CAS: 2378-02-1; 1,1,1,3,3,3-Hexafluoro-2-(Trifluoromethyl)Propan-2-Ol

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1515-14-6 920-66-1 7594-49-2

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CAS号81290-20-2 (三氟甲基)三甲基硅烷 | CAS号407-25-0 三氟乙酸酐(TFAH) | CAS号2809-92-9 1,1,1,3,3,3-hex... | CAS号353-50-4 氟光气 | CAS号7594-49-2 1,1,1-三氯-3,3,3-... | CAS号684-16-2 六氟丙酮 | CAS号7440-69-9 铋 | CAS号27579-40-4 [1,1,1,3,3,3-he... | CAS号27579-40-4 [1,1,1,3,3,3-he... | CAS号29646-16-0 九氟-T-丁醇钾 | CAS号26842-85-3 1,1,1,3,3,3-hex...

3-[[1,1,1,3,3,3-Hexafluoro-2-(Trifluoromethyl)Propan-2-Yl]Oxymethyl]-5-Methoxy-1,2-Dimethylindole-4,7-Dione置于nadph:Cytochrome P450 Reductase,还原型辅酶ii(Nadph)四钠盐体系中,用 Water-D2,水,乙腈 用作溶剂,化学反应 0.25H,反应生成高氟叔丁醇
参考文献:Monitoring Of Biological One-Electron Reduction By 19F NMR Using Hypoxia Selective Activation Of An 19F-Labeled Indolequinone Derivative
标题:Monitoring Of Biological One-Electron Reduction By 19F NMR Using Hypoxia Selective Activation Of An 19F-Labeled Indolequinone Derivative
摘要:Biological Reduction Of Fluorine-Labeled Indolequinone Derivative (Iq-F) Was Characterized By F-19 NMR For Quantitative Molecular Understanding. The Chemical Shift Change In F-19 NMR Allowed Monitoring Of The Enzymatic Reduction Of Iq-F. Upon Hypoxic Treatment Of Iq-F With Nadph:Cytochrome P450 Reductase,Iq-F Was Activated Via Catalytic One-Electron Reduction To Release Nonafluoro-Tert-Butyl Alcohol (F-Oh),While The Formation Of F-Oh Was Significantly Suppressed Under Aerobic Conditions. Similar Hypoxia-Selective Reduction Of Iq-F occurred Within A549 Cells,Which Expresses Nadph:Cytochrome P450 Reductase. The Kinetic Analysis Was Also Performed To Propose A Reaction Mechanism. The Molecular Oxygen Slightly Prevents The Binding Of Iq-F To Reductase,While The Rate Of Net Reaction Was Decreased Due To Oxidation Of A Semiquinone Anion Radical Intermediate Generated By One-Electron Reduction Of Iq-F. The Disappearance Of Iq-F And Appearance Of F-Oh Were Imaged By F-19 Fast Spin Echo,Thus Visualizing The Hypoxia-Selective Reduction Of Iq-F By Means Of Mr Imaging.
Doi:10.1021/ja904953B

专利信息

专利号:WO-2013057134-A1
优先权日:2011-10-19
标 题:Synthesis of semiconductor nanoparticles using metal precursors comprising non- or weakly coordinating anions
发明人：BAHNMUELLER STEFAN; TIAN SUSAN; TIAN SHIZHE; HOHEISEL WERNER
权利人:BAYER IP GMBH; BAYER SOUTH EAST ASIA PTE LTD
摘要:The present invention relates to a method for the synthesis of semiconductor nanoparticles comprising elements of the groups IB, IIB, IIIA, IVA, VA or VIA of the periodic classification wherein the composition of the core nanoparticle is selected from the group consisting of IB-VIA, IIB-VIA, IIIA-VIA, IB-IIIA-VIA or IB-IIB-TVA-VIA, IIB-IIIA-VIA, IIB-TVA-VA or mixtures thereof, and at least one shell comprises elements of the groups IIB and VIA,, wherein in case the core composition is IIB-VIA the shell comprises at least a further element selected from the groups IB, IIIA, IVA or VA, using metal precursors comprising non- or weakly coordinating anions. It further relates to the consecutive process for the synthesis that includes first the preparation of a binary nanoparticle system then modified to make a ternary system which again can be further modified to make a quaternary system.

