CAS: 676596-65-9; 9-Bromo-7,12-Dihydropyrido[3',2':2,3]Azepino[4,5-B]Indol-6(5H)-One

该化合物是环状依赖性动脉(CDKs),特别是CDK1,CDK2,CDK2和CDK5的强大和选择性抑制器,其抗甘醇合成酶3-3β(GSK-3β)的明显活动得到证实.这种细胞透析化合物广泛用于生物化学和药理研究,以调查细胞循环调节,...

结构式图片

合成工艺路线路线简述

    海关参考信息

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Hazlitt RA, Teitz T, Bonga JD, Fang J, Diao S, Iconaru L, Yang L, Goktug AN, Currier DG, Chen T, Rankovic Z, Min J, Zuo J. Development of Second-Generation CDK2 Inhibitors for the Prevention of Cisplatin-Induced Hearing Loss. J Med Chem. 2018 Sep 13;61(17):7700-7709. doi: 10.1021/acs.jmedchem.8b00669. Epub 2018 Aug 24. doi: 10.3389/fimmu.2018.01339. eCollection 2018.
    4: Joo HC, Choi JW, Moon H, Lee CY, Yoo KJ, Kim SW, Hwang KC. Protective effects of kenpaullone on cardiomyocytes following H(2)O(2)-induced oxidative stress are attributed to inhibition of connexin 43 degradation by SGSM3. Biochem Biophys Res Commun. 2018 May 5;499(2):368-373. doi: 10.1016/j.bbrc.2018.03.166. Epub 2018 Mar 26. doi: 10.1292/jvms.17-0556. Epub 2018 Mar 8.
    6: Teitz T, Fang J, Goktug AN, Bonga JD, Diao S, Hazlitt RA, Iconaru L, Morfouace M, Currier D, Zhou Y, Umans RA, Taylor MR, Cheng C, Min J, Freeman B, Peng J, Roussel MF, Kriwacki R, Guy RK, Chen T, Zuo J. CDK2 inhibitors as candidate therapeutics for cisplatin- and noise-induced hearing loss. J Exp Med. 2018 Apr 2;215(4):1187-1203. doi: 10.1084/jem.20172246. Epub 2018 Mar 7.
    📝 需求与反馈
    尽可能描述清楚需求与问题信息
    ×

    通知