CAS: 1003-29-8; 1H-Pyrrole-2-Carbaldehyde

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161282-57-1 102619-05-6 1193-62-0

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CAS号4513-94-4 吡咯-2-甲腈 | CAS号109-97-7 吡咯 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号161282-57-1 N-B°C-吡咯-2-甲醛 | CAS号32597-34-5 1H-吡咯-2-甲醛肟 | CAS号74-86-2 乙炔 | CAS号86688-93-9 1-(苯磺酰)-2-吡咯甲醛 | CAS号132407-64-8 trifluoromethan... | CAS号104501-02-2 1H-Pyrrole-2-ca... | CAS号105090-44-6 1,3,3-triphenyl... | CAS号34649-21-3 4,5-二溴-1H-吡咯-2-羧酸 | CAS号32597-34-5 1H-吡咯-2-甲醛肟 | CAS号4513-94-4 吡咯-2-甲腈 | CAS号33515-62-7 4-碘-1H-吡咯-2-甲醛 | CAS号310436-61-4 4-溴吡咯并[1,2-f][1... | CAS号408309-29-5 3-(1H-吡咯-2-基)丙酸 | CAS号145041-27-6 1H-Pyrrole-1-ac... | CAS号14942-62-2 N,N'-bis(pyrrol...

吡咯-2-羧酸置于carboxylic Acid Reductase体系中,化学反应生成2-吡咯甲醛
参考文献:羧酸还原酶在合成化学工具箱中作为酶的表征
标题:羧酸还原酶在合成化学工具箱中作为酶的表征
摘要:羧酸还原酶(cars)满足合成化学中从其各自的羧酸到醛的绿色和区域特异性路线的需求.然而,这些酶中相对较少的已被表征.与anl(酰基辅酶a合成酶/ Nrps腺苷酸化结构域/荧光素酶)超家族成员的序列比对揭示了car功能动力学.通过对已知和假设的car进行系统发育分析,选择了四种未研究的酶,并且首次进行了全面的生化表征.这些酶与各种底物的动力学分析表明,它们具有广泛但相似的底物特异性.富含电子的酸是受欢迎的,这表明拟议的反应机理的第一步是 羧酸盐对三磷酸腺苷(atp)的α-磷酸酯的攻击是决定底物特异性和反应动力学的步骤.Ph和温度的影响为这些car的使用提供了清晰的操作窗口,而nadp对产物抑制的研究+,单磷酸腺苷和焦磷酸表示底物在腺苷酸化域的结合是有序的,首先是atp结合.这项研究将cars整合为可持续化学工具箱中重要且令人兴奋的酶,并提供了将其用作生物催化剂的规格.
Doi:10.1002/cctc.201601249

专利信息

专利号:US-11427596-B2
优先权日:2019-07-19
标 题:Metal-free solvent-free synthesis of fused-pyrido heterocycles and biomedical applications
发明人：CHELVAM VENKATESH; DUDHE PREMANSH; KRISHNAN MENA ASHA; SONAWANE AVINASH
权利人:INDIAN INSTITUTE OF TECH INDORE
摘要:Embodiments herein provide fused-pyrido heterocycles such as azaindoles, carboline derivatives, furo[b]pyridines or furo[b]pyridine-isatin hybrids of Formula I.Embodiments also relate to a process for a synthesis of variety of complex pyrido-heterocycles The pyrido-heterocycles can be used for treating cancer (cervix, kidney, lung, breast and epidermal skin) and multi-drug resistant tuberculosis. These heterocycles can also be used as anti-biofilm agents against pathogenic strains, which will minimize the risk of secondary infections.

专利号:WO-03031376-A1
优先权日:2001-10-12
标 题 :Solid phase synthesis of substituted 1,5-benzodiazepine-2-one and 1,5-benzothiazepine-2-one
发明人：MORTON GEORGE C; SALVINO JOSEPH M; LABAUDINIERE RICHARD F; HERPIN TIMOTHY F
权利人:AVENTIS PHARMA INC; MORTON GEORGE C; SALVINO JOSEPH M; LABAUDINIERE RICHARD F; HERPIN TIMOTHY F
摘要:A solid phase synthetic method for making substituted 1,5-benzodiazepine-2-one or 1,5-benzothiazepine-2-one. The method is useful for synthesis of large numbers of compounds through automated parallel synthesis or combinatorial library generation and is thus important to rapid discovery or new therapeutic agents containing the base structure of 1,5-benzodiazepine-2-one or 1,5-benzothiazepine-2-one.

专利号:US-7138526-B1
优先权日:1999-06-15
标 题 :Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives
发明人：HERPIN TIMOTHY F; MORTON GEORGE C; SALVINO JOSEPH M
权利人:AVENTIS PHARMA INC
摘要:A method for the solid phase synthesis of N,N-disubstituted diazacycloalkylcarboxy derivatives of general formula (I) and (II) is claimed. Examples include piperazine-2-carboxamide. The method is applicable to the synthesis or large combinatorial libraries

专利号:US-6127515-A
优先权日:1997-11-18
标 题:Functionalized resin for the synthesis of amides and peptides
发明人：MANFRE FRANCO; VANASSE BENOIT J; LABAUDINIERE RICHARD F; MORTON GEORGE C
权利人:AVENTIS PHARM PROD INC
摘要:This invention is directed to a functionalized amino resin of formula ##STR1## wherein S is a solid support; R is H or alkyl; A is ##STR2## Y is OH or OCOR 1 ; and R 1 is aliphatic or aromatic which is useful for the solid phase synthesis of amides, peptides and hydroxamic acids.

专利号:US-10919904-B2
优先权日:2016-08-17
标 题 :Northern-southern route to synthesis of bacteriochlorins
发明人：LIU YIZHOU; LINDSEY JONATHAN S; ALLU SRINIVASA RAO; FUJITA HIKARU
权利人:UNIV NORTH CAROLINA STATE
摘要:Described herein are chlorins, bacteriochlorins, methods and intermediates for the synthesis of bacteriochlorins, and methods of using such bacteriochlorins for, among other things, diagnostic and therapeutic purposes such as luminescent compounds in flow cytometry, and as active agents in photodynamic therapy (PDT).

专利号:US-6133409-A
优先权日:1996-12-19
标 题:Process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and αβ-unsaturated carboxylic acid and aldehyde compounds
发明人：SALVINO JOSEPH M; MORTON GEORGE C; MASON HELEN J; LABAUDINIERE RICHARD F
权利人:AVENTIS PHARM PROD INC
摘要:This invention is directed to a process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and alpha , beta -unsaturated carboxylic acid and aldehyde compounds and to polymeric hydroxylamine resin compounds useful therefor.