专利号:US-7423171-B2
优先权日:2006-06-20
标题 :One-step catalytic process for the synthesis of isocyanates
发明人：SERRANO FERNANDEZ FRANCISCO LU; ALMENA MUNOZ BEATRIZ; PADILLA POLO ANA; OREJON ALVAREZ ARANCHA; CLAVER CABRERO CARMEN; CASTILLON MIRANDA SERGIO; SALAGRE CARNERO PILAR; AGHMIZ ALI
权利人:REPSOL YPF SA
摘要:A one-pot process for the synthesis of isocyanates, polyisocyanates or mixtures thereof which includes the steps of:n i. preparing a mixture comprising an amine, an alcohol, an oxygen-containing gas, carbon monoxide, a metal complex catalyst selected from the group consisting of macrocyclic complex catalysts and cobalt Shiff base catalysts; and a solvent selected from the group consisting of aliphatic or aromatic halocarbons, perhalogenated alcohols, halogenated ethers, halogenated ketones, perfluorinated hydrocarbons, polymers of chlorotrifluoroethylene having the formula —(CF 2 —CFCl) n wherein n is between 2 and 10, and mixtures thereof; ii. subjecting the resulting mixture to a first heating under pressure; iii. cooling and depressurizing the mixture resulting from the previous step; and iv. subjecting the mixture of the previous step to a second heating to separate out the isocyanate product from the mixture.

专利号:US-2010191010-A1
优先权日:2007-07-02
标题 :Process for the synthesis of carbamates using co2
发明人：BOSMAN JORIS KAREL PETER; CARR ROBERT HENRY
权利人:HUNTSMAN INT LLC
摘要:Process for the synthesis of non cyclic carbamate derivatives from amine compounds, alcohols and CO 2 in the presence of ionic liquids and optionally in the presence of a base.

专利号:US-7759471-B2
优先权日:2005-10-31
标题 :Monomer compositions for the synthesis of RNA, methods of synthesis, and methods of deprotection
发明人：DELLINGER DOUGLAS J; TIMAR ZOLTAN; SIERZCHALA AGNIESZKA; DELLINGER GERALDINE; CARUTHERS MARVIN H
权利人:AGILENT TECHNOLOGIES INC; UNIV COLORADO
摘要:Nucleotide monomers, polynucleotides, methods of making each, methods of deprotecting each, and the like are disclosed herein.

专利号:WO-2024061842-A1
优先权日:2022-09-19
标 题:Improved oligonucleotide synthesis
发明人：CREUSEN GUIDO; MINUTH MARCO; SAMSON DANIEL
权利人:BACHEM HOLDING AG
摘要:A method for the solid-phase synthesis of a target oligonucleotide OT is disclosed, wherein said method comprises a step of incubating a nucleoside or oligonucleotide, which is covalently linked to a solid support and comprises a backbone hydroxyl moiety protected by a di(p-methoxyphenyl)phenylmethyl (DMT) protecting group, with a deprotection mixture, thereby cleaving said protecting group from said nucleoside or oligonucleotide, wherein said deprotection mixture is a liquid composition comprising a solvent, a protic acid having a pKa equal to or smaller than 4, and at least one alcohol of Formula (D), wherein in RD-1 R,D-2 R,D-3 RD-4 and RD-5 are indepently of each other selected from the group consisting of H, OH, a e1-e6-alkyl group, O(C1-C6-aIkyl), C(O)(Ci-C6-alkyl), C(O)O(Ci-C6-alkyl), F, Cl, Br, I, and CN. Such a method does not only suppress depurination, but also results in an acceptable product yield.

专利号:US-10287302-B2
优先权日:2017-06-12
标题 :Method for synthesis of lithium fluorinated borate salts
发明人：YANG JIN; EITOUNI HANY BASAM
权利人:SEEO INC
摘要:An effective method to synthesize Li borate salt such as Li(RfO)aBFb, in which a and b are integers, and a+b=4, has been disclosed. Using RfO-TMS as the starting material enables a streamlined synthesis scheme and makes purification of the final product simple.