CAS: 135729-61-2; (S)-2-((S)-Quinuclidin-3-yl)-2,3,3A,4,5,6-Hexahydro-1H-Benzo[de]Isoquinolin-1-One

上下游产品

(R,R)-Palonosetron
2-<(S)-1-Azabicyclo<2.2.2>Oct-3-Yl>-2,3,3A,4,5,6-Hexahydro-3-Hydroxy-1-Oxo-1H-Benzisoquinoline
(S)-N-(1-氮杂双环环[2.2.2]-3-辛基)-5,6,7,8-四氢-1-萘羧酰胺 N-<(S)-1-Azabicyclo<2.2.2>Oct-3-Yl>-5,6,7,8-Tetrahydronaphthalene-1-Carboxamide 135729-78-1
(3S)-N-[[(1S)-1,2,3,4-四氢-1-萘基]甲基]-1-氮杂双环[2.2.2]辛烷-3-胺 (S)-N-(((S)-1,2,3,4-Tetrahydronaphthalene-1-yl)Methyl)Quinuclidine-3-Amine 177793-80-5

帕洛诺司琼置于palladium On Activated Charcoal 氢气体系中,用 四氢呋喃 用作溶剂,化学反应 139.0H,反应生成帕洛诺司琼
参考文献:Total Synthesis Of The 5-Ht3 Receptor Antagonist Palonosetron
标题:Total Synthesis Of The 5-Ht3 Receptor Antagonist Palonosetron
摘要:我们开发出了一条简捷高效的 5-Ht3 受体拮抗剂 1 和 2(帕洛诺司琼)的合成路线.通过氢化,选择性硼氢化钠还原和脱水,对亚胺 7 的必要中心的氧化态进行了新的调整,得到了 1.亚胺 8 的硼氢化钠还原对 C-3 羧基和芳香环旁的 C-1 羧基具有选择性,从而得到羟基化合物 9.硼氢化钠还原过程中必须保持无氧,否则会产生二元醇 10A 和 10B,成为重要的副产品.
Doi:10.1055/s-1996-4315

专利信息

专利号:US-2022118094-A1
优先权日:2019-02-21
标题:Synthesis of biomimetic cell wall structure
发明人：WANG YONG; SHI PENG
权利人:PENN STATE RES FOUND
摘要:The present invention relates generally to methods of generating a biomimetic cell wall (BCW) on a target surface, compositions comprising the BCW, and methods of use of the compositions, including biomedical applications of the BCW coated compositions.

专利号:US-2018140724-A1
优先权日:2015-05-27
标 题:Tumor Deliverable Iron and Protein Synthesis Inhibitors as a New Class of Drugs for the Diagnosis and Treatment of Cancer
发明人：DENG CHANGCHUN; LIPSTEIN MARK; O'CONNOR OWEN A
权利人:DENG CHANGCHUN; LIPSTEIN MARK; OCONNOR OWEN A; UNIV COLUMBIA
摘要:Tumor deliverable iron (TDI) drugs and pharmaceutical compositions and kits comprising them are provided and methods for delivering iron to tumors specifically, either intracellularly or extracellularly. As a result, TDI drugs are useful as a sensitizer for radiation therapy, radio-diagnosis, and chemotherapy, and are of interest. In other embodiments, tumor deliverable protein synthesis inhibitors (TDPSI) are provided and can be delivered to tumors, but not normal cells. These TDPSI drugs and pharmaceutical compositions and kits comprising them are useful for their treatment of cancer, either alone or in combination with other active anti-cancer drugs.

专利号:US-12071421-B2
优先权日:2011-11-29
标题:Process for the synthesis of substituted chloromethyl dialkylphosphates

专利号:EP-2364312-A4
优先权日:2008-11-11
标题:SYNTHESIS OF CRYSTALLINE PALONOSETRON CHLORHYDRATE

专利号:CN-107089979-B
优先权日:2017-06-29
标 题 :A kind of synthesis technology of palonosetron Hcl hydrochloride

专利号:CN-107290453-B
优先权日:2017-06-29
标题:The HPLC analysis method of palonosetron Hcl synthesis intermediate product