CAS: 2140-76-3; 1-((2R,3R,4R,5R)-4-Hydroxy-5-(Hydroxymethyl)-3-Methoxytetrahydrofuran-2-yl)Pyrimidine-2,4(1H,3H)-Dione

相似化合物

4105-38-8 58-96-8 26287-69-4

上下游产品

CAS号83167-64-0 3',5'-O-(1,1,3,... | CAS号121-43-7 硼酸三甲酯 | CAS号847650-91-3 1-((2R,4S,5R)-3... | CAS号3736-77-4 2,2'-脱水尿苷 | CAS号149-73-5 原甲酸三甲酯 | CAS号132278-69-4 3-(4-methoxyphe... | CAS号103285-22-9 DMT保护性-2'-甲氧基尿苷 | CAS号34218-84-3 2'-甲氧基-5-碘-尿苷

尿嘧啶核苷置于碳酸二苯酯,碳酸氢钠体系中,用 甲醇,N,N-二甲基甲酰胺 用作溶剂,化学反应 8.0H,反应生成2'-甲氧基尿苷
参考文献:2'-O-烷基嘧啶核糖核苷的高效大规模合成
标题:2'-O-烷基嘧啶核糖核苷的高效大规模合成
摘要:已经描述了一种以高产率合成 2'-O-烷基嘧啶核糖核苷的有效方法.廉价的方法用于多公斤级合成和优化反应...
Doi:10.1021/op990100T

专利信息

专利号:US-10167308-B2
优先权日:2013-09-14
标题:Highly efficient synthesis of long RNA using reverse direction approach
发明人：SRIVASTAVA SURESH C; SRIVASTAVA NAVEEN P
权利人:CHEMGENES CORP
摘要:The present invention relates to novel process of reverse 5′→3′ directed synthesis of RNA oligomers in the range of about 100-mer to about 200-mer has been developed and disclosed. Using that method demonstrated high quality RNA synthesis with coupling efficiency approaching 99%.

专利号:EP-1108724-B1
优先权日:1996-01-16
标题 :Synthesis of methoxy nucleosides and enzymatic nucleic acid molecules
发明人：WINCOTT FRANCINE; BEIGELMANN LEONID; MATULIC-ADAMIC JASENKA; USMAN NASSIM; HAEBERLI PETER; KARPEISKY ALEXANDER; SWEEDLER DAVID; JARVIS THALE; DIRENZO ANTHONY
权利人:SIRNA THERAPEUTICS INC
摘要:This invention relates to chemical synthesis of 2'-O-methyl, 3'-O-methyl and 5'-O-methyl nucleosides, incorporation of novel chemical modifications in enzymatic nucleic acid molecules and improved methods for the synthesis of enzymatic nucleic acid molecules.

专利号:US-12146136-B2
优先权日:2020-03-26
标题:Synthesis of modified oligonucleotides with increased stability
发明人：KHVOROVA ANASTASIA; ROUX LOÃ?C MAURICE RENÉ JEAN; YAMADA KEN
权利人:UNIV MASSACHUSETTS
摘要:This disclosure relates to the synthesis of novel modified oligonucleotides. The synthesis of novel phosphoramidites are also provided.

专利号:US-2003049619-A1
优先权日:2001-03-21
标题 :Methods for the synthesis of polynucleotides and combinatorial libraries of polynucleotides
发明人：DELAGRAVE SIMON; MARRS BARRY
摘要:Methods for the synthesis of polynucleotides and derivatives thereof are provided. Methods for the preparation of combinatorial libraries of polynucleotides are also provided. In addition, methods for the preparation and identification of polynucleotides having a predetermined property are provided.

专利号:US-2023212204-A1
优先权日:2020-01-16
标题:Reagents and their use for modular enantiodivergent synthesis of c-p bonds
发明人：XU DONGMIN; RIVAS-BASCÓN NAZARET; KNOUSE KYLE W; PADIAL NATALIA; ZHENG BIN; VANTOUROUT JULIEN; SCHMIDT MICHAEL; EASTGATE MARTIN D; BARAN PHI
权利人:BRISTOL MYERS SQUIBB CO; SCRIPPS RESEARCH INST
摘要:The disclosure describes chiral P(V)-based reagents and their uses for the modular, scalable, and stereospecific synthesis of chiral phosphines, phosphine oxides and particular oligonucleotides.

专利号:US-6642367-B2
优先权日:1995-03-06
标 题:Process for the synthesis of 2′-O-substituted pyrimidines and oligomeric compounds therefrom
发明人：COOK PHILLIP DAN; SANGHVI YOGESH S; SPRANKLE KELLY G; ROSS BRUCE S; GRIFFEY RICH H; SPRINGER ROBERT H
权利人:ISIS PHARMACEUTICALS INC
摘要:Oligonucleotide analogs are disclosed having pyrimidine monomeric sub-units therein that are modified at the 2′ and 5′ positions. Monomeric sub-units having these modifications may be further modified at the 2′ position. Improved processes for the synthesis of 2′-O-substituted pyrimidine nucleosides are also provided. The processes feature alkylation of a 2,2′-anhydropyrimidine nucleoside or a 2S,2′-anhydropyrimidine nucleoside with a weak nucleophile in the presence of a Lewis acid.