CAS: 21732-17-2; Tetrazol-1-Yl-Acetic Acid

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CAS号15284-25-0 2-(tetrazol-1-y... | CAS号122-51-0 原甲酸三乙酯 | CAS号56-40-6 甘氨酸 | CAS号957-68-6 7-氨基头孢烷酸 | CAS号55633-19-7 四氮唑-1-乙酸甲酯 | CAS号22252-43-3 7-氨基去乙酰氧基头孢烷酸 | CAS号30246-33-4 7-氨基-3-[(2-甲基-1... | CAS号26240-90-4 ethyl 2-(tetraz... | CAS号79673-92-0 [2-(tetrazol-1-... | CAS号55633-19-7 四氮唑-1-乙酸甲酯

(5-氨基-1H-四唑-1-基)乙酸置于硫酸,次磷酸体系中,用 水 用作溶剂,化学反应 5.0H,以78.2%的收率获得四氮唑乙酸
参考文献:一种1-乙酸四氮唑的制备方法
标题:一种1-乙酸四氮唑的制备方法
摘要:本发明涉及有机合成领域,公开了一种1‑乙酸四氮唑的制备方法,包括:1)以氨基胍碳酸盐为原料,用酸溶液调至酸性后,降温后滴加亚硝酸钠水溶液,然后调ph为碱性,回流关环生成5‑氨基四氮唑;2)将5‑氨基四氮唑与氯乙酸在碱性条件下反应合成1‑乙酸‑5‑氨基四氮唑;3)最后用还原剂进行还原脱除氨基,得到1‑乙酸四氮唑.本发明方法相对于现有技术来说更加安全,环保,并且所得产物收率,纯度高.

专利信息

专利号:US-7138526-B1
优先权日:1999-06-15
标 题 :Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives
发明人：HERPIN TIMOTHY F; MORTON GEORGE C; SALVINO JOSEPH M
权利人:AVENTIS PHARMA INC
摘要:A method for the solid phase synthesis of N,N-disubstituted diazacycloalkylcarboxy derivatives of general formula (I) and (II) is claimed. Examples include piperazine-2-carboxamide. The method is applicable to the synthesis or large combinatorial libraries

专利号:US-9006421-B2
优先权日:2013-03-14
标题 :Cephalosporin compositions and methods of manufacture
发明人：LAI JAN-JI; PATHARE PRADIP M; KOLLA LAXMA; SORET ADRIEN F
权利人:CUBIST PHARM INC
摘要:Provided herein is a method for the synthesis of cephalosporin antibiotic compounds comprising the conversion of a protected 7-amino group into a 7-carboxamide moiety in a single step.

专利号:US-4171438-A
优先权日:1975-07-23
标 题:0-2-Isocephem-4-carboxylic acid derivatives as antibacterial agents
发明人：DOUGLAS JAMES L; HORNING DONALD E; MORRIS LEESON R
权利人:BRISTOL MYERS CO
摘要:There is described the stereoselective total synthesis of novel DELTA 2,3-1,4-morpholine-2-carboxylic acids possessing a fused beta -lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula I wherein X is acylamino and Z represents optionally substituted C1-C6 alkyl, aryl or aralkyl. Also included in the invention are compounds of the above formula in which the carboxyl group at the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds. The compounds are potent antibacterial agents.

专利号:US-4118566-A
优先权日:1975-07-23
标 题:Δ2,3 -1,4-Morpholine-2-carboxylic acid derivatives as antibacterial agents
发明人：HORNING DONALD E; MORRIS LEESON R; DOUGLAS JAMES L
权利人:BRISTOL MYERS CO
摘要:There is described the stereoselective total synthesis of novel DELTA 2,3-1,4-morpholine-2-carboxylic acids possessing a fused beta -lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula I wherein X is amino, azido or acylamido and Z represents optionally substituted C1-C6 alkyl, aryl, aralkyl or heterocyclic. Also included in the invention are compounds of formula I in which the carboxyl group at the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds of formula I. The compounds of formula I are potent antibacterial agents or are of use as intermediates in the preparation of such antibacterial agents.

专利号:US-4950660-A
优先权日:1987-09-07
标 题:Beta-lactam compound and process for production thereof
发明人：ATSUMI KUNIO; YAMAMOTO YUICHI; SAKAGAMI KENJI; NISHIHATA KEN; KONDO SHINICHI
权利人:MEIJI SEIKA CO
摘要:The present invention relates to a cephem compound of formula (III) shown in the description. The compound is useful as an intermediate for the synthesis of beta -lactam antibiotics of new class and also to a process for producing the same. The cephem compound (III) is produced by reacting a cephem compound of formula (I) with a nitrogen-containing compound of formula (II) under acid-capturing conditions. The process can be performed easily under mild conditions.

专利号:US-4436912-A
优先权日:1981-09-08
标题:7-[2-(2-Aminooxazol-4-yl)-2-(oximino)acetamido cephalosporin antibiotics and intermediates therefor
发明人：WHEELER WILLIAM J
权利人:LILLY CO ELI
摘要:Cephalosporin broad spectrum antibiotics possessing a 7 beta -[2-[(2-aminooxazol)-4-yl]-2-(substituted oximino]acetamido side chain and a variety of substituents at the 3-position of the cephalosporins are claimed. Also claimed are intermediates in the synthesis of the above cephalosporin antibiotics.