CAS: 15068-35-6; 2-Chloro-3-Methylbenzoic Acid

该化合物是一种芳烃式的碳酸,其特点是存在一个氯类和一个在苯并酸框架中的甲基组,分子结构特征是带有碳酸(-COOH)功能组的苯环,第二个位置是氯原子,第三个位置是甲基组,与碳酸相比,该化合物一般是白色到非白色的固体,在水中可分解,但在乙醇和丙酮等有机溶剂中可溶性更大,由于可溶解的碳酸组而表现出中度的酸性,氯和甲基分成分的存在可影响其再活性和在有机合成,制药和农用化学化学品中的潜在应用.此外,2-氯-3-甲基苯甲硫酸可作为各种化学化合物合成的中间体,突出其在化学研究和工业中的重要性.

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61563-28-8 920759-93-9 61563-27-7

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2-chloro-1-isopropenyl-3-methyl-benzene 2-amino-5-methyl-6-chlorobenzoic acid 4-chloro-5-methyl-1H-indole-2,3-dione 2-methylchlorobenzene 2-Chloro-5-chlorosulfonyl-3-methyl-benzoic acid 2-chloro-3-methylbenzoyl chloride 3-(4-chlorobenzoyl)-4-chlorotoluene 3-(4-chlorobenzoyl)-4-chlorobenzyl bromide

合成工艺路线路线简述

    📜2-氯甲苯置于sec-Buli体系中,用 四氢呋喃,环己烷 用作溶剂,以15%的收率获得2-氯-3-甲基苯甲酸
    参考文献:3-Aroylbenzylpyridazinone Derivatives
    标题:3-Aroylbenzylpyridazinone Derivatives
    摘要:公式i的化合物:##str1## 其中:R.Sub.10是由公式(A),(B)或(C)表示的基团:##str2## 其他取代基如规范中所定义;它们的药用盐是前列腺素g/h合酶的抑制剂,具有抗炎和镇痛作用.

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    专利信息


    专利号:US-2012115907-A1
    优先权日:2009-04-24
    标题 :Novel compounds as inhibitors of renin
    发明人:THOMBARE PRAVAIN; DESAI JIGAR; JAIN MUKUL R
    权利人:THOMBARE PRAVAIN; DESAI JIGAR; JAIN MUKUL R; CADILA HEALTHCARE LTD
    摘要:The present invention relates to novel renin inhibitors of general formula (1), novel intermediates involved in their synthesis, their pharmaceutically acceptable salts and pharmaceutical compositions containing them. The present invention also relates to a process of preparing compounds of general formula (1), their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.

    专利号:US-7825149-B2
    优先权日:2006-01-19
    标 题 :Substituted imidazoles
    发明人:CHUBB NATHAN ANTHONY LOGAN; COX MARK ROGER; DAUVERGNE JEROME SEBASTIEN; EWIN RICHARD ANDREW; LAURET CHRISTELLE
    权利人:PFIZER LTD
    摘要:This invention relates to a range of alpha substituted 2-benzyl substituted imidazole compounds and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes for their synthesis and their use as parasiticides.

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