合成目标产物 3-Amino-1,2,4-Triazole 主要起始原料 5-Mercapto-1,2,3-Triazole Monosodium Salt And Azidotrimethyltin And 4-Bromo Methylbenzyl Alcohol
(文献来源)合成步骤主要原料 5-Mercapto-1,2,3-Triazole Monosodium Salt 和 Azidotrimethyltin 和 4-Bromo Methylbenzyl Alcohol
专利信息
专利号:US-2012107923-A1 优先权日:2010-08-06 标题 :Expression vectors which inhibit synthesis of catalase and uses thereof 发明人:ISRAEL JACARD YEDY; GONZALEZ MARIA ELENA QUINTANILLA; TAMPIER DE JONG LUTSKE; BUSTAMANTE CADIZ ALVARO DIEGO; HERRERA MARSCHITZ MARIO; KARAHANIAN VARTEVANIAN EDUARDO 权利人:ISRAEL JACARD YEDY; GONZALEZ MARIA ELENA QUINTANILLA; TAMPIER DE JONG LUTSKE; BUSTAMANTE CADIZ ALVARO DIEGO; HERRERA MARSCHITZ MARIO; KARAHANIAN VARTEVANIAN EDUARDO 摘要:Vector and application of a medicine/drug that inhibits the intake of alcohol for prolonged periods, by inhibiting the synthesis of brain catalase or by destroying the product that is generated when brain catalase acts upon ethyl alcohol.
专利号:WO-2010049789-A1 优先权日:2008-10-27 标 题 :Process for the synthesis of fipronil 发明人:JUELICH ALEXANDER; TILLICH JOACHIM 权利人:DYNAMIT NOBEL AG; JUELICH ALEXANDER; TILLICH JOACHIM 摘要:This invention relates to a process for the continuous synthesis of 5-amino-1-[2,6- dichloro-4-(rifluoromethyl)phenyl]-4-(rifluoromethylsulfinyl)-1H-pyrazole-3-carbonitrile comprising the step of reacting in a solvent 5-amino-1-[2,6-dichloro-4- (trifluoromethyl)phenyl]-4-(trifluoromethylthio)-1H-pyrazole-3-carbonitrile with an oxidizing agent. The process provides a more efficient and more robust process than the existing processes.
专利号:US-9988488-B2 优先权日:2013-03-26 标 题:Catalyst for poly(lactide) synthesis and uses thereof 发明人:CHAKRABORTY DEBASHIS; GHOSH SWARUP; RAMKUMAR VENKATACHALAM 权利人:INDIAN INSTITUTE OF TECH MADRAS 摘要:A catalysts for poly(lactide) synthesis having the structure of Formula I: n nwherein R 1 and R 2 is, independently, C 1 -C 6 alkoxy, and R 3 arylalkyl or substituted phenyl are disclosed. Method of synthesizing the catalysts and method of using the catalysts to prepare poly(lactides) and compositions comprising the catalyst are also disclosed.
专利号:US-2025304985-A1 优先权日:2022-04-08 标题 :Genetically Engineered Plants for Increased Production of Vindoline 发明人:LEE-PARSONS CAROLYN; COLE LAUREN F 权利人:UNIV NORTHEASTERN 摘要:Two novel transcription factors, CrDELLA1 and CrDELLA2, are described in Catharanthus roseus plants. The DELLA transcription factors have a regulatory role in the synthesis of vinblastine and vincristine, two important anti-cancer compounds that have proved difficult to obtain in sufficient quantities. The present technology provides genetically modified C. roseus plants having enhanced DELLA activity, which leads to activation of multiple enzymes in the biosynthetic pathway leading to vinblastine and vincristine. The genetic modifications can be used together with activation of plant defense mechanisms and responses to light in order to boost vinblastine and vincristine synthesis.
专利号:WO-2014011120-A1 优先权日:2012-07-13 标 题 :Endoperoxides, synthesis and uses thereof for the treatment of neoplastic diseases such as cancer 发明人:TAN NGUAN SOON; CHIBA SHUNSUKE 权利人:UNIV NANYANG TECH 摘要:The present invention generally relates to processes and methods for the synthesis of endoperoxide compounds. More specifically, the invention relates to a method for preparing endoperoxide compounds starting from an aryl imine of formula (I) in the presence of a metallic catalyst and oxygen. The present invention also relates to endoperoxide compounds of formula (III) and their pharmaceutically acceptable salts thereof, useful for therapy. All substituents are defined herein. Also disclosed are methods of treating cancer using the compounds of formula (III).
