CAS: 117354-64-0; 3-Amino-2-(4-Chlorophenyl)-2-Hydroxypropane-1-Sulfonic Acid
- 英文名称3-Amino-2-(4-Chlorophenyl)-2-Hydroxypropane-1-Sulfonic Acid
- 中文名称3-氨基-2-4-氯苯基-2-羟基丙烷磺酸
- IUPAC名称3-Amino-2-(4-chlorophenyl)-2-hydroxypropane-1-sulfonic acid
- 其它别名2-Hydroxysaclofen
- CAS编号117354-64-0
- MFCD编号:MFCD00069282
- EINECS号:634-206-2
- FDA UNII编号:X5IFR0UF10
- 分子式:C9H12ClNO4S分子量:265.71
- 产品CID: 221770
- 产品分类有机原料 → 氨基化合物 → 磺酸类氨基化合物
物理性质
MSDS等安全信息
欧盟法规
ECHA物质C&L通报上下游产品
amine2-(4-chlorophenyl)prop-2-enylamine phthalimideN-2-(4-chlorophenyl)prop-2-enylphthalimide (2S)-1-amino-2-(4-chlorophenyl)-2,3-epoxypropane 2-(4-chlorophenyl)-3-hydroxypropene合成工艺路线路线简述
📜2-(4-Chlorophenyl)Prop-2-En-1-Ol置于platinum(Iv) Oxide 吡啶,Titanium(Iv) Isopropylate,甲醇,叔丁基过氧化氢,Sodium Azide,D-(-)-酒石酸二乙酯,4 A Molecular Sieve,Potassium Tert-Butylate,氢气,Potassium Carbonate,氯化铵,三乙胺,Sodium Sulfite体系中,用 四氢呋喃,甲醇,乙醇,二氯甲烷,水 用作溶剂,-20.0~25.0 °C,344.73 Kpa 条件下,反应 65.09H,反应生成3-氨基-2-4-氯苯基-2-羟基丙烷磺酸
参考文献:The Synthesis Of (R)-(−) And (S)-(+)-Hydroxysaclofen
标题:The Synthesis Of (R)-(−) And (S)-(+)-Hydroxysaclofen
摘要:
Doi:10.1016/0040-4020(95)00710-P
海关参考信息
- 2902600000-乙苯
2902700000-异丙基苯
2903919090-氯苯
2905122000-异丙醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2008146526-A1
优先权日:2006-09-15
标 题 :Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
专利号:US-2009286759-A1
优先权日:2006-09-15
标题:Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
专利号:WO-2008033572-A1
优先权日:2006-09-15
标题:Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
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主要参考文献
1: Varani AP, Pedrón VT, Aon AJ, Höcht C, Acosta GB, Bettler B, Balerio GN. Nicotine-induced molecular alterations are modulated by GABA(B) receptor activity. Addict Biol. 2017 Apr 17. doi: 10.1111/adb.12506. [Epub ahead of print] doi: 10.1016/j.neuropharm.2015.11.013. Epub 2015 Nov 17.
4: Stratton MS, Staros M, Budefeld T, Searcy BT, Nash C, Eitel C, Carbone D, Handa RJ, Majdic G, Tobet SA. Embryonic GABA(B) receptor blockade alters cell migration, adult hypothalamic structure, and anxiety- and depression-like behaviors sex specifically in mice. PLoS One. 2014 Aug 27;9(8):e106015. doi: 10.1371/journal.pone.0106015. eCollection 2014.
5: Varani AP, Aso E, Maldonado R, Balerio GN. Baclofen and 2-hydroxysaclofen modify acute hypolocomotive and antinociceptive effects of nicotine. Eur J Pharmacol. 2014 Sep 5;738:200-5. doi: 10.1016/j.ejphar.2014.05.039. Epub 2014 Jun 2. doi: 10.1016/j.neuropharm.2014.01.030. Epub 2014 Jan 30. doi: 10.1167/iovs.13-12362. doi: 10.1016/j.neuropharm.2013.08.027. Epub 2013 Sep 10.
合成参考文献
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参考文献:10.1152/jn.00427.2004
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摘要:Herrero JF. GABAergic activity of quisqualamine and homoquisqualamine in hemisected spinal cord in vitro preparation. Rev Esp Fisiol. 1994 Mar;50(1):11–7.
参考文献:10.1016/s0014-2999(96)00813-8
摘要:Nyitrai G, Emri Z, Crunelli V, Kékesi KA, Dobolyi A, Juhász G. In vivo blockade of thalamic GABA(B) receptors increases excitatory amino-acid levels. Eur J Pharmacol. 1996 Dec 30;318(2-3):295–300. doi: 10.1016/s0014-2999(96)00813-8.
参考文献:10.1152/jn.1999.82.5.2154
摘要:Chiang CY, Kwan CL, Hu JW, Sessle BJ. Effects of GABA receptor antagonist on trigeminal caudalis nociceptive neurons in normal and neonatally capsaicin-treated rats. J Neurophysiol. 1999 Nov;82(5):2154–62. doi: 10.1152/jn.1999.82.5.2154.
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