CAS: 4870-65-9; A-Bromophenylacetic Acid

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2-氨基-2-苯基乙酸置于氢溴酸,Sodium Nitrite体系中,用 水 作为反应溶剂,化学反应 2.5H,反应生成 Alpha-溴苯乙酸
参考文献:通过 Brønsted 碱催化迈克尔反应对四取代的立体碳的对映选择性构建:α'-羟基烯酮作为关键的烯酸酯等效物
标题:通过 Brønsted 碱催化迈克尔反应对四取代的立体碳的对映选择性构建:α'-羟基烯酮作为关键的烯酸酯等效物
摘要:催化和不对称迈克尔反应构成了合成中构建新 Cc 键的非常强大的工具,但大多数声称具有高选择性的报告仅限于亲核/亲电化合物类型的某些特定组合,只有少数成功的方法处理了全碳四元立体中心.基于手性双功能 Brønsted 碱 (Bb) 催化和使用 α'-氧烯酮作为使迈克尔受体具有矛盾的 H 键受体/供体特征,这是一种尚未报道的双齿烯酸设计元素,为解决这一差距做出了贡献.等价物.发现之前证明具有挑战性的一系列烯醇化羰基化合物(即 α-取代的 2-羟吲哚,氰基酯,恶唑酮,噻唑酮,和 Azlactones) 到 α'-氧烯酮可以在标准 Bb 催化剂存在下以高非对映选择性和对映选择性提供相应的四取代碳立体中心.实验表明,α'-氧基酮部分在上述实现中起着关键作用,因为在相同条件下进行平行反应,但使用母体 α,β-不饱和酮或酯进行缓慢和/或立体选择性差.对加合物中的酮醇部分进行一系列简单的化学操作可以在非常
DOI:10.1021/ja510603W

专利信息

专利号:US-6376667-B1
优先权日:1997-11-26
标 题 :Solid phase synthesis of heterocycles
发明人：CASTELHANO ARLINDO L; SHAO HUI
权利人:OSI PHARM INC
摘要:Methods and compounds for the synthesis of heterocycles, including pyrimidine-2,4-diones, are disclosed. Also disclosed are solid supports useful for solid phase synthesis, and methods for making the solid supports.

专利号:US-6469133-B2
优先权日:1999-12-13
标题 :Process for the preparation of polymers of dimeric cyclic esters
发明人：BAKER GREGORY L; SMITH III MILTON R
权利人:UNIV MICHIGAN STATE
摘要:The present invention provides a process for the direct synthesis of high melting polymers made from dimeric cyclic esters. In particular, the present invention provides a process for synthesis of polylactic acid (PLA) from racemic materials such as racemic lactide and polymandelide from mandelide. The process further provides racemic metal organic ligand catalysts such as racemic salbinap that catalyzes the polymerization of racemic dimeric cyclic ester monomers to a polylactide stereocomplex. Polymandelide and mixed dimeric cyclic esters are also prepared in the presence of low amounts of water.

专利号:US-9546161-B2
优先权日:2001-07-16
标题:Synthesis of UDP-glucose: N-acylsphingosine glucosyl transferase inhibitors
发明人：HIRTH BRADFORD H; SIEGEL CRAIG
权利人:GENZYME CORP
摘要:Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.

专利号:WO-8911473-A1
优先权日:1988-05-27
标 题:Process for the synthesis of o-substituted oxime compounds
发明人：CHEMPOLIL THOMAS MATHEW
权利人:ALLIED SIGNAL INC
摘要:A novel process for the production of O-substituted oximes is disclosed. The process involves reacting an oxime with an alkali-metal hydroxide optionally in a solvent which forms an azeotrope with water to form a mixture of the alkali metal salt of the oxime and water, removing all or a portion of the water by distilling the mixture azeotropically and reacting the distilled mixture with an alpha halo carboxylic acid.

专利号:WO-2014138989-A1
优先权日:2013-03-15
标 题 :Method and intermediates for the synthesis of hydroxamic acid compounds
发明人：VAISBURG ARKADII; RAEPPEL FRANCK; ROY SIMON; ZHOU NANCY Z
权利人:METHYLGENE INC
摘要:Methods are disclosed for making a compound of formula and intermediates therefor, where R is aryl or heteroaryl, and L is C3_8alkylene, wherein each of R, L, and the illustrated phenyl group are independently optionally substituted with one or more substituents selected from the group consisting of C].6alkyl, Ci.6alkoxy, CF3, CHF2, CH2F, fluoro, and cyano, which methods can avoid the use of iodo-phenyl esters, or aryl alkynes, or both, or, in which synthetic methods at least one of the intermediates is a solid at room temperature that does not require purification by chromatography.

专利号:WO-9967219-A1
优先权日:1998-06-22
标 题:Compounds for inhibiting beta-amyloid peptide release and/or its synthesis
发明人：AUDIA JAMES E; PORTER WARREN J; THOMPSON RICHARD C; WILKIE STEPHEN C; STACK DOUGLAS R; SHI QING
权利人:ELAN PHARM INC; LILLY CO ELI; AUDIA JAMES E; PORTER WARREN J; THOMPSON RICHARD C; WILKIE STEPHEN C; STACK DOUGLAS R; SHI QING
摘要:Compounds of formula (I), wherein W is a cyclic group of the type (2); (3); Y is represented by the formula (II); these compounds inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.