CAS: 122-25-8; 5,5'-Methylenebis(2-Hydroxybenzoic Acid)

该化合物其结构特征为结构特征,有两种硅酸酸糖,由甲苯桥连接,该化合物结构中含有碳酸和氢氧化物组,具有酸性和苯性,通常是白色至白晶状固体,在有机溶剂中可溶解,但在水中溶解性有限,众所周知,该化合物有可能在各个领域应用,包括制药和材料科学,因为它能够形成金属离子复合体及其抗氧化性特性.此外,该化合物可作为其他化学化合物合成的中间体.安全数据表明,应谨慎处理该化合物,因为它可能会引起皮肤或眼睛接触的刺激.

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CAS号50-00-0 甲醛 | CAS号69-72-7 水杨酸 | CAS号1829-32-9 3-氯水扬酸 | CAS号124-38-9 二氧化碳 | CAS号620-92-8 4,4'-二羟基二苯基甲烷 | CAS号119-36-8 水杨酸甲酯 | CAS号7647-01-0 盐酸 | CAS号4431-00-9 金黄三羧酸 | CAS号2346-44-3 4,4'-METHYLENEB... | CAS号620-92-8 4,4'-二羟基二苯基甲烷 | CAS号860756-97-4 2-hydroxy-5-(4-... | CAS号124-38-9 二氧化碳 | CAS号128626-48-2 methyl 2-hydrox... | CAS号639-56-5 5-[bis(3-carbox...

合成工艺路线路线简述

    📜Dimethyl 5,5'-Methylenebis(2-Hydroxybenzoate)置于sodium Hydroxide体系中,用 1,4-二氧六环 用作溶剂,化学反应生成5,5'-亚甲基二水杨酸
    参考文献:Methylenedisalicylic Acid Derivatives: New Ptp1B Inhibitors That Confer Resistance To Diet-Induced Obesity
    标题:Methylenedisalicylic Acid Derivatives: New Ptp1B Inhibitors That Confer Resistance To Diet-Induced Obesity
    摘要:Methylenedisalicylic Acid Derivatives Were Synthesized And Their Inhibitory Activities Against Protein Tyrosine Phosphalases (Ptpases) Examined. Two Of The Compounds,8 And 9,Showed K-I Values Of 9.4 And 6.3 Mu M Against Ptp I B,4-And 7-Fold Lower Values Compared To Those Against Tc-Ptp. They Were Reversible And Slow-Binding Inhibitors Against Ptp I B. When Compound 8 Was Fed To A Mouse Model,The Weight Gain And Adipocyte Fat Storage Induced By A High-Fat-Diet Were Significantly Suppressed. (C) 2007 Elsevier Ltd. All Rights Reserved.
    Doi:10.1016/j.Bmcl.2007.02.069

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    专利信息


    专利号:US-2022089618-A1
    优先权日:2019-01-29
    标题:Solid-State Synthesis Of Precursors Of Metal-Organic Frameworks
    发明人:MAJANO GERARDO J; FALKOWSKI JOSEPH M
    权利人:EXXONMOBIL RES & ENG CO
    摘要:Metal-organic frameworks (MOFs) are highly porous entities comprising a multidentate ligand coordinated to multiple metal atoms, typically as a coordination polymer. MOFs are usually produced from a solvent in powder form under hydrothermal or solvothermal synthesis conditions. Alternately, powder-form precursors of MOFs may be formed by milling or mulling a substantially solid mixture of a metal salt and a multidentate organic ligand, optionally in the presence of a small amount of a solvent. The powder-form precursors may then undergo heating, typically in the absence of applied shear, to produce the corresponding MOF. Mulling may be differentiated from milling at least in that mulling applies to the substantially solid mixture at a non-constant pressure and milling applies a constant pressure while forming the powder-form precursor. In some cases, mulling may promote more effective formation of the powder-form precursor compared to milling.

    专利号:US-10737239-B2
    优先权日:2015-11-27
    标题 :Ultrafast high space-time-yield synthesis of metal-organic frameworks
    发明人:BURCKHART JULIA; MARX STEFAN; ARNOLD LENA; HOFMANN CLAUS; Müller Ulrich
    权利人:BASF SE
    摘要:The invention relates to a process for the preparation of metal-organic frameworks (MOFs) in form of a homogenous powder, and a process wherein the metal-organic framework is molded into shaped bodies.

    专利号:US-9951095-B2
    优先权日:2014-05-16
    标 题:Chromium metal organic frameworks and synthesis of metal organic frameworks
    发明人:ZHOU HONG-CAI; Liu tian-fu; LIAN XIZHEN; ZOU LANFANG; FENG DAWEI
    权利人:TEXAS A & M UNIV SYS
    摘要:The present invention relates to monocrystalline metal organic frameworks comprising chromium ions and carboxylate ligands and the use of the same, for example their use for storing a gas. The invention also relates to methods for preparing metal organic frameworks comprising chromium, titanium or iron ions and carboxylate ligands. The methods of the invention allow such metal organic frameworks to be prepared in monocrystalline or polycrystalline forms.

    专利号:WO-9106589-A1
    优先权日:1989-11-03
    标题 :New anti-hiv compounds belonging to aurintricarboxylic acid
    发明人:HAUGWITZ RUDIGER D; NARAYANAN VENKATACHALA
    权利人:US COMMERCE; PURDUE RESEARCH FOUNDATION
    摘要:The invention relates to the synthesis of compounds with anti-retroviral activity. The synthesis of substantially pure aurintricarboxylic acid monomer and structurally defined polymers, analogs and derivatives thereof, is described. The compounds are shown to have potent anti-retroviral activity, particularly against HIV-1.

    专利号:US-11891406-B2
    优先权日:2019-03-14
    标题:Conductivity enhancement of MOFs via development of MOFpolymer composite material
    发明人:PEEDIKAKKAL ABDUL MALIK P; AL-BETAR ABDUL-RAHMAN; AL-MOUSA AMMAR HUSSAIN
    权利人:UNIV KING FAHD PET & MINERALS
    摘要:A method for enhancing the conductivity of MOF-5 by the development of an MOF-5 polymer composite material. The composite material incorporates a conductive polymer, preferably polyaniline, in the solvo-thermal synthesis pathway of MOF-5. The electrically conductive MOF-5 composite exhibits electric conductivity three orders of magnitude higher than that of MOF-5 while maintaining the crystallinity, robustness, and thermal stability of MOF-5.

    专利号:US-2018333696-A1
    优先权日:2015-11-27
    标题:Ultrafast high space-time-yield synthesis of metal-organic frameworks

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    合成参考文献


    参考文献:10.1021/jm0605132
    摘要:Schepetkin IA, Khlebnikov AI, Kirpotina LN, Quinn MT. Novel small-molecule inhibitors of anthrax lethal factor identified by high-throughput screening. J Med Chem. 2006 Aug 24;49(17):5232–44. doi: 10.1021/jm0605132.
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