CAS: 497-06-3; But-3-Ene-1,2-Diol

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CAS号930-22-3 3,4-环氧-1-丁烯 | CAS号6117-80-2 顺-2-丁烯-1,4-二醇 | CAS号821-11-4 反-2-丁烯-1,4-二醇 | CAS号671-56-7 1-chloro-2-hydr... | CAS号6974-12-5 1,4-二溴丁烯-2 | CAS号106-99-0 丁二烯 | CAS号110-57-6 反-1,4-二氯-2-丁烯 | CAS号821-06-7 反式-1,4-二溴-2-丁烯 | CAS号590-19-2 1,2-丁二烯 | CAS号4427-96-7 乙烯基碳酸乙烯酯 | CAS号18085-02-4 3,4-双乙酸基-1丁烯 | CAS号5077-67-8 1-羟基-2-丁酮 | CAS号52642-66-7 1-hydroxybut-3-... | CAS号4437-51-8 3,4-己二酮 | CAS号123-38-6 丙醛 | CAS号123-73-9 2-丁烯醛 | CAS号149-32-6 赤藓糖醇 | CAS号22554-74-1 顺-3,4-二羟基呋喃

📜(+/-)-1-(4-Methoxybenzyloxy)But-3-En-2-Ol置于三氟乙酸体系中,用 二氯甲烷 作为反应溶剂,化学反应 1.0H,反应生成 丁烯二醇
参考文献:酶介导的带有不饱和取代基的1,2-二醇单甲苯磺酸酯衍生物的对映体选择性水解
标题:酶介导的带有不饱和取代基的1,2-二醇单甲苯磺酸酯衍生物的对映体选择性水解
摘要:我们已经成功地通过酶水解容易地制备了带有不饱和取代基的光学活性的1,2-二醇单甲苯磺酸酯.脂肪酶ps快速催化具有双键的2-乙酰氧基丁-3-烯基甲苯磺酸酯和具有三键的2-乙酰氧基丁-3-炔基甲苯磺酸酯的水解,具有出色的对映选择性,可提供相应的旋光化合物.该反应也适用于在末端具有双键的较长链的乙酸酯.为了证明该方法的适用性,已从外消旋的2-乙酰氧基戊-4-烯基甲苯磺酸酯中分几步合成了对映体纯的(R)-马苏阿内酯,一种天然椰子香精.此外,该酶可以识别烯烃的立体化学,而(z)-烯基结构比(e)-异构体更适合于对映选择性水解.
DOI:10.1016/j.Tet.2018.05.087

专利信息

专利号:US-5306638-A
优先权日:1992-03-20
标题 :Amine additive assisted enzymatic esterification of 1,2-diol monosulfonates
发明人：BOAZ NEIL W
权利人:EASTMAN KODAK CO
摘要:A process has been developed for the enzymatic esterification of 1,2-diol monosulfonates comprising contacting an ester; a 1,2-diol monosulfonate; an enzyme derived from a microorganism or animal organ which has stereoselective activity to asymmetrically esterify said 1,2-diol monosulfonate; in the presence of a nonhydroxylic organic solvent and an amine additive of the general formula R32R4N, wherein R3 may be the same or different and is selected from hydrogen or a straight or branched C1-C20 alkyl; and R4 is a straight or branched C1-C20 alkyl; or an unsubstituted or substituted C3-C20 aryl or heteroaryl group (with saisd substituent selected from C1-C4 alkyl, halogen, or C1-C4 alkoxy, and said hetero atom selected from nitrogen, sulfur, or oxygen); to produce a mixture of enantiomerically enriched unreacted 1,2-diol monosulfonate and the corresponding antipodal enantiomerically enriched ester. The resulting enantiomerically enriched products are useful chemical intermediates that may be employed in the synthesis of pharmaceutical and agricultural chemicals.

专利号:WO-9746543-A1
优先权日:1996-05-31
标题:Acetyl derivatives of thiazoles and analogues
发明人：PYNE STEPHEN GEOFFREY; UNG ALISON THAVARY
权利人:UNIV WOLLONGONG; PYNE STEPHEN GEOFFREY; UNG ALISON THAVARY
摘要:The present invention is directed to compounds useful in the treatment of autoimmune diseases and inflammatory diseases of general formula (I) wherein R1 is alkyl, alkenyl or alkynyl having from 1 to 6 carbons, phenyl, benzyl or phenethyl; R2 is H, C1 to C5 alkyl which can optionally be partially hydroxylated or the group (a) wherein n is from 0 to 4; and X, Y and Z are independently CH, N, NH, O or S, or a pharmaceutically acceptable ester or acid addition salt thereof, or a stereoisomer or a geometric isomer thereof, with the proviso that at least one of X, Y or Z is CH, that one and only one of X, Y and Z is NH, O or S and further that when Y is N or NH then Z is not N or NH. The present invention is also concerned with processes for the synthesis of the compounds and with methods of use of the compounds.

