CAS: 57982-77-1; (S)-1-((3S,6S,9S,12S,15R,18S,21S)-3-((1H-Imidazol-5-yl)Methyl)-6-((1H-Indol-3-yl)Methyl)-15-(Tert-Butoxymethyl)-21-(3-((Diaminomethylene)Amino)Propyl)-12-(4-Hydroxybenzyl)-9-(Hydroxymethyl)-18-Isobutyl-1,4,7,10,13,16,19-Heptaoxo-1-((S)-5-Oxopyrrolidin-2-yl)-2,5,8,11,14,17,20-Heptaazadocosan-22-Oyl)-N-Ethylpyrrolidine-2-Carboxamide

Pglu-His-Trp-Ser-Tyr(Bzl)-D-Ser(Tbu)-Leu-Arg(No2)-Pro-Nhet置于5% Palladium Over Charcoal 氢气体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应生成 布舍瑞林
参考文献:Methods For The Production Of Peptide Derivatives
标题:Methods For The Production Of Peptide Derivatives
摘要:这项发明涉及一种通过固相合成和后组装溶液相合成相结合的方法制备c-末端酰胺衍生物的肽.这些c-末端酰胺衍生物的肽进一步转化为肽醋酸酯.该发明还涉及纯肽醋酸酯和受保护的肽前体.

专利信息

专利号:US-12383499-B2
优先权日:2018-01-01
标题:Scale up synthesis of silicasome nanocarriers
发明人：NEL ANDRE E; MENG HUAN; LIU XIANGSHENG
权利人:UNIV CALIFORNIA
摘要:In order to facilitate the approval and commercialization of silicasome drug delivery systems (e.g. irinotecan silicasomes) it is necessary to scale up synthesis of the drug-loaded silicasomes. In this regard, it was discovered that the synthesis protocols used for laboratory synthesis of drug-loaded silicasomes (e.g., 500 mg/batch) do not scale to large scale silicasome production, because the resulting products were too heterogeneous for use as pharmaceuticals. Accordingly, new methods are provided herein that effectively afford the large-scale production of mesoporous silica nanoparticles (MSNPs) and lipid bilayer coated MSNPs (silicasomes).

专利号:US-7714063-B2
优先权日:2007-11-15
标 题 :Solid support for Fmoc-solid phase synthesis of peptides
发明人：SRIVASTAVA KRIPA SHANKER; DAVIS MATTHEW RYAN
权利人:MALLINCKRODT INC
摘要:The present invention provides compositions and processes for the solid phase synthesis of polypeptides. In particular, the present invention provides solid supports and processes for preparing solid supports for the synthesis of polypeptides.

专利号:US-12351573-B2
优先权日:2019-05-09
标 题:Compounds for use in synthesis of peptidomimetics
发明人：AL-ABED YOUSEF; CHENG KAI FAN
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Synthesis of O-benzotriazole and O-imidazole synthons are described. Uses of synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the synthons and uses of azapeptides and other peptidomimetics are also described.

专利号:US-2023159450-A1
优先权日:2020-05-08
标 题 :Dimers for use in synthesis of peptidomimetics
发明人：AL-ABED YOUSEF; ALTITI AHMAD
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Dimers for use in synthesis of peptidomimetics are described. Uses of dimers as synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the dimers and uses of azapeptides and other peptidomimetics are also described.

专利号:EP-0443532-B1
优先权日:1990-02-20
标题:Temporary minimal protection synthesis of LH-RH analogs
发明人：NESTOR JOHN J JR; MCCLURE NATALIE L
权利人:SYNTEX INC
摘要:A solid phase synthesis of LH-RH analogs in which the amino acids serine and histidine, if present, are side chain protected during the synthesis with groups labile to selected alpha -amino or deprotecting agents.

专利号:US-5212288-A
优先权日:1990-02-20
标 题:Temporary minimal protection synthesis of serine-containing polypeptides
发明人：NESTOR JR JOHN J; MCCLURE NATALIE L; ARZENO HUMBERTO
权利人:SYNTEX INC
摘要:In a process for the solid phase synthesis of a polypeptide containing at least one serine residue, the improvement comprising temporarily protecting the side chain of the serine residue with a protecting group which is removed immediately following the addition of the serine to the peptide chain.