CAS: 101711-78-8; (S)-4-Benzyl-3-Propionyloxazolidin-2-One

上下游产品

(S)-4-Benzyl-2-oxazolidinone propionyl chloride propionic acid propionic acid anhydride (S)-4-benzyl-3-((R,E)-2-methyl-5-phenylpent-4-enoyl)oxazolidin-2-one (4S,2'R)-3-(3'-(benzyloxy)-2'-methylpropanoyl)-4-benzyl-1,3-oxazolidin-2-one -3--4-benzyl-2-oxazolidinone3(2S,3R)4S-3-3-hydroxy-2-methyl-6-heptenoyl-4-benzyl-2-oxazolidinone -3-(2-Methyl-1-oxo°Ctyl)-4-(phenylmethyl)-2-oxazolidinone3(2'R),4S-3-(2-Methyl-1-oxo°Ctyl)-4-(phenylmethyl)-2-oxazolidinone

(S)-4-苄基-2-唑烷酮 以 正己烷 用作溶剂,化学反应生成(S)-4-苄基-3-丙酰基-2-噁唑烷酮
参考文献:Diastereoisomers Of N.Sup.6-Endo-Bicyclo[2.2.1]Heptyladenosine As
标题:Diastereoisomers Of N.Sup.6-Endo-Bicyclo[2.2.1]Heptyladenosine As
摘要:(1R-Endo)或(1S-Endo)-N-双环[2.2.1]庚基腺苷及其药用酸盐,具有极具吸引力的降压特性和意外的a.Sub.1和a.Sub.2受体结合活性,其制造过程,制药组合物和使用该化合物和组合物的方法.

专利信息

专利号:US-6093812-A
优先权日:1991-07-23
标 题 :Process for the stereospecific synthesis of azetidinones
发明人：THIRUVENGADAM TIRUVETTIPURAM K; TANN CHOU-HONG; LEE JUNNING; MCALLISTER TIMOTHY; COLON CESAR; BARTON DEREK H R; BRESLOW RONALD; SUDHAKAR ANANTHA
权利人:SCHERING CORP
摘要:This invention provides an improved process for producing azetidinones. More particularly, this invention provides the steps of producing an trans-azetidinone represented by the formula from a carboxylic acid R2-D-CH2COOH, an aldehyde R1-A-CHO and an amine RNH2, by the steps of: (a1) converting a carboxylic acid to the corresponding acid chloride; (b1) deprotonating a chiral oxazolidinone and treating the resulting anion with the product of step (a1); (c1) enolizing the product of step (b1) and condensing with the aldehyde; (d1) hydrolyzing the product of step (c1); (e1) condensing the product of step (d1) with the amine; and (f1) cyclizing the product of step (e1). Alternatively, the process comprises (a2) enolizing the product of step (b1) and condensing, in the presence of a Lewis acid, with a Schiff's base prepared from the aldehyde and the amine; and (b2) cyclizing the product of step (a2).

专利号:US-6340751-B1
优先权日:1998-07-24
标 题 :Process for the preparation of 4-substituted azetidinone derivatives
发明人：SAITO TAKAO; MURAYAMA TOSHIYUKI; MATSUMOTO TAKAJI; MIURA TAKASHI
权利人:TAKASAGO PERFUMERY CO LTD
摘要:Disclosed is a process for the preparation of a 4-substituted azetidinone derivative, which comprises reacting an azetidinone derivative and an amide compound in the presence of a magnesium compound such as those represented by the following formulas (II): n and (IV): n represented by the following formula (III): n n n MgR 5 R 6   (III) n n n wherein R 5 represents a C 1-12 alkyl group, a C 2-5 alkenyl group, a 5- to 8-membered alicyclic group which may be substituted by a lower C 1-4 alkyl group, a phenyl group which may be substituted by a lower C 1-4 alkyl group, a lower C 1-4 alkoxy group or a halogen atom or a benzyl group which may be substituted by a lower C 1-4 alkyl group, a lower C 1-4 alkoxy group or a halogen atom, and R 6 represents a halogen atom, a methanesulfonyloxy group, a benzenesulfonyloxy group, a p-toluenesulfonyloxy group, a trifluoromethanesulfonyloxy group, an acetoxy group which may be substituted by a halogen atom or a cyano group or an OR 7 group (R 7 representing a lower C 1-4 alkyl group, a substituted or unsubstituted phenyl group or a substituted or unsubstituted benzyl group). The process provides an industrially excellent process for the preparation of a 4-substituted azetidinone derivative which permits the selective preparation of an intermediate for the synthesis of a carbapenem antibacterial agent having a desired 1-β′ configuration.

专利号:US-7700783-B2
优先权日:2003-10-09
标题 :Synthesis of discodermolide and variants thereof
发明人：SMITH III AMOS B; FREEZE BRIAN SCOTT; XIAN MING
权利人:UNIV PENNSYLVANIA
摘要:Processes for synthesizing a compound of Formula (I) are provided by reacting a compound of Formula (i) with a compound of Formula (xx).

专利号:US-5132457-A
优先权日:1991-08-26
标 题 :Stereospecific synthesis of 2(R)-2-methyl-3-dimethylamino-propiophenone (d-DAMP)
发明人：MATHEW JACOB
权利人:MALLINCKRODT SPEC CHEM
摘要:In a method for producing 2(R)-2-methyl-3-dimethylamino-propiophenone (d-DAMP), a chiral ester of the formula ##STR1## wherein R is an alkyl of from 1 to about 5 carbon atoms, is provided. The chiral easter of formula (I) is converted into a chiral amino-alcohol of the formula ##STR2## and the chiral amino-alcohol is oxidized so as to form d-DAMP.

专利号:US-2011144326-A1
优先权日:2009-12-10
标题:Method for manufacturing stereoselective preparation of 4-BMA using a chiral auxiliary and chiral auxiliary
发明人：TSENG WEI-HONG; CHUANG SHIUAN-TING; HUNG ZUN-YUAN; WU CHING-I
权利人:TSENG WEI-HONG; CHUANG SHIUAN-TING; HUNG ZUN-YUAN; WU CHING-I
摘要:The present invention relates to a process for preparing (3R,4S)-3-[[[R]-1′-t-butyldimethylsilyloxy]ethyl]-4-[(R)-1″-carboxyethyl]-2-azetidinone (beta-methylazetidin-2-one; 4-BMA), a key intermediate for the synthesis of carbapenem and penem antibiotics. Specifically, the present invention relates to a process comprising first, the preparation of a chiral auxiliary from cheap L-Phenylalaninol, and then the preparation of 4-BMA in high yield and high selectivity, under industrially mild condition.

专利号:EP-2345645-A1
优先权日:2009-12-22
标题 :Method for manufacturing stereoselective preparation of 4-bma using a chiral auxiliary and chiral auxiliary
发明人：TSENG WEI-HONG; CHUANG SHIUAN-TING; HUNG ZUN-YUAN; WU CHING-I
权利人:SAVIOR LIFETEC CORP
摘要:The present invention relates to a process for preparing (3R,4S)-3- [[[R]-1 ' -t-butyldimethylsilyloxy ]ethyl]-4-[(R)-1 '-carboxyethyl]-2-azetidinone (beta- methylazetidin-2-one; 4-BMA), a key intermediate for the synthesis of carbapenem and penem antibiotics. Specifically, the present invention relates to a process comprising first, the preparation of a chiral auxiliary from cheap L-Phenylalaninol, and then the preparation of 4-BMA in high yield and high selectivity, under industrially mild condition.