CAS: 114899-77-3; (1'R,6R,6Ar,7R,13S,14S,16R)-5-(Acetyloxy)-3',4',6,6A,7,13,14,16-Octahydro-6',8,14-Trihydroxy-7',9-Dimethoxy-4,10,23-Trimethylspiro[6,16-(Epithiopropanoxymethano)-7,13-Imino-12H-1,3-Dioxolo[7,8]Isoquino[3,2-B][3]Benzazocine-20,1'(2'H)-Isoquinolin]-19-One

上下游产品

CAS号114899-80-8 Ecteinascidin 770 | CAS号111726-43-3 5-(甲氧基甲氧基)苯并[d]... | CAS号533-31-3 芝麻酚 | CAS号244126-41-8 5-(methoxymetho... | CAS号488-17-5 3-甲基邻苯二酚 | CAS号244229-56-9 5-bromo-2-metho... | CAS号244126-25-8 5-bromo-2-metho... | CAS号244126-22-5 2-hydroxy-3-met... | CAS号244126-24-7 5-bromo-2-metho...

(1'R,6R,6Ar,7R,13S,14R,16R)-5-(Acetyloxy)-3',4',6,6A,7,13,14,16-octahydro-6'-Hydroxy-7',9-Dimethoxy-8-(Methoxymethoxy)-4,10,23-Trimethyl-19-Oxo-Spiro[6,16-(Epithiopropanoxymethano)-7,13-Imino-12H-1,3-Dioxolo[7,8]Isoquino[3,2-B][3]Benzazocine-20,1'(2'H)-Isoquinoline]-14-Carbonitrile置于三氟乙酸,Silver Nitrate体系中,用 四氢呋喃,水,乙腈 用作溶剂,化学反应 34.0H,反应生成他比特啶
参考文献: Process For The Preparation Of Ecteinascidin Derivative And Its Intermediate[fr] Procédé De Préparation D'Un Dérivé D'Ectéinascidine Et De Son Intermédiaire
标题: Process For The Preparation Of Ecteinascidin Derivative And Its Intermediate[fr] Procédé De Préparation D'Un Dérivé D'Ectéinascidine Et De Son Intermédiaire
摘要:本发明涉及一种改进的,工业上可行的trabectedin制备过程.本发明还涉及一种改进的,工业上可行的公式-A的trabectedin中间化合物制备过程.本发明使用成本更低的试剂,溶剂,并且工艺条件可以很容易地适用于商业规模.

专利信息

专利号:US-10973847-B2
优先权日:2017-06-30
标题 :Core-to-surface polymerization for the synthesis of star polymers and uses thereof
发明人：JOHNSON JEREMIAH A; GOLDER MATTHEW R
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Disclosed are methods, compositions, reagents, systems, and kits to prepare star polymers, as well as compositions and uses thereof. Various embodiments show that synthesis of these polymers contain low metal concentration to provide polymers for diverse biomedical applications including in vivo applications.

专利号:US-7820838-B2
优先权日:2002-01-29
标 题:Method for total synthesis of ecteinascidins and intermediate compounds thereof
发明人：FUKUYAMA TOHRU; KAN TOSHIYUKI
权利人:JAPAN SCIENCE & TECH AGENCY
摘要:An intermediate compound for total synthesis of ecteinascidins comprising, a compound represented by general formula 2 having thioether group at C4 site, and the substituent R 2 of N 12 site is trichloroethoxycarbonyl (Troc) to which various substituents can be introduced by mild condition, further having 10 members ring structure which can be converted to a ring of other numbered members.

