CAS: 1191-95-3; Cyclobutanone

上下游产品

CAS号2919-23-5 环丁醇 | CAS号78787-13-0 methyl(1-(methy... | CAS号1120-56-5 亚甲基环丁烷 | CAS号201230-82-2 carbon monoxide | CAS号75-19-4 环丙烷 | CAS号101391-44-0 3-bromobicyclo[... | CAS号6970-72-5 Cyclobutanemeth... | CAS号33745-37-8 bromomethyliden... | CAS号3153-36-4 4-氯丁酸乙酯 | CAS号3772-26-7 N-异丙基-2-吡咯烷酮 | CAS号3470-98-2 1-丁基-2-吡咯烷酮 | CAS号1473-54-7 1-chlor°Cyclobutene | CAS号143140-39-0 methyl 2-cyclob... | CAS号41248-13-9 1-羟基-环丁烷羧酸 | CAS号20434-34-8 1-Butylcyclobutanol

4,4-Dichlorocyclobutenone置于氢气,三乙胺体系中,用 甲醇 用作溶剂,20.0~25.0 °C,200.0 Kpa 条件下,反应 3.0H,以110.5 G的收率获得环丁酮
参考文献:一种环丁酮的制备方法
标题:一种环丁酮的制备方法
摘要:本发明涉及有机合成技术领域,具体涉及一种环丁酮的制备方法,包括如下步骤:三氯乙酰氯在锌粉,三氯氧磷作用下,生成二氯乙烯酮;二氯乙烯酮与乙炔发生环加成反应,生成二氯环丁烯酮;在催化剂作用下,二氯环丁烯酮进行氢化反应得到环丁酮.本发明提供的环丁酮的制备方法反应原料价廉易得,反应步骤简单,收率较高,具有非常好的工业化前景.

专利信息

专利号:US-3852307-A
优先权日:1972-04-25
标 题 :Synthesis of zearalanone and related compounds
发明人：URRY W; MULLENBACH G
权利人:COMMERCIAL SOLVENTS CORP
摘要:WHEREIN X is an integer having a value from 0 to 6 inclusive and Y is an integer having a value from 3 to 8 inclusive. It also provides for new methods of making compounds useful in the synthesis of zearalanone and related compounds. The compounds 6-acetoxyhexanoic acid; 2-(5-hexenoyl)cyclohexanone; 7-keto-11-dodecenoic acid; 2-hydroxyethyl 7-keto11-dodecenoate ethylene ketal; N,N-dimethyl 7-keto-11dodecenamide ethylene ketal; 7-keto-11-dodecenal ethylene ketal; 9-keto-2,13-tetradecadienic acid ethylene ketal; 2-hydroxyethyl 9-keto-2,13-tetradecadienoate ethylene ketal; the sodium salt of ethyl 6-(6-keto-10-undecenyl)- Beta -dihydroresorcylate ethylene ketal; ethyl 3-bromo-6-(6-keto-10-undecenyl)- Beta dihydroresorcylate ethylene ketal; ethyl 6-(6-keto-10-undecenyl)Beta -resorcylate ehtylene ketal; ethyl 6-(6-keto-10-undecenyl)Beta -resorcylate ethylene ketal dibenzyl ether; ethyl 6-(6keto-10-hydroxyundecyl)- Beta -resorcylate ethylene ketal dibenzyl ether; and 6-(10-hydroxy-6-keto-undecyl)- Beta resorcylic acid dibenzyl ether are disclosed. Methods for preparing these compounds are also disclosed. This invention provides a new synthesis for zearalanone and for related compounds having more or fewer carbon atoms in the nonaromatic ring than does zearalanone, which related compounds and zearalanone are represented by the formula

专利号:US-2003083352-A1
优先权日:2000-07-31
标 题 :Synthesis of imidazole intermediates
发明人：HELAL CHRISTOPHER J
权利人:PFIZER
摘要:The invention provides a method for synthesis of compounds of formula n n n wherein R 1 and R 19 are as defined. Compounds of formula 12 are useful as intermediates for synthesizing compounds having pharmacological activity inhibiting cdk5, cdk2, and GSK-3.

专利号:US-9926291-B2
优先权日:2007-03-27
标 题 :Synthesis of thiohydantoins
发明人：OUERFELLI OUATHEK; DILHAS ANNA; YANG GUANGBIN; ZHAO HONG
权利人:SLOAN KETTERING INST CANCER RES
摘要:A novel synthesis of the anti-androgen, A52, which has been found to be useful in the treatment of prostate cancer, is provided. A52 as well as structurally related analogs may be prepared via the inventive route. This new synthetic scheme may be used to prepare kilogram scale quantities of pure A52.

专利号:US-10040752-B2
优先权日:2015-08-24
标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof
发明人：MKRTCHYAN GNEL; YAO QINGWEI
权利人:CODY LABORATORIES INC
摘要:Highly efficient methods for synthesis of levomethadone hydrochloride or dextromethadone hydrochloride are provided starting from D-alanine, or L-alanine, respectively, with retention of configuration. Methods for treating a subject are provided comprising administering a composition comprising an effective amount of levomethadone hydrochloride having not more than 10 ppm dextromethadone.

专利号:US-11441163-B2
优先权日:2020-05-14
标 题:Enzyme-catalyzed synthesis of (1S,5R)-bicyclolactone
发明人：CHEN FENER; ZHU KEJIE; HUANG ZEDU; CHENG DANG; WANG JIAQI; TAO YUAN
权利人:UNIV FUDAN
摘要:An enzyme-catalyzed synthesis of (1S,5R)-bicyclolactone. A first genetically-engineered bacterium containing Baeyer-Villiger monooxygenase gene and a second genetically-engineered bacterium containing glucose dehydrogenase gene are constructed and then suspended with culture medium to prepare a first suspension and a second suspension, respectively. The first and second suspensions are centrifuged to respectively produce a first supernatant containing Baeyer-Villiger monooxygenase and a second supernatant containing glucose dehydrogenase, which are mixed. The mixed supernatant is then mixed with a raceme of a substituted bicyclo[3.2.0]-hept-2-en-6-one, a solvent, a hydrogen donor and a cofactor to perform an asymmetric Baeyer-Villiger oxidation to produce the (1S,5R)-bicyclolactone, where an amino acid sequence of the Baeyer-Villiger monooxygenase is shown in SEQ ID NO:1.

专利号:US-4866175-A
优先权日:1966-11-08
标 题 :Novel process for the synthesis of quinoxaline and benzimidazole-N-oxides
发明人：ISSIDORIDES COSTAS H; HADDADIN MAKHLUF J
权利人:RESEARCH CORP
摘要:The synthesis of quinoxaline and benzimidazole-N-oxides and of ester amd amide derivatives of 3-hydroxy-2-quinoxalinecarboxylic acid by a movel process consisting of the reaction between a benzofuroxan and an activated methylene-containing compound under basic conditions.