专利号:US-4226778-A 优先权日:1978-04-14 标 题:Process for the manufacture of alkylene carbonates 发明人:VENTURELLO CARLO; D ALOISIO RINO 权利人:MONTEDISON SPA 摘要:A new process is disclosed for the synthesis of alkylene carbonates having from 2 to 4 carbon atoms in the chain, starting from a corresponding halohydrin having the formula: wherein Ra, Rb, Rc and Rd are independently hydrogen or alkyl, aryl, alkylaryl or arylalkyl radicals and where X is a halogen, characterized in that said halohydrin is reacted with a bicarbonate of a quaternary -onium compound, where '-onium' means ammonium, phosphonium, arsonium or stibonium, preferably using an organic solvent as diluent and operating in the presence of carbon dioxide.
专利号:US-8779194-B2 优先权日:2006-10-27 标 题 :Carbamoylation of amines, thiophenols, mercaptanes and phenols employing organic azides 发明人:YAGODKIN ANDREY; AZHAYEV ALEX 权利人:YAGODKIN ANDREY; AZHAYEV ALEX; METKINEN CHEMISTRY OY 摘要:The present invention relates to carbamoylation of amines, mercaptanes, thiophenols and phenols employing organic azides. More specifically, the invention relates to a method for generating urea derivatives, thiocarbamate derivatives and carbamate derivatives, and is based on the intermediate formation of isocyanate, starting from an organic azide. The reaction as described is useful in applications for modified nucleoside synthesis, oligonucleotide synthesis, as well as modification, labeling and conjugation of polymers and biomolecules.
专利号:US-2008214386-A1 优先权日:2004-03-01 标题:Catalyst for Cyclic Carbonate Synthesis 发明人:TAKAHASHI TOSHIKAZU; WATAHIKI TSUTOMU; YASUDA HIROYUKI; SAKAKURA TOSHIYASU 权利人:TAKAHASHI TOSHIKAZU; WATAHIKI TSUTOMU; YASUDA HIROYUKI; SAKAKURA TOSHIYASU 摘要:Provided are a solid catalyst which gives a cyclic carbonate at a high yield and a high selectivity, which is stable and which may be readily separated after reaction; and a method of industrially advantageous, inexpensive and safe production of a cyclic carbonate by the use of the catalyst. The catalyst contains an inorganic solid substance having a surface modified with an ionic substance containing a Group 15 element; or contains an ionic substance containing a Group 15 element, and an inorganic solid substance. The modifying group for surface modification of an inorganic solid substance is an ionic substance containing a Group 15 element. The ionic substance containing a Group 15 element is at least one substance selected from organic phosphonium salts, organic ammonium salts, organic arsonium salts and organic antimonium salts.
专利号:US-9051292-B2 优先权日:2009-08-11 标题 :Sultone compound derivatives substituted by nucleophiles, in particular radionuclides, and use thereof for marking macromolecules 发明人:BOUTEILLER CEDRIC 权利人:BOUTEILLER CEDRIC; ADVANCED ACCELERATOR APPLIC 摘要:The invention relates to polysultone derivatives used as precursors to radiolabelled macromolecules usable for medicine and in nuclear imaging. The aim of the invention is to provide novel prosthetic compounds or groupings, the synthesis of which is straightforward, easy and automatable, enabling access to economical and effective radiolabelled macromolecules. The aim is achieved by the invention, which involves compounds of formula 10 or 11. Said double-sultone derivatives are produced by opening the sultone rings using a nucleophile radical R i which may be a radionucleide R* for one of the sultone rings and an active radical peptide R a for the other sultone ring. The invention also relates to the method for producing the abovementioned compounds, as well as to the drugs or diagnosis products that the latter are capable of forming.
专利号:WO-2011069309-A1 优先权日:2009-12-08 标 题 :Di-quaternary ammonium base compound and its preparation method and use 发明人:DING KEHONG; SHI XUEFANG; CHENG XIAOXI; WANG QIUPING; GU KEJUN; XU JINLAI 权利人:JIANGSU YANGNONG CHEMICAL GROUP CO LTD; YANGZHOU FUYUAN CHEMICAL TECHNOLOGY CO LTD; DING KEHONG; SHI XUEFANG; CHENG XIAOXI; WANG QIUPING; GU KEJUN; XU JINLAI 摘要:A di-quaternary ammonium base compound of Formula (I) is provided wherein R1 and R2 are independently C1-C18 hydrocarbyl; R3, R4, R5, and R6 are independently C1-C6 straight-chained or branch-chained hydrocarbyl; and R7 is C2-C6 alkylene or alkoxyl substituted C2-C6 alkylene. The synthesis method of the di-quaternary ammonium base compound comprises preparing di-quaternary ammonium salt and obtaining di-quaternary ammonium base through ion-exchange. The di-quaternary ammonium base compound can be used as condensation catalyst for synthesizing rubber antioxidant intermediate 4-amino diphenylamine through condensation of nitrobenzene with aniline followed by hydrogenation. Compared with the normal quaternary ammonium base tetramethyl ammonium hydroxide, the di-quaternary ammonium base compound has convenient material source, low cost, simple preparation process, and good heat stability.
专利号:CN-107417539-B 优先权日:2017-05-16 标题:A kind of method of tank reactor series connection tubular reactor synthesis tetramethyl ammonium hydrogen carbonate
参考文献:10.1007/978-1-61779-040-9_11 摘要:Liu W, Iliuk A, Tao A, Ding S. Identifying protein complexes by affinity purification and mass spectrometry analysis in the rice blast fungus. Methods Mol Biol. 2011;722():157–66. doi: 10.1007/978-1-61779-040-9_11.