专利号:US-2017283878-A1
优先权日:2015-12-11
标题:Modulation of globoseries glycosphingolipid synthesis and cancer biomarkers
发明人：WONG CHI-HUEY; WU CHUNG-YI; CHEUNG SARAH K C; CHUANG PO-KAI; HSU TSUI-LING
权利人:ACADEMIA SINICA
摘要:The present disclosure relates to methods and compositions which can modulate the globoseries glycosphingolipid synthesis. Particularly, the present disclosure is directed to glycoenzyme inhibitor compound and compositions and methods of use thereof that can modulate the synthesis of globoseries glycosphingolipid SSEA-3/SSEA-4/GloboH in the biosynthetic pathway; particularly, the glycoenzyme inhibitors target the alpha-4GalT; beta-4GalNAcT-I; or beta-3GalT-V enzymes in the globoseries synthetic pathway. Additionally, the present disclosure is also directed to vaccines, antibodies, and/or immunogenic conjugate compositions targeting the SSEA-3/SSEA-4/GLOBO H associated epitopes (natural and modified) which elicit antibodies and/or binding fragment production useful for modulating the globoseries glycosphingolipid synthesis. Moreover, the present disclosure is also directed to the method of using the compositions described herein for the treatment or detection of hyperproliferative diseases and/or conditions. Furthermore, the instant disclosure also relates to cancer stem cell biomarkers for diagnostic and therapeutic uses.

专利号:US-2024287041-A1
优先权日:2021-05-20
标题 :Methods of synthesis of heteroaryl derivatives of triazolyl acrylamides and crystalline forms
发明人：BALOGLU ERKAN; AUSTAD BRIAN C; ROE DAVID G; KEDUC ANDREW; GOTTSCHLING STEPHEN EDMUND; HECKER EVAN
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The present invention relates to a method of preparing a compound represented by structural formula (VII), comprising reacting a compound represented by structural formula (II), with a compound represented by structural formula (III), in a solvent, in the presence of a Pd catalyst and one or more inorganic bases under conditions suitable to prepare a compound represented by structural formula (VII): The values and example values of the variables in structural formulas (VII), (II), and (III) are defined herein. The present invention also relates to crystalline Forms I and II of the compound represented by Structural Formula (VII), the use of the crystalline Forms in treating disease or disorders associated with CRM1 and method of preparing the crystalline Forms.

专利号:WO-2007087220-A3
优先权日:2006-01-25
标题:The total synthesis of ecteinascidin 743 and derivatives thereof
发明人：DANISHEFSKY SAMUEL J; CHAN COLLIN
权利人:UNIV COLUMBIA; DANISHEFSKY SAMUEL J; CHAN COLLIN
摘要:This invention provides a method of synthesizing ecteinascidin 743 and derivatives. This invention also provides intermediate compounds and methods of treating tumors.

专利号:US-9227948-B2
优先权日:2012-06-19
标题:Process for the preparation of 2-substituted-2-(6-(substituted)-7-methylbenzo[D][1,3]dioxol-4-yl)acetic acid derivatives
发明人：MUDDASANI PULLA REDDY; CHINTALAPUDI MANIKUMAR; NANNAPANENI VENKAIAH CHOWDARY
权利人:NATCO PHARMA LTD
摘要:Present invention relates to an improved and commercial process for the preparation of 2-sustituted-2-(6-(substituted)-7-methylbenzo[d][1,3]dioxol-4-yl)acetic acid derivatives of formula-I the above Formula I, XII, XIII, XV, wherein R 1 is a O-protecting group such as methoxymethyl, ethoxymethyl, trialkylsilyl, arylmethyl, tetrahydropyran-2-yl, allyl; X is hydroxyl, halogen, mesylate, triflate, tosylate, acetate; Y is oxygen atom, NH or sulfur atom; R 2 is C 1 -C 6 alkyl. 2,4-Dihydroxy-3-methylbenzaldehyde is selectively protected at C-4 position in the form of an ether compound of formula-XII, oxidized the aldehyde function to get the diol of formula-XIII, and condensed with ethyl glyoxalate under Casiraghi reaction conditions to get the compound of formula-XV. Compound of formula-XV is converted to compound of formula-I by conventional chemistry. Compounds of formula-I are key intermediates in the synthesis of ecteinascidines like trabectedin.