CAS: 26621-44-3; 3-Nitro-1H-Pyrazole

相似化合物

1820-80-0 38858-89-8 898053-27-5

上下游产品

CAS号7119-95-1 1-硝基吡唑 | CAS号288-13-1 吡唑 | CAS号38858-81-0 1,3-Dinitro-1H-... | CAS号104599-37-3 3,4-二溴-5-硝基-1H-吡唑 | CAS号400753-02-8 4-碘-3-硝基-1H-吡唑 | CAS号89717-64-6 4-溴-3-硝基吡唑 | CAS号7119-95-1 1-硝基吡唑 | CAS号54210-33-2 1-methyl-5-nitr... | CAS号54210-32-1 1-甲基-3-硝基吡唑 | CAS号131394-08-6 AKOS B021108 | CAS号1820-80-0 3-氨基吡唑 | CAS号38858-92-3 3,4-二硝基-1H-吡唑

1-硝基吡唑 反应 16.0H,以79%的收率获得3-硝基吡唑
参考文献:二硝基吡唑的异构体:其理化性质的合成,比较和调整.
标题:二硝基吡唑的异构体:其理化性质的合成,比较和调整.
摘要:通过比文献中描述的略有改进的方法,从容易获得的1H-吡唑开始合成了三种异构体二硝基吡唑(dnp).得到3,4-二硝基吡唑(3),1,3-二硝基吡唑(4)和3,5-二硝基吡唑(5),并就热稳定性,晶体学,灵敏度和高能性能进行比较.两种异构体(3和4)具有高密度(1.79和1.76 G Cm-3)并具有有趣的热行为,可熔融浇铸材料(3:熔融= 71°C,Tdec.= 285oc; 5:熔融= 68°C,Tdec.= 171oc).此外,还有八种盐(钠,钾,铵,肼,羟基铵,胍盐,氨基胍和3,6,7-三氨基-[1,2,4]三唑并[4,3-B] [1,2,4]三唑合成3和5的(totot),以调节性能和灵敏度值.使用1 H,13 C,14 N,15 N NMR和ir光谱以及通过差示扫描量热法进行的质谱分析,元素分析和热分析,对这些化合物进行了表征.通过低温单晶x射线衍射获得14种化合物的晶体结构(3
Doi:10.1002/cplu.201800318

专利信息

专利号:US-11319291-B1
优先权日:2020-06-09
标 题:Continuous flow microfluidic process for synthesis of 3,4-dinitropyrazole
发明人：SCHROER THORSTEN G; LECROY GREGORY E; RODRIGUEZ MAYRA P; WANG SIDA; AGUILA MIGUEL
权利人:US GOV AIR FORCE; US AIR FORCE
摘要:Disclosed herein is a synthetic method, apparatus, and system for the continuous-flow synthesis of 3,4-dinitropyrazole from pyrazole in a microfluidic environment. This synthetic strategy consist of three (3) synthetic steps, including (1) N-nitration of pyrazole, (2) thermal rearrangement into 3-nitropyrazole, and (3) 4-nitration of 3-nitropyrazole. The current technique produces 3,4-dinitropyrazole in yields up to 85% in particular embodiments, in comparison to 40-50% yields demonstrated by the current state of-the-art batch process for large scale synthesis from pyrazole.

专利号:US-5719283-A
优先权日:1990-06-20
标 题:Intermediates useful in the synthesis of pyrazolopyrimidinone antianginal agents
发明人：BELL ANDREW SIMON; BROWN DAVID; TERRETT NICHOLAS KENNETH
权利人:PFIZER
摘要:Compounds of the formula ##STR1## wherein R 1 is H, C 1 -C 3 alkyl, C 3 -C 5 cycloalkyl or C 1 -C 3 perfluoroalkyl; n R 2 is H, C 1 -C 6 alkyl optionally substituted by OH, C 1 -C 3 alkoxy or C 3 -C 6 cycloalkyl, or C 1 -C 3 perfluoroalkyl; n R 3 is H, C 1 -C 6 alkyl, C 3 -C 6 alkenyl, C 3 -C 6 alkynyl, C 3 -C 7 cycloalkyl, C 1 -C 6 perfluoroalkyl or (C 3 -C 6 cycloalkyl)C 1 -C 6 alkyl; n and Y is chloro, bromo, or fluoro. n The above compounds are intermediates useful in the synthesis of certain pyrazolopyrimidinones which inhibit cyclic guanosine 3', 5'-monophosphate phosphodiesterase.

专利号:WO-2016147205-A1
优先权日:2015-03-13
标题 :Novel substituted 3-spirophosphoryl pyrazole-2-oxindoles as anti-infectives and process for the synthesis thereof
发明人：SURYAVANSHI GURUNATH MALLAPPA; SHELKE ANIL MARUTI
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to novel substituted 3-spirophosphoryl, pyrazole-2-oxindoles of Formula (I) and its pharmaceutically acceptable salts, esters, ethers, isomers, stereoisomers, positional isomers and pplymorphs. The present invention further relates to one pot, one step process for the synthesis of spirophosphoiyl pyrazole oxindoles of Formula (I) with yield in the range of 70-85%.

专利号:WO-2006127595-A1
优先权日:2005-05-23
标题:5-aminopyrazole carboxylic acid derivatives and methods of treatment of metabolic-related disorders thereof
发明人：SKINNER PHILIP J; SEMPLE GRAEME; WEBB PETER
权利人:ARENA PHARM INC; SKINNER PHILIP J; SEMPLE GRAEME; WEBB PETER
摘要:The present invention relates to certain pyrazole carboxylic acid or ester derivatives of Formula (I) and pharmaceutically acceptable salts thereof which exhibit useful pharmacological properties, for example, as agonists for the GPCR referred to herein as RUP38. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of metabolic-related disorders, such as, dyslipidemia, atherosclerosis, coronary heart disease, insulin resistance, type 2 diabetes, Syndrome-X and the like. In addition, the present invention also provides for the use of the compounds of the invention in combination with other active agents such as those belonging to the class of -glucosidase inhibitors, aldose reductase inhibitors, biguanides, HMG-CoA reductase inhibitors, squalene synthesis inhibitors, fibrates, LDL catabolism enhancers, angiotensin converting enzyme (ACE) inhibitors, insulin secretion enhancers and the like.

专利号:CN-115957818-B
优先权日:2022-11-11
标题:Synthesis of two-dimensional layered Sm-MOF and separation and catalysis of composite of two-dimensional layered Sm-MOF on water pollutants

专利号:CN-115957818-A
优先权日:2022-11-11
标 题 :Synthesis of two-dimensional layered Sm-MOF and separation and catalysis of compound of Sm-MOF on water pollutants