CAS: 34784-05-9; 6-Bromoisoquinoline

相似化合物

58794-09-5 34784-04-8 63927-22-0

上下游产品

6-bromo-1H-indene dimethyl(p-bromobenzylidene)aminoacetal 4-bromo-benzaldehyde 2,2-dimethoxyethylamine isoquinoline6-4-(dibutylamino)phenylisoquinoline isoquinoline-6-carboxylic acid methyl ester 6-bromoisoquinoline nitrogen oxide tert-butyl ester[2-(5-isoquinolin-6-yl-pyridin-3-yloxy)-1-phenyl-ethyl]-carbamic acid tert-butyl ester

4-Bromo-2-(2-Oxoethyl)Benzaldehyde置于ammonium Hydroxide体系中,用 甲醇,二氯甲烷 作为反应溶剂,化学反应 24.0H,以4.8 G的收率获得产物6-溴异喹啉
参考文献:三组分反应合成吲哚-二氢异喹啉磺酰脲
标题:三组分反应合成吲哚-二氢异喹啉磺酰脲
摘要:摘要 使氨磺酰氯活化的异喹啉在3组分反应中与吲哚反应,反应生成二氢异喹啉衍生物的文库.使用差异保护基团策略,可以进一步衍生产品.还描述了使用几种不同方法合成异喹啉原料. 使氨磺酰氯活化的异喹啉在3组分反应中与吲哚反应,反应生成二氢异喹啉衍生物的文库.使用差异保护基团策略,可以进一步衍生产品.还描述了使用几种不同方法合成异喹啉原料.
DOI:10.1055/s-0037-1610223

专利信息

专利号:WO-2011106986-A1
优先权日:2010-03-02
标题:Inhibitors of hepatitis c virus ns5b polymerase
发明人：MCCOMAS CASEY CAMERON; LIVERTON NIGEL J; SOLL RICHARD; LI PENG; PENG XUANJIA; WU HAO
权利人:MERCK SHARP & DOHME; MCCOMAS CASEY CAMERON; LIVERTON NIGEL J; SOLL RICHARD; LI PENG; PENG XUANJIA; WU HAO
摘要:Compounds of formula (I) that are used as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and /or viral production in a cell-based system. Wherein Z, R 30 , R 40 , R 50 and R 60 of compounds of formula (I) are herein defined as in the description.

专利号:US-2012328569-A1
优先权日:2010-03-02
标题:Inhibitors of hepatitis c virus ns5b polymerase
发明人：MCCOMAS CASEY CAMERON; LIVERTON NIGEL J; SOLL RICHARD; LI PENG; PENG XUANJIA; WU HAO; NARJES FRANK; HABERMANN JOERG; KOCH UWE; LIU SHILAN
权利人:MCCOMAS CASEY CAMERON; LIVERTON NIGEL J; SOLL RICHARD; LI PENG; PENG XUANJIA; WU HAO; NARJES FRANK; HABERMANN JOERG; KOCH UWE; LIU SHILAN
摘要:Disclosed are compounds of formula (I) that are used as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-10125226-B2
优先权日:2013-06-05
标 题 :Scale-up process of bifunctionalized triblock copolymers with secondary and tertiary amines, with application in dewatering and desalting of heavy crude oils
发明人：FLORES SANDOVAL CESAR ANDRES; FLORES OROPEZA EUGENIO ALEJANDRO; LOPEZ ORTEGA ALFONSO; HERNANDEZ CORTEZ JOSE GONZALO; ESTRADA BUENDIA ARISTEO; CASTRO SOTELO LAURA VERONICA; REYES MARTINEZ REYNA; ALVAREZ RAMIREZ FERNANDO; ESTRADA MARTINEZ ARQUIMEDES; VAZQUEZ MORENO FLAVIO SALVADOR
权利人:MEXICANO INST PETROL
摘要:A chemical synthesis process is provided for the functionalization of monodispersed triblock copolymer (POEw-POPy-POEw) with secondary or tertiary amines at a semi-industrial level in glass reactors having a capacity between 1 L and 100 L. The process includes two stages where the first stage uses an alkylsulfonyl or arylsulfonyl chloride to obtain better leaving groups, and the second stage is the nucleophilic substitution with secondary or tertiary amines, to obtain the bifunctionalized triblock copolymers. The main advantage for this process is to reduce the quantity of unitary process done in each stage, the optimization of reaction times, and the stoichiometric relationships.

专利号:AU-2022253019-A1
优先权日:2021-04-09
标题:Synthesis of rapamycin analog compounds

专利号:TW-202304863-A
优先权日:2021-04-09
标题:Synthesis of rapamycin analog compounds

专利号:US-7999090-B2
优先权日:2000-07-07
标 题:Fungal cell wall synthesis gene
发明人：TSUKAHARA KAPPEI; HATA KATSURA; SAGANE KOJI; NAKAMOTO KAZUTAKA; TSUCHIYA MAMIKO; WATANABE NAOAKI; OHBA FUMINORI; TSUKADA ITARU; UEDA NORIHIRO; TANAKA KEIGO; KAI JUNKO
权利人:EISAI R&D MAN CO LTD
摘要:The present invention provides isolated DNA encoding a GWT1 protein having activity to confer resistance of a fungus against a compound of formula Ia, and wherein a defect of a function of the GWT1 protein leads to a decrease in the amount of a glycosylphosphatidylinositol (GPI)-anchored protein in the cell wall of a fungus.