CAS: 471-09-0; (R)-2-Amino-3-((4-Hydroxy-2-Methylbutan-2-yl)Thio)Propanoic Acid

该化合物是含有硫磺的氨基酸衍生物,该化合物具有硅基骨的特征,其特点是存在硫醇(-SH)组,有助于其反应和潜在的生物活动.添加一个4-Hydrox-2-甲基丁基副链会增强它的体力,并可能影响它与生物系统的互动.该化合物对生化研究很感兴趣,因为它在细胞过程(包括抗氧化活动和蛋白合成)中具有潜在作用.它也可能参与各种代谢途径,特别是涉及硫化合物的代谢途径.在侧链中存在氢氧基组会促进氢的结合,影响溶性与再活性.

结构式图片

MSDS等安全信息

    上下游产品

    CAS号2568-33-4 3-甲基-1,3-丁二醇 | CAS号52-90-4 L-半胱氨酸 | CAS号879207-98-4 N-B°C-L-丝氨酸 | CAS号107-86-8 异戊烯醛 | CAS号20887-95-0 B°C-L-半胱氨酸

    合成工艺路线路线简述

    • 合成目标产物 L-Felinine 主要起始原料 N-Boc-L-Felinine
    • (文献来源)合成步骤主要原料 N-Boc-L-Felinine
    📜S-(4-羟基-2-甲基-2-丁炔基)-N-{[(2-甲基-2-丙基)氧基]羰基}-L-半胱氨酸置于盐酸体系中,用750 Mg的收率获得产物猫尿胺酸
    参考文献:Volatile Organic Sulfur-Containing Constituents In Poncirus Trifoliata (L.) Raf. (Rutaceae)
    标题:Volatile Organic Sulfur-Containing Constituents In Poncirus Trifoliata (L.) Raf. (Rutaceae)
    摘要:During Our Screening Of Plant Materials To Find New Natural Fragrance And Flavor Ingredients,We Discovered Two Series Of 3-Sulfanylalkyl Alkanoates In A Peel Extract Of Fruits Of Wild-Growing Poncirus Trifoliata (L.) Raf. (Rutaceae),A Species Closely Related To Citrus. The Two Series Belong To Alkanoates Of 3-Methyl-3-Sulfanylbutan-1-Ol And 3-Sulfanylhexan-1-Ol,Respectively,And Thus Are Members Of A Family Of Natural Molecules Having In Common A 1,3-Positioned O,S Moiety. The Alkanoate Residues Comprise All Even-Numbered Saturated Fatty Acids From C2 (Acetate) To C18 (octadecanoate). Among The 20 Sulfur-Containing Compounds Identified,14 Are Described For The First Time As Naturally occurring In A Botanical Species. Several Cysteine-S-Conjugates Were Synthesized As Hypothetical Precursors Of The New Volatile Sulfur-Containing Constituents,Where After S-(3-Hydroxy-1,1-Dimethylpropyl)-L-Cysteine,S-[3-(Acetyloxy)-1,1-Dimethylpropyl]-L-Cysteine,And S-[1-(2-Hydroxyethyl)Butyl]-L-Cysteine Were Identified In The Fruit Peel. No Cysteine-S-Conjugates Were Detected In The Fruit Juice.
    DOI:10.1021/jf063453H

    海关参考信息

    专利信息


    专利号:US-5627283-A
    优先权日:1991-05-11
    标题:Amidinophenylalanine derivatives, a process for the preparation thereof, use thereof and agents containing these as anticoagulants
    发明人:STUEBER WERNER DR; DICKNEITE GERHARD DR; KOSCHINSKY RAINER
    权利人:BEHRINGWERKE AG
    摘要:Amidinophenylalanine derivatives of the formula I (I) the synthesis of these compounds, the use thereof and pharmaceutical agents which contain these compounds are described.

    专利号:CN-108611384-B
    优先权日:2012-08-20
    标题:Methods for large-scale enzymatic synthesis of oligosaccharides

    专利号:CN-108504703-B
    优先权日:2012-08-20
    标题:Process for large scale enzymatic synthesis of oligosaccharides

    专利号:CN-108504702-B
    优先权日:2012-08-20
    标题:Methods for large-scale enzymatic synthesis of oligosaccharides

    专利号:CN-108588151-B
    优先权日:2012-08-20
    标 题 :Process for large scale enzymatic synthesis of oligosaccharides

    专利号:CN-108546643-B
    优先权日:2012-08-20
    标 题:Methods for large-scale enzymatic synthesis of oligosaccharides

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Miyazaki M, Miyazaki T, Nishimura T, Hojo W, Yamashita T. The Chemical Basis of Species, Sex, and Individual Recognition Using Feces in the Domestic Cat. J Chem Ecol. 2018 Apr;44(4):364-373. doi: 10.1007/s10886-018-0951-3. Epub 2018 Apr 10. doi: 10.1016/j.jchromb.2017.11.006. Epub 2017 Nov 6. doi: 10.1371/journal.pone.0168144. eCollection 2016.
    4: Cibaka ML, Gros J, Nizet S, Collin S. Quantitation of selected terpenoids and mercaptans in the dual-purpose hop varieties Amarillo, Citra, Hallertau Blanc, Mosaic, and Sorachi Ace. J Agric Food Chem. 2015 Mar 25;63(11):3022-30. doi: 10.1021/jf5058556. Epub 2015 Mar 17. doi: 10.2527/jas.2013-7510. Chapter 14. doi: 10.1134/S0012496613060057. Epub 2014 Jan 3. doi: 10.1111/jpn.12097. Epub 2013 Jul 2. doi: 10.1371/journal.pntd.0001389. Epub 2011 Nov 8.
    10: Li G, Janecka JE, Murphy WJ. Accelerated evolution of CES7, a gene encoding a novel major urinary protein in the cat family. Mol Biol Evol. 2011 Feb;28(2):911-20. doi: 10.1093/molbev/msq281. Epub 2010 Oct 21. doi: 10.1016/j.jchromb.2008.04.001. Epub 2008 Apr 8. doi: 10.1017/S0007114508945165. Epub 2008 Mar 17. doi: 10.1111/j.1439-0396.2007.00710.x. Epub 2007 Sep 29. Epub 2007 Aug 4. Epub 2006 Jul 31. Epub 2004 Jun 4. doi: 10.1093/jn/134.8.2114S.

    合成参考文献


    参考文献:10.1007/s10886-019-01083-3
    摘要:Suzuki C, Miyazaki T, Yamashita T, Miyazaki M. GC × GC-MS-Based Volatile Profiling of Male Domestic Cat Urine and the Olfactory Abilities of Cats to Discriminate Temporal Changes and Individual Differences in Urine. Journal of Chemical Ecology. 2019 Jun 29;45(7):579–87. doi: 10.1007/s10886-019-01083-3.
    参考文献:10.1007/s00726-004-0095-3
    摘要:Rutherfurd SM, Zhang F, Harding DR, Woolhouse AD, Hendriks WH. Use of capillary (zone) electrophoresis for determining felinine and it's application to investigate the stability of felinine. Amino Acids. 2004 Aug;27(1):49–55. doi: 10.1007/s00726-004-0095-3.
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