专利号:US-4231941-A
优先权日:1979-06-25
标题:Synthesis of 2,5-dihydrofuran
发明人：DRURY ROBERT F
权利人:DU PONT
摘要:Improved process for preparing 2,5-dihydrofuran by the dehydration of 1-butene-3,4-diol in the presence of a soluble mercury salt as catalyst in a dissociating solvent at a neutral or acidic pH at an elevated temperature, the improvement characterized in that the dehydration is carried out at a pH of 4 to 7 at 80 DEG -120 DEG C. in the presence of solid mercuric oxide.

专利号:US-3795682-A
优先权日:1970-07-27
标题 :Synthesis of cyclic ketals
发明人：DELAVARENNE S
权利人:UNION CARBIDE CORP
摘要:CYCLIC KETALS ARE PRODUCED BY CONTACTING A DEHYDRATING AGENT WITH A COMPOUND OF THE FORMULA: HO-C(-R2)(-R3)-X1-R1-X2H WHEREIN X1 REPRESENTS OXY, THIO, OR NITRILO, WHEREIN X2 REPRESENTS OXY, THIO, OR IMINO, PROVIDED THAT AT LEAST ONE OF X1 AND X2 REPRESENTS OXY, WHEREIN R1 REPRESENTS AN ALKYLENE GROUP OF FROM 2 TO 4 CARBON ATOMS OR A 2BUTYLENE GROUP, AND WHEREIN R2 AND R3 INDIVIDUALLY REPRESENT HALOGENATED ALKYL GROUPS THE ALPHA CARBON ATOMS BEING FLUORO, CHLORO, OR BROMO. THE CYCLIC KETALS PROGROUP, THE REMAINDER OF THE HALO GROUPS ON THE ALKYL BEING FLUORO, CHLORO, OR BROMO. THE CYCLIC KETALS PRODUCED ARE REPRESENTED BY THE FORMULA: R2-C(-R3)<(-O-R4-X1-) WHEREIN X1, R2, AND R3 ARE AS DEFINED ABOVE, AND WHEREIN R4 REPRESENTS ALKYLENE OF 2 TO 4 CARBON ATOMS OR SUBSTITUTED ALKYLENE. THE DEHYDRATING AGENTS EMPLOYED INCLUDE CARBODIIMIDES AND ALPHA-AMINOACETYLENES. THE PROCCESS OF THE INVENTION IS USEFUL FOR THE PREPARATION OF 1,3DIOXOLANES, 1,3 - DIOXANES, 1,3 - DIOXEPANES, AND THEIR ANALOGUES WHEREIN ONE OF THE OXYGEN ATOMS IN THE HETEROCYCLIC RING IS REPLACED BY EITHER A SULFUR ATOM OR NITRILO GROUP.

专利号:US-6716998-B2
优先权日:2001-10-05
标 题:Process for synthesis of 2-yl chroman derivatives
发明人：GROSS JONATHAN L
权利人:WYETH CORP
摘要:This invention provides a process for the stereospecific preparation of 2-yl-chroman and -chromene derivatives of the formula:These compounds are useful for the preparation of optically active 2-aminomethyl- and 2-azaheterocyclylmethyl-chromans.

专利号:US-2010298504-A1
优先权日:2007-09-19
标题 :Amphiphilic polymer and processes of forming the same
发明人：Janczewski Dominik; TOMCZAK NIKODEM; KHIN YIN WIN; HAN MINGYONG; VANCSO JULIUS
权利人:AGENCY SCIENCE TECH & RES
摘要:Disclosed are an amphiphilic polymer, its synthesis and uses thereof. The polymer has a hydrocarbon backbone with —COOH side groups. It further has first aliphatic moieties with a main chain of about 3 to about 20 carbon atoms and 0 to about 3 heteroatoms, and second aliphatic moieties that have a main chain of about 3 to about 80 carbon atoms and about 2 to about 40 heteroatoms. The second aliphatic moieties have a copolymerisable group. In the synthesis a maleic anhydride polymer of formula (I) where n is an integer from about 10 to about 10000 and R1 is H or methyl, is reacted with a monofunctional compound with an alkyl chain of about 3 to about 20 carbon atoms and 0 to about 2 heteroatoms, and with an at least bifunctional compound with an alkyl chain of about 3 to about 80 carbon atoms and 0 to about 40 heteroatoms. The functional group of the monofunctional compound and one functional group of the at least bifunctional compound can form a linkage with an anhydride. Another functional group of the at least bifunctional compound, which is not allowed to react with the maleic anhydride polymer, is copolymerisable.