CAS: 288385-88-6; 4-Fluoro-5-Hydroxy-2-Methylindole

上下游产品

2-甲基-4-氟-5-甲氧基-1H-吲哚 2-Methyl-4-Fluoro-5-Methoxy-1H-Indole 288385-93-3

1-(3-(苄氧基)-2-氟-6-硝基苯基)-2-丙酮置于钯 乙酸乙酯,碳酸氢钠,Brine体系中,用 乙醇,溶剂黄146 用作溶剂,化学反应 2.0H,以to Give 4-Fluoro-5-Hydroxy-2-Methylindole的收率获得4-氟-5-羟基-2-甲基吲哚
参考文献:Quinazoline Compounds
标题:Quinazoline Compounds
摘要:该发明涉及式(I)化合物及其盐,其中环c,Z,M,N,R1和r2在此处定义;它们在制造用于在恒温动物中产生抗血管生成和/或血管渗透性降低效应的药物中的使用;制备此类化合物的过程;用于此类过程的中间体;制备此类中间体的过程;含有式(I)化合物或其药学上可接受的盐的药物组合物,以及通过给予式(I)化合物或其药学上可接受的盐来治疗涉及血管生成的疾病状态的方法.

专利信息

专利号:US-2008108611-A1
优先权日:2006-01-19
标 题 :Substituted thienopyrimidine kinase inhibitors
发明人：BATTISTA KATHLEEN A; BIGNAN GILLES C; CONNOLLY PETER J; EMANUEL STUART L; HAYDEN STUART; JOHNSON SIGMOND G; LIN RONGHUI; MIDDLETON STEVEN A; PANDEY NIRANJAN B; POWELL MARK T
权利人:BATTISTA KATHLEEN A; BIGNAN GILLES C; CONNOLLY PETER J; EMANUEL STUART L; HAYDEN STUART; JOHNSON SIGMOND G; LIN RONGHUI; MIDDLETON STEVEN A; PANDEY NIRANJAN B; POWELL MARK T
摘要:The present invention is directed to thienopyrimidine compounds of formula (I): n n n n n n n n n n and forms thereof, their synthesis and use for treating, preventing or ameliorating a chronic or acute protein kinase mediated disease, disorder or condition.

专利号:US-8013153-B2
优先权日:2006-03-23
标 题:Substituted pyrimidine kinase inhibitors
发明人：BUTLER JEANNENE; CONNOLLY PETER J; FUENTES-PESQUERA ANGEL R; GREENBERGER LEE M; HUANG SHENLIN; LAMONTAGNE JR KENNETH R; LI RONGHUA; XU GUOZHANG
权利人:JANSSEN PHARMACEUTICA NV
摘要:The present invention is directed to substituted pyrimidine compounds of formula (I): n nand forms thereof, their synthesis and use for treating a chronic or acute protein kinase mediated disease, disorder or condition.