专利号:EP-1567195-B1 优先权日:2002-11-26 标题 :Dendrimer conjugates for selective solubilisation of protein aggregates 发明人:HEEGAARD PETER; BOAS ULRIK 权利人:UPFRONT CHROMATOGRAPHY AS 摘要:Dendrimer conjugates are presented, which are formed between a dendrimer and a protein solubilising substance. Such dendrimer conjugates ar effective in the treatment of protein aggregate-related diseases (e.g. prion-related diseases). The protein solubilising substance and the dendrimer together show a protein aggregate solubilising effect higher than a physical mixture of the dendrimer and the protein solubilising substance (i.e. a synergistic effect). Such dendrimer conjugates are useful in the treatment or prevention of protein aggregate-relates diseases, in disinfection/decontamination processes and in classifying or identifying protein aggregates. The synthesis of such dendrimer conjugates from readily-available starting materials is described.
专利号:US-8580822-B2 优先权日:2006-12-11 标 题:Compositions, synthesis, and methods of using indanone based cholinesterase inhibitors 发明人:BHAT LAXMINARAYAN; MOHAPATRA PRABHU PRASAD 权利人:BHAT LAXMINARAYAN; MOHAPATRA PRABHU PRASAD; REVIVA PHARMACEUTICALS INC 摘要:The present invention provides novel indanone derivatives which can be advantageously used for treating and/or preventing of a medical condition for which inhibition of a cholinesterase is desired.
专利号:US-7737166-B2 优先权日:2005-08-17 标 题:Antifungal bicyclic hetero ring compounds 发明人:KAWAKAMI KATSUHIRO; KANAI KAZUO; HORIUCHI TAKAO; TAKESHITA HIROSHI; KOBAYASHI SYOZO; SUGIMOTO YUICHI; ACHIWA ISSEI; KUROYANAGI JUNICHI 权利人:DAIICHI SANKYO CO LTD 摘要:A 1,6-β-glucan synthetase inhibitor is provided, having potent growth inhibition and having excellent safety. A compound is provided, capable of expressing in a wide spectral range and specifically or selectively, an antifungal effect based on its functional mechanism of 1,6-β-glucan synthesis inhibition. Also provided is a drug, a salt or hydrate thereof, especially an antifungal that contains the compound. Concretely, provided is a compound of the following formula (I), its salt or hydrate, and a drug or antifungal containing, as the active ingredient, the compound, its salt or hydrate:
专利号:US-2008153878-A1 优先权日:2006-12-11 标题:Compositions, synthesis, and methods of using indanone based cholinesterase inhibitors
专利号:US-8247563-B2 优先权日:2006-12-11 标题 :Compositions, synthesis, and methods of using indanone based cholinesterase inhibitors
专利号:US-2012252842-A1 优先权日:2006-12-11 标题 :Compositions, synthesis, and methods of using indanone based cholinesterase inhibitors
参考标题:Total Synthesis Of Fontanesine B And Its Isomer: Their Antiproliferative Activity Against Human Colorectal Cancer Cells 作者:Takumi Abe,Tomoki Itoh,Masaru Terasaki |发布日期:2019.7 摘要:A Concise Synthesis Of Pyrano[3,2‐e]Indole Alkaloid Fontanesine B By A Fischer Indolization Is Described. This Key Fischer Indolization Starts With The Pyran‐ring And Alkene Intact, Facilitating Potential Synthetic Applications. Furthermore, Fontanesine B And Its Isomer Were Evaluated For In Vitro Antiproliferative Activity Against Human Colorectal Cancer Cells. The Isomer Of Fontanesine B Showed Higher
合成参考文献
摘要:Dissertationes Pharmaceuticae et Pharmacologicae., 18(229), 1966 摘要:Archives Internationales de Pharmacodynamie et de Therapie., 145(233), 1963 []