专利号:US-2005239808-A1 优先权日:2002-05-10 标题 :Active substances for the treatment, diagnosis and prophylaxis of diseases in which abnormal protein structures occur 发明人:SCHRADER THOMAS; RIESNER DETLEV; RZEPECKI PETRA; NAGEL-STEGER LUITGARD; WEHNER MARK; KIRSTEN CHRISTIAN; MOLT OLIVER; ZADMARD REZA; ASCHERMANN KATJA 权利人:SCHRADER THOMAS; RIESNER DETLEV; RZEPECKI PETRA; NAGEL-STEGER LUITGARD; WEHNER MARK; KIRSTEN CHRISTIAN; MOLT OLIVER; ZADMARD REZA; ASCHERMANN KATJA 摘要:The invention on hand refers to diseases associated with abnormal protein structures, including Alzheimer's disease, Creutzfeldt-Jakob's disease, BSE and other prion-associated diseases. It is the task of the invention on hand to provide new active agents preventing the formation of amyloid plaques and to dissolve existing plaques, such agents being convenient for therapy, diagnosis and prophylaxis of diseases that are associated with abnormal protein structures. This task is performed in terms of the current invention by heterocyclic or aromatic agents with a rigid structure and a donor-acceptor-donor pattern (DAD), the latter being formed by donors and acceptors of hydrogen bridge linkages which comply with the β-sheet structure of the peptide or protein and thus fit as binding partners. The heterocyclic or aromatic agents are available at least as dimers. They recognise peptides and proteins with a β-sheet structure, form stable complexes with them and inhibit their aggregation to β-amyloid plaques. Furthermore, the new active agents are able to dissolve β-amyloid plaques that already exist. Another task of the current invention is to provide methods for the synthesis of said heterocyclic or aromatic compounds.
[参考文献]: Dandan Mao, Et Al. Feronia Receptor Kinase Interacts With S-Adenosylmethionine Synthetase And Suppresses S-Adenosylmethionine Production And Ethylene Biosynthesis In Arabidopsis. Plant Cell Environ. 2015 Dec;38(12):2566-74. [参考文献]: K E Olney, Et Al. Inhibitors Of Hydroperoxide Metabolism Enhance Ascorbate-Induced Cytotoxicity. Free Radic Res. 2013 Mar;47(3):154-63. [参考文献]: Katrin Scheit, Et Al. Direct And Indirect Inactivation Of Tumor Cell Protective Catalase By Salicylic Acid And Anthocyanidins Reactivates Intercellular Ros Signaling And Allows For Synergistic Effects. Carcinogenesis. 2015 Mar;36(3):400-11. [参考文献]: Leila Tajedin, Et Al. Plasmodium Falciparum Xpd Translocates In 5' To 3' Direction, Is Expressed Throughout The Blood Stages, And Interacts With P44. Protoplasma. 2015 Nov;252(6):1487-504. [参考文献]: Lourdes Santana, Et Al. Quantitative Structure-Activity Relationship And Complex Network Approach To Monoamine Oxidase A And B Inhibitors. J Med Chem. 2008 Nov 13;51(21):6740-51.
合成参考文献
参考文献:10.1152/ajprenal.00201.2011 摘要:Gauthier KM, Olson L, Harder A, Isbell M, Imig JD, Gutterman DD, Falck JR, Campbell WB. Soluble epoxide hydrolase contamination of specific catalase preparations inhibits epoxyeicosatrienoic acid vasodilation of rat renal arterioles. American Journal of Physiology-Renal Physiology. 2011 Oct;301(4):F765–72. doi: 10.1152/ajprenal.00201.2011. 参考文献:10.1107/s1600536811006751 摘要:Chernyshev VM, Mazharova AG, Rybakov VB. 4-Benzyl-3-[(1-oxidoethylidene)amino]-1-phenyl-4,5-dihydro-1H-1,2,4-triazol-5-iminium. Acta Crystallogr Sect E Struct Rep Online. 2011 Apr 01;67(Pt 4):o870–1. 参考文献:10.1007/s00213-011-2407-0 摘要:Ledesma JC, Aragon CM. α-Lipoic acid, a scavenging agent for H₂O₂, reduces ethanol-stimulated locomotion in mice. Psychopharmacology (Berl). 2012 Jan;219(1):171–80. doi: 10.1007/s00213-011-2407-0. 参考文献:10.1007/s00294-005-0021-6 摘要:Kaadige MR, Lopes JM. Analysis of Opi1p repressor mutants. Curr Genet. 2006 Jan;49(1):30–8. doi: 10.1007/s00294-005-0021-6.