting an anhydride or dianhydride with the aminophenol to prepare a phenolic precursor; and n (3) reacting the phenolic precursor with a carbonate precursor to prepare a high heat carbonate polymer.

专利号:WO-2025052163-A1
优先权日:2023-09-07
标题:2-amino-n-(benzo[d]thiazol-2-ylsulfonyl)-3-hydroxybutanamide derivatives acting as a threonyl-t-rna synthetase inhbitors for the treatment of malaria
发明人：JIRGENSONS AIGARS; BOLSAKOVA JEKATERINA; BOBROVS RAITIS; VARACEVA LARISA
权利人:LATVIAN INST ORGANIC SYNTHESIS
摘要:Representatives of 2-amino-N-(benzo[d]thiazol-2-ylsulfonyl)-3-hydroxybutanamide with general formula (I) show potency to inhibit malarial threonyl-tRNA synthetase (ThrRS) in low micromolar to nanomolar concentrations. As such they can be applied as compounds for prevention or treatment of malaria.

专利号:US-5919990-A
优先权日:1996-10-15
标题:Reclamation of bisphenol tars as feedstock in the synthesis of aminophenylhydroxphenylalkanes
发明人：LIKIBI PARFAIT J M
权利人:GEN ELECTRIC
摘要:The disclosure is of a process for recovering valuable by-products of the condensation of phenol and a ketone from a mother liquor obtained for example upon crystallization of a 1:1 adduct of phenol and bisphenol, said mother liquor containing phenol, bisphenol, isomers, contaminant by-products of the condensation reaction of phenol with the ketone and acidic impurities. The mother liquor is distilled/evaporated leaving a tarry residue, which is the feedstock for the process of the invention. The recovery comprises heating the feedstock with proportions of an arylamine salt, to extract the bisphenol-A values as aminophenylhydroxylphenyl-alkanes.

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-6562844-B2
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:CN-101070302-A
优先权日:1998-12-21
标题:Synthesis of phenolic monomers containing imide or diimide moieties and heat resistant carbonate polymers prepared